Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (Q37287417)

19 August 2017

1 reference

8 February 2021

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (English)

1 reference

lipid biosynthetic process

19 August 2017

1 reference

19 November 2019

1 reference

8 February 2021

1 reference

inferred from abstract

Barrie Peck

2

0 references

Almut Schulze

object named as

Almut Schulze

series ordinal

4

0 references

author name string

Franziska Baenke

series ordinal

1

1 reference

PMCID

3820259

19 August 2017

Heike Miess

series ordinal

3

1 reference

PMCID

3820259

19 August 2017

language of work or name

1 reference

1 November 2013

4 references

Disease Models & Mechanisms

19 August 2017

3 April 2019

19 November 2019

8 February 2021

4 references

19 August 2017

3 April 2019

19 November 2019

8 February 2021

6

1 reference

19 August 2017

6

1 reference

19 August 2017

1353-1363

1 reference

Creative Commons Attribution

19 August 2017

3 references

3 April 2019

19 November 2019

8 February 2021

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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6 September 2017

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6 September 2017

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Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

6 September 2017

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Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors

6 September 2017

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6 September 2017

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6 September 2017

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

6 September 2017

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6 September 2017

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Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells.

6 September 2017

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6 September 2017

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6 September 2017

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Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy

6 September 2017

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6 September 2017

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6 September 2017

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Revitalizing membrane rafts: new tools and insights

6 September 2017

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Dysregulation of the mevalonate pathway promotes transformation

6 September 2017

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

6 September 2017

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Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells

6 September 2017

1 reference

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Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

6 September 2017

1 reference

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Greasing their way: lipid modifications determine protein association with membrane rafts

6 September 2017

1 reference

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Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice

6 September 2017

1 reference

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Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes

6 September 2017

1 reference

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6 September 2017

Eicosanoids and cancer

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Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

6 September 2017

1 reference

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Androgen receptor survival signaling is blocked by anti-beta2-microglobulin monoclonal antibody via a MAPK/lipogenic pathway in human prostate cancer cells

6 September 2017

1 reference

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EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy

6 September 2017

1 reference

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Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK

6 September 2017

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Cell and molecular mechanisms of insulin-induced angiogenesis

6 September 2017

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Coordination of lipid metabolism in membrane biogenesis.

6 September 2017

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Hypoxia-inducible factor 2 regulates hepatic lipid metabolism

6 September 2017

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ATP-citrate lyase links cellular metabolism to histone acetylation

6 September 2017

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Autophagy regulates lipid metabolism

6 September 2017

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Microenvironmental regulation of metastasis

6 September 2017

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ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.

6 September 2017

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

6 September 2017

1 reference

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The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins

6 September 2017

1 reference

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

6 September 2017

1 reference

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Lipid signalling in disease.

6 September 2017

1 reference

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Principles of bioactive lipid signalling: lessons from sphingolipids

6 September 2017

1 reference

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Glucolipotoxicity: fuel excess and beta-cell dysfunction.

6 September 2017

1 reference

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

6 September 2017

1 reference

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

6 September 2017

1 reference

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SREBP in signal transduction: cholesterol metabolism and beyond

6 September 2017

1 reference

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The role of cholesterol in prostate cancer

6 September 2017

1 reference

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Increased lipogenesis in cancer cells: new players, novel targets.

6 September 2017

1 reference

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ATP citrate lyase inhibition can suppress tumor cell growth

6 September 2017

1 reference

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ATP citrate lyase is an important component of cell growth and transformation

6 September 2017

1 reference

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Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression

6 September 2017

1 reference

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The emerging role of lysophosphatidic acid in cancer

6 September 2017

1 reference

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Tumour-cell invasion and migration: diversity and escape mechanisms

6 September 2017

1 reference

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Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase

6 September 2017

1 reference

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Synthesis and function of 3-phosphorylated inositol lipids

6 September 2017

1 reference

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Synthesis and antitumor activity of an inhibitor of fatty acid synthase

6 September 2017

1 reference

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

6 September 2017

1 reference

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

6 September 2017

1 reference

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Fatty acid synthesis: a potential selective target for antineoplastic therapy

6 September 2017

1 reference

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Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression

6 September 2017

1 reference

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Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development.

14 September 2017

1 reference

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Hypoxia and the metabolic phenotype of prostate cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer–stromal cell interactions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Prostate cancer cell growth is modulated by adipocyte‐cancer cell interaction

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas

14 September 2017

1 reference

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Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.

26 June 2018

1 reference

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The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.

26 June 2018

1 reference

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Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities

26 June 2018

1 reference

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Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.

26 June 2018

1 reference

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Covalent lipid modifications of proteins

3 September 2018

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Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a.

3 September 2018

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De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Decrease in membrane phospholipid unsaturation induces unfolded protein response

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

In vitro, high-resolution 1H and 31P NMR based analysis of the lipid components in the tissue, serum, and CSF of the patients with primary brain tumors: one possible diagnostic view.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Hypoxia, HIF1 and glucose metabolism in the solid tumour

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Activation of sterol regulatory element-binding proteins (SREBPs) is critical in IL-8-induced angiogenesis.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820259

The lipogenesis pathway as a cancer target

3 September 2018

1 reference

12 December 2020

Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro

1 reference

12 December 2020

Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells

1 reference

12 December 2020

Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity

1 reference

12 December 2020

Phospholipase signalling networks in cancer

1 reference

12 December 2020

Identifiers

DOI

10.1242/DMM.011338

1 reference

19 August 2017

1 reference

19 August 2017

1 reference

PMCID

3820259