PIP3 pathway in regulatory T cells and autoimmunity (Q28609463)

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Signaling inositol polyphosphate-5-phosphatase. Characterization of activity and effect of GRB2 association.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-007-0075-2

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

21 January 2018

1 reference

12 December 2020

The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling

1 reference

12 December 2020

Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway

1 reference

12 December 2020

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

1 reference

12 December 2020

The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood

1 reference

12 December 2020

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

1 reference

12 December 2020

The role of PI3K in immune cells

1 reference

12 December 2020

Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor.

1 reference

12 December 2020

Pten is essential for embryonic development and tumour suppression

1 reference

12 December 2020

SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity

1 reference

12 December 2020

SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain.

1 reference

12 December 2020

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

1 reference

12 December 2020

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

1 reference

12 December 2020

Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance

1 reference

12 December 2020

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells

1 reference

12 December 2020

Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou

1 reference

12 December 2020

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

1 reference

12 December 2020

Interleukin-7 (IL-7): immune function, involvement in the pathogenesis of HIV infection and therapeutic potential.

1 reference

12 December 2020

Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells

1 reference

12 December 2020

Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase

1 reference

12 December 2020

Induction of a regulatory T cell type 1 response reduces the development of atherosclerosis in apolipoprotein E-knockout mice

1 reference

12 December 2020

Journey through the thymus: stromal guides for T-cell development and selection

1 reference

12 December 2020

G3BP is overexpressed in human tumors and promotes S phase entry

1 reference

12 December 2020

Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F

1 reference

12 December 2020

Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase

1 reference

12 December 2020

Molecular and cellular pathogenesis of X-linked lymphoproliferative disease

1 reference

12 December 2020

B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein

1 reference

12 December 2020

Fueling regulation: IL-2 keeps CD4+ Treg cells fit

1 reference

12 December 2020

Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

1 reference

12 December 2020

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

1 reference

12 December 2020

The role of SHIP in cytokine-induced signaling

1 reference

12 December 2020

CD4+CD25+ regulatory T cells in health and disease.

1 reference

12 December 2020

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

1 reference

12 December 2020

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

1 reference

12 December 2020

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

1 reference

12 December 2020

Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

1 reference

12 December 2020

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

1 reference

12 December 2020

Signalling by PI3K isoforms: insights from gene-targeted mice.

1 reference

12 December 2020

Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors

1 reference

12 December 2020

Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway.

1 reference

12 December 2020

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif

1 reference

12 December 2020

Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor

1 reference

12 December 2020

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1 reference

12 December 2020

Rho family GTPases bind to phosphoinositide kinases

1 reference

12 December 2020

Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase

1 reference

12 December 2020

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

1 reference

12 December 2020

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

1 reference

12 December 2020

Restoration of SHIP-1 activity in human leukemic cells modifies NF-kappaB activation pathway and cellular survival upon oxidative stress

1 reference

12 December 2020

Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling

1 reference

12 December 2020

Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1.

1 reference

12 December 2020

Synthesis and function of 3-phosphorylated inositol lipids

1 reference

12 December 2020

Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP

1 reference

12 December 2020

Reversible inactivation of the tumor suppressor PTEN by H2O2

1 reference

12 December 2020

Compound heterozygosity for Pten and SHIP augments T-dependent humoral immune responses and cytokine production by CD(4+) T cells

1 reference

12 December 2020

Essential role of PDK1 in regulating cell size and development in mice

1 reference

12 December 2020

Phosphoinositide 3-kinase in T cell activation and survival.

1 reference

12 December 2020

Regulation of the immune response by SHIP.

1 reference

12 December 2020

Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor on human thymocytes

1 reference

12 December 2020

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

12 December 2020

The serine-rich cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and phosphatidylinositol-3-kinase activation.

1 reference

12 December 2020

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

12 December 2020

1 reference

12 December 2020

Negative feedback of T cell activation through inhibitory adapters and costimulatory receptors

1 reference

12 December 2020

PI3K in lymphocyte development, differentiation and activation

1 reference

12 December 2020

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

12 December 2020

The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells

1 reference

12 December 2020

Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1

1 reference

12 December 2020

Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors

1 reference

12 December 2020

An IL-2 receptor beta subdomain that controls Bcl-X(L) expression and cell survival

1 reference

12 December 2020

Altered responsiveness to chemokines due to targeted disruption of SHIP.

1 reference

12 December 2020

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

1 reference

12 December 2020

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1 reference

12 December 2020

Natural regulatory T cells control the development of atherosclerosis in mice

1 reference

12 December 2020

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

1 reference

12 December 2020

The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells

1 reference

12 December 2020

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling

1 reference

12 December 2020

The two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytes

1 reference

12 December 2020

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

1 reference

12 December 2020

Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma

1 reference

12 December 2020

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

1 reference

12 December 2020

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

1 reference

12 December 2020

The redox regulation of PI 3-kinase-dependent signaling

1 reference

12 December 2020

Regulation of the PTEN phosphatase

1 reference

12 December 2020

Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation

1 reference

12 December 2020

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

1 reference

12 December 2020

The SH2-containing inositol polyphosphate 5-phosphatase, ship, is expressed during hematopoiesis and spermatogenesis

1 reference

12 December 2020

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

1 reference

12 December 2020

Tec family kinases in T lymphocyte development and function

1 reference

12 December 2020

The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology

1 reference

12 December 2020

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

1 reference

12 December 2020

Suppressor T cells in human diseases

1 reference

12 December 2020

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1 reference

12 December 2020

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

1 reference

12 December 2020

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

1 reference

12 December 2020

Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

1 reference

12 December 2020

Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.

1 reference

12 December 2020

Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation

1 reference

12 December 2020

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency.

1 reference

12 December 2020

Anemia, thrombocytopenia, leukocytosis, extramedullary hematopoiesis, and impaired progenitor function in Pten+/-SHIP-/- mice: a novel model of myelodysplasia

1 reference

12 December 2020

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

12 December 2020

The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells

1 reference

12 December 2020

Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.

1 reference

12 December 2020

The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain

1 reference

12 December 2020

A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells

1 reference

12 December 2020

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

1 reference

12 December 2020

The role of erk1 and erk2 in multiple stages of T cell development.

1 reference

12 December 2020

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

1 reference

12 December 2020

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

1 reference

12 December 2020

An essential role for Scurfin in CD4+CD25+ T regulatory cells

1 reference

12 December 2020

Cutting edge: gab2 mediates an inhibitory phosphatidylinositol 3'-kinase pathway in T cell antigen receptor signaling

1 reference

12 December 2020

Regulatory T cells in immune surveillance and treatment of cancer.

1 reference

12 December 2020

Structure, function, and biology of SHIP proteins

1 reference

12 December 2020

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

1 reference

12 December 2020

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

12 December 2020

IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena

1 reference

12 December 2020

CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis

1 reference

12 December 2020

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

1 reference

12 December 2020

PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs

1 reference

12 December 2020

Distribution of the src-homology-2-domain-containing inositol 5-phosphatase SHIP-2 in both non-haemopoietic and haemopoietic cells and possible involvement of SHIP-2 in negative signalling of B-cells

1 reference

12 December 2020

The influence of the MAPK pathway on T cell lineage commitment

1 reference

12 December 2020

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

12 December 2020

Regulatory T cells: key controllers of immunologic self-tolerance

1 reference

12 December 2020

T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.

1 reference

12 December 2020

Modulation of specific protein expression levels by PTEN: identification of AKAP121, DHFR, G3BP, Rap1, and RCC1 as potential targets of PTEN.

1 reference

12 December 2020

FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization

1 reference

12 December 2020

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

12 December 2020

Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL)

1 reference

12 December 2020

Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL-)two to tango

1 reference

12 December 2020

SAP controls T cell responses to virus and terminal differentiation of TH2 cells.

1 reference

12 December 2020

Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development

1 reference

12 December 2020

SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase

1 reference

12 December 2020

The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway

1 reference

12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

1 reference

12 December 2020

Control of regulatory T cell development by the transcription factor Foxp3

1 reference

12 December 2020

The main function of IL-2 is to promote the development of T regulatory cells

1 reference

12 December 2020

Impaired Fas response and autoimmunity in Pten+/- mice

1 reference

12 December 2020

Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

1 reference

12 December 2020

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta

1 reference

12 December 2020

Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes.

1 reference

12 December 2020

The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation

1 reference

12 December 2020

T cell receptor stimulation, reactive oxygen species, and cell signaling

1 reference

12 December 2020

Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL.

1 reference

12 December 2020

The role of suppressor T cells in regulation of immune responses

1 reference

12 December 2020

Mechanisms of suppression by suppressor T cells

1 reference

12 December 2020

Normal T-cell development and immune functions in TRIM-deficient mice

1 reference

12 December 2020

Policing the regulators

1 reference

12 December 2020

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

1 reference

12 December 2020

T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2

1 reference

12 December 2020

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

1 reference

12 December 2020

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation

1 reference

12 December 2020

B cell antigen receptor stimulation induces formation of a Shc-Grb2 complex containing multiple tyrosine-phosphorylated proteins

1 reference

12 December 2020

Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo

1 reference

12 December 2020

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

12 December 2020

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

1 reference

12 December 2020

T cell receptor-associated alpha-phosphatidylinositol 3-kinase becomes activated by T cell receptor cross-linking and requires pp56lck

1 reference

12 December 2020

Phosphoinositide kinases

1 reference

12 December 2020

T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane

1 reference

12 December 2020

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

1 reference

12 December 2020

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

1 reference

12 December 2020

Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN

1 reference

12 December 2020

Loss of a single allele of SHIP exacerbates the immunopathology of Pten heterozygous mice

1 reference

12 December 2020

Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival

1 reference

12 December 2020

JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome

1 reference

12 December 2020

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

1 reference

12 December 2020

p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes

1 reference

12 December 2020

The B7-CD28 superfamily

1 reference

12 December 2020

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

1 reference

12 December 2020

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

1 reference

12 December 2020

Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle

1 reference

12 December 2020

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity

1 reference

12 December 2020

CD28 stimulates tyrosine phosphorylation, cellular redistribution and catalytic activity of the inositol lipid 5-phosphatase SHIP

1 reference

12 December 2020

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases

1 reference

12 December 2020

Phosphoinositide recognition domains

1 reference

12 December 2020

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

1 reference

12 December 2020

Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

1 reference

12 December 2020

Lipid phosphatases in the immune system

1 reference

12 December 2020

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

1 reference

12 December 2020

Regulatory T cells in the periphery

1 reference

12 December 2020

The phosphoinositide 3-kinase pathway

1 reference

12 December 2020

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

1 reference

12 December 2020

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

1 reference

12 December 2020

Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase

1 reference

12 December 2020

PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression

1 reference

12 December 2020

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

12 December 2020

Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

1 reference

12 December 2020

PI3K-signalling in B- and T-cells: insights from gene-targeted mice

1 reference

12 December 2020

Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment.

1 reference

12 December 2020

FOXP3: of mice and men.

1 reference

12 December 2020

Regulating the immune system: the induction of regulatory T cells in the periphery

1 reference

12 December 2020

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation

1 reference

12 December 2020

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

1 reference

12 December 2020

T lymphocytes on the move: chemokines, PI 3-kinase and beyond

1 reference

12 December 2020

Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules

1 reference

12 December 2020

Tolerance, not immunity, crucially depends on IL-2.

1 reference

12 December 2020

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

1 reference

12 December 2020

PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt.

1 reference

12 December 2020

PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models.

1 reference

12 December 2020

Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment

1 reference

12 December 2020

Regulation of immune responses by T cells

1 reference

12 December 2020

Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase

1 reference

12 December 2020