Oxidative stress and beta-cell dysfunction (Q37774895)

23 August 2017

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title

Oxidative stress and beta-cell dysfunction (English)

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23 August 2017

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Gisela Drews

1

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PubMed ID

20652307

23 August 2017

Peter Krippeit-Drews

series ordinal

2

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PubMed ID

20652307

23 August 2017

Martina Düfer

series ordinal

3

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23 August 2017

23 July 2010

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23 August 2017

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23 August 2017

460

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23 August 2017

4

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23 August 2017

703-718

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https://scigraph.springernature.com/pub.10.1007/s00424-010-0862-9

23 August 2017

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cites work

Role of nitric oxide synthase isoforms in glucose-stimulated insulin release

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

Free radicals in the physiological control of cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

Dual effect of nitric oxide on cytosolic Ca2+ concentration and insulin secretion in rat pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

The mitochondrial permeability transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

Phosphocreatine as a determinant of K(ATP) channel activity in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

Thiol oxidation by 2,2'-dithiodipyridine causes a reversible increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells. Role for inositol 1,4,5-trisphosphate-sensitive Ca2+ stores.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

Suppressive effects of glucagon-like peptide-1 on interferon-gamma-induced nitric oxide production in insulin-producing cells is mediated by inhibition of tumor necrosis factor-alpha production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

The KATP channel is critical for calcium sequestration into non-ER compartments in mouse pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

Effects of antioxidants coenzyme Q10 and lipoic acid on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-010-0862-9

Streptozocin- and Alloxan-Induced H2O2 Generation and DNA Fragmentation in Pancreatic Islets: H2O2 as Mediator for DNA Fragmentation

21 January 2018

1 reference

12 December 2020

beta cell cytoprotective strategies: establishing the relative roles for iNOS and ROS.

1 reference

12 December 2020

Effects of nitric oxide synthase inhibitors and melatonin on the hyperglycemic response to streptozotocin in rats.

1 reference

12 December 2020

The NEPI antidiabetes study (NANSY). 1: short-term dose-effect relations of glimepiride in subjects with impaired fasting glucose

1 reference

12 December 2020

Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function

1 reference

12 December 2020

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

1 reference

12 December 2020

Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

1 reference

12 December 2020

Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases.

1 reference

12 December 2020

Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice.

1 reference

12 December 2020

The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology

1 reference

12 December 2020

Reactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells

1 reference

12 December 2020

MnTMPyP, a metalloporphyrin-based superoxide dismutase/catalase mimetic, protects INS-1 cells and human pancreatic islets from an in vitro oxidative challenge

1 reference

12 December 2020

Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function

1 reference

12 December 2020

Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes

1 reference

12 December 2020

Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus

1 reference

12 December 2020

Thioredoxin-interacting protein is killing my beta-cells!

1 reference

12 December 2020

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

1 reference

12 December 2020

Depletion of intracellular Ca2+ stores activates a maitotoxin-sensitive nonselective cationic current in beta-cells.

1 reference

12 December 2020

Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.

1 reference

12 December 2020

Reciprocal amplification of ROS and Ca(2+) signals in stressed mdx dystrophic skeletal muscle fibers.

1 reference

12 December 2020

Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes

1 reference

12 December 2020

Dual effect of nitric oxide on ATP-sensitive K+ channels in rat pancreatic beta cells

1 reference

12 December 2020

Exogenous nitric oxide (NO) generation or IL-1 beta-induced intracellular NO production stimulates inhibitory auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase in RINm5F cells.

1 reference

12 December 2020

Pancreatic islet beta-cell and oxidative stress: the importance of glutathione peroxidase

1 reference

12 December 2020

Hydrogen peroxide induces intracellular calcium overload by activation of a non-selective cation channel in an insulin-secreting cell line

1 reference

12 December 2020

Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets

1 reference

12 December 2020

Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress

1 reference

12 December 2020

Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death

1 reference

12 December 2020

Endocrinology: nitric oxide-mediated insulin secretion in response to citrulline in islet beta-cells

1 reference

12 December 2020

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

1 reference

12 December 2020

The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes

1 reference

12 December 2020

Low doses of hydrogen peroxide impair glucose-stimulated insulin secretion via inhibition of glucose metabolism and intracellular calcium oscillations

1 reference

12 December 2020

H2O2 induced hyperpolarization of pancreatic B-cells

1 reference

12 December 2020

The use of nitric oxide donors in pharmacological studies.

1 reference

12 December 2020

Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic beta-cell line, MIN6.

1 reference

12 December 2020

Prevention of diabetes and cardiovascular disease in patients with impaired glucose tolerance: rationale and design of the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial

1 reference

12 December 2020

In vitro and in vivo antioxidant properties of gliclazide.

1 reference

12 December 2020

Diverse effects of hydrogen peroxide on cytosolic Ca2+ homeostasis in rat pancreatic beta-cells

1 reference

12 December 2020

Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms

1 reference

12 December 2020

Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose

1 reference

12 December 2020

Protection against streptozotocin-induced diabetes by superoxide dismutase

1 reference

12 December 2020

Drugs producing diabetes through damage of the insulin secreting cells

1 reference

12 December 2020

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

1 reference

12 December 2020

Mechanisms of pancreatic beta-cell destruction in type I diabetes

1 reference

12 December 2020

Contrasting effects of alloxan on islets and single mouse pancreatic beta-cells

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12 December 2020

Study of gene regulation by NF-kappa B and AP-1 in response to reactive oxygen intermediates

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12 December 2020

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

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12 December 2020

Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides

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12 December 2020

Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.

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12 December 2020

Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury

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12 December 2020

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection

1 reference

12 December 2020

Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells. Studies in aequorin-expressing intact and permeabilized ins-1 cells

1 reference

12 December 2020

Sulfonylurea induced beta-cell apoptosis in cultured human islets

1 reference

12 December 2020

Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells

1 reference

12 December 2020

Destruction of rat pancreatic islet beta-cells by cytokines involves the production of cytotoxic aldehydes.

1 reference

12 December 2020

The effects of nitric oxide on the membrane potential and ionic currents of mouse pancreatic B cells

1 reference

12 December 2020

TRPM2 functions as a lysosomal Ca2+-release channel in beta cells

1 reference

12 December 2020

TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion

1 reference

12 December 2020

Mitochondria mediated cell death in diabetes

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12 December 2020

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

1 reference

12 December 2020

Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes

1 reference

12 December 2020

The effect of repaglinide on insulin secretion and oxidative stress in type 2 diabetic patients

1 reference

12 December 2020

Glutaredoxin-1 mediates NADPH-dependent stimulation of calcium-dependent insulin secretion

1 reference

12 December 2020

Metallothionein and catalase sensitize to diabetes in nonobese diabetic mice: reactive oxygen species may have a protective role in pancreatic beta-cells

1 reference

12 December 2020

Involvement of ATP-sensitive K+ channels in free radical-mediated inhibition of insulin secretion in rat pancreatic beta-cells

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12 December 2020

Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein

1 reference

12 December 2020

Protective role of superoxide dismutase against diabetogenic drugs

1 reference

12 December 2020

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

1 reference

12 December 2020

Role of mitochondria in metabolism-secretion coupling of insulin release in the pancreatic beta-cell

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12 December 2020

Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets

1 reference

12 December 2020

Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.

1 reference

12 December 2020

Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production

1 reference

12 December 2020

Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines.

1 reference

12 December 2020

Coordinated behavior of mitochondria in both space and time: a reactive oxygen species-activated wave of mitochondrial depolarization

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12 December 2020

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

1 reference

12 December 2020

Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.

1 reference

12 December 2020

Glucose-induced oscillations in cytoplasmic free Ca2+ concentration precede oscillations in mitochondrial membrane potential in the pancreatic beta-cell.

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12 December 2020

A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

1 reference

12 December 2020

Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus

1 reference

12 December 2020

Electrophysiology of islet cells

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12 December 2020

Dependence on NADH produced during glycolysis for beta-cell glucose signaling

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12 December 2020

Dual effect of NO on K(+)(ATP) current of mouse pancreatic B-cells: stimulation by deenergizing mitochondria and inhibition by direct interaction with the channel

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12 December 2020

Effect of the sulphonylurea glibenclamide on liver and kidney antioxidant enzymes in streptozocin-induced diabetic rats

1 reference

12 December 2020

Metabolic evolution suggests an explanation for the weakness of antioxidant defences in beta-cells

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12 December 2020

Role of nitric oxide in obesity-induced beta cell disease

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12 December 2020

Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action

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12 December 2020

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

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12 December 2020

Mitochondrial networking protects beta-cells from nutrient-induced apoptosis.

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12 December 2020

Subcellular localization of Nox4 and regulation in diabetes

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12 December 2020

Beta-cell defence and repair mechanisms in human pancreatic islets

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12 December 2020

Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice

1 reference

12 December 2020

Spin trapping agent phenyl N-tert-butylnitrone protects against the onset of drug-induced insulin-dependent diabetes mellitus

1 reference

12 December 2020

Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes

1 reference

12 December 2020

An adenylate kinase is involved in KATP channel regulation of mouse pancreatic beta cells

1 reference

12 December 2020

Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes

1 reference

12 December 2020

Expression of isoforms of NADPH oxidase components in rat pancreatic islets

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12 December 2020

Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells.

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12 December 2020

Effects of oxidants on membrane potential, K+ and Ca2+ currents of mouse pancreatic B-cells

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12 December 2020

Sulfhydryl oxidation induces rapid and reversible closure of the ATP-regulated K+ channel in the pancreatic beta-cell

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12 December 2020

Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax.

1 reference

12 December 2020

Antioxidants, NFkappaB activation, and diabetogenesis

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12 December 2020

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

1 reference

12 December 2020

L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis

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12 December 2020

Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells

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12 December 2020

Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

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12 December 2020

The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress.

1 reference

12 December 2020

Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]m

1 reference

12 December 2020

Serum 8-hydroxy-guanine levels are increased in diabetic patients

1 reference

12 December 2020

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

1 reference

12 December 2020

Cell signaling. H2O2, a necessary evil for cell signaling

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12 December 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

12 December 2020

The role of inflammation in insulitis and beta-cell loss in type 1 diabetes

1 reference

12 December 2020

TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells

1 reference

12 December 2020

Alloxan-induced alteration of insulin release, rubidium efflux and glucose metabolism in rat islets stimulated by various secretagogues

1 reference

12 December 2020

Suppressive effects of a selective inducible nitric oxide synthase (iNOS) inhibitor on pancreatic beta-cell dysfunction

1 reference

12 December 2020

Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion

1 reference

12 December 2020

Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity

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12 December 2020

Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells

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12 December 2020

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12 December 2020

Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet beta-cells.

1 reference

12 December 2020

Free radical scavenging activity of sulfonylureas: a clinical assessment of the effect of gliclazide

1 reference

12 December 2020

Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: a systematic review

1 reference

12 December 2020

Evaluation of oxidative stress before and after control of glycemia and after vitamin E supplementation in diabetic patients

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12 December 2020

Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals.

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12 December 2020

Reactive oxygen species as a signal in glucose-stimulated insulin secretion

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12 December 2020

Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line

1 reference

12 December 2020

Elevated levels of authentic plasma hydroperoxides in NIDDM.

1 reference

12 December 2020

Effects of SH-group reagents on Ca2+ and K+ channel currents of pancreatic B-cells

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12 December 2020

MnSOD mimic compounds can counteract mechanical stress and islet beta cell apoptosis, although at appropriate concentration ranges

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12 December 2020

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

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12 December 2020

Mitochondrial formation of reactive oxygen species

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12 December 2020

Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species

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12 December 2020

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

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12 December 2020

Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells.

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12 December 2020

Increased number of islet-associated macrophages in type 2 diabetes.

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12 December 2020

Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice

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12 December 2020

Beta cell cytoprotection using lentiviral vector-based iNOS-specific shRNA delivery.

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12 December 2020

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet

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12 December 2020

Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-Cells

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12 December 2020

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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12 December 2020

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

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12 December 2020

Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses.

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12 December 2020

Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification

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12 December 2020

Functional and molecular defects of pancreatic islets in human type 2 diabetes

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12 December 2020

Long-term effects of aminoguanidine on insulin release and biosynthesis: evidence that the formation of advanced glycosylation end products inhibits B cell function

1 reference

12 December 2020

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

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12 December 2020

The non-peptidyl low molecular weight radical scavenger IAC protects human pancreatic islets from lipotoxicity.

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12 December 2020

Emptying of intracellular Ca2+ stores stimulates Ca2+ entry in mouse pancreatic beta-cells by both direct and indirect mechanisms

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12 December 2020

Role of increased ROS dissipation in prevention of T1D.

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12 December 2020

The effects of sulfonylurea glyburide on superoxide dismutase, catalase, and glutathione peroxidase activities in the brain tissue of streptozotocin-induced diabetic rat.

1 reference

12 December 2020

Mitochondrial ROS-induced ROS release: an update and review

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12 December 2020

Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL.

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12 December 2020

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity

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12 December 2020

Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus

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12 December 2020

Crosstalk signaling between mitochondrial Ca2+ and ROS.

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12 December 2020

Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells

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12 December 2020

Contribution of adenoviral-mediated superoxide dismutase gene transfer to the reduction in nitric oxide-induced cytotoxicity on human islets and INS-1 insulin-secreting cells

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12 December 2020

The mitochondrial death pathway: a promising therapeutic target in diseases

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12 December 2020

Visualizing superoxide production in normal and diabetic rat islets of Langerhans

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12 December 2020

Ca(2+) rise within a narrow window of concentration prevents functional injury of mitochondria exposed to hypoxia/reoxygenation by increasing antioxidative defence

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12 December 2020

Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit

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12 December 2020

Dual effect of glucose on cytoplasmic Ca2+ in single pancreatic beta-cells

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12 December 2020

Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells

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12 December 2020

Functions and dysfunctions of mitochondrial dynamics

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12 December 2020

Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

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12 December 2020

Protection of insulin-secreting INS-1 cells against oxidative stress through adenoviral-mediated glutathione peroxidase overexpression

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12 December 2020

Interference of H2O2 with stimulus-secretion coupling in mouse pancreatic beta-cells

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12 December 2020

Cyclic variations of glucose-induced electrical activity in pancreatic B cells

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12 December 2020

Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis

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12 December 2020

Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic beta-cells against oxidative stress

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12 December 2020

Partial protection against streptozotocin-induced hyperglycaemia by superoxide dismutase linked to polyethylene glycol

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12 December 2020

beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice

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12 December 2020

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

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12 December 2020

Nitric oxide opens ATP-sensitive K+ channels through suppression of phosphofructokinase activity and inhibits glucose-induced insulin release in pancreatic beta cells

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12 December 2020

Nitric oxide (nitrogen monoxide, NO) stimulates insulin secretion by inducing calcium release from mitochondria

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12 December 2020

Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1.

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12 December 2020

Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist

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12 December 2020

Telmisartan attenuates fatty-acid-induced oxidative stress and NAD(P)H oxidase activity in pancreatic beta-cells

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12 December 2020

Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells

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12 December 2020

Feedback control of the ATP-sensitive K(+) current by cytosolic Ca(2+) contributes to oscillations of the membrane potential in pancreatic beta-cells

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12 December 2020

The mitochondrion in apoptosis: how Pandora's box opens

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12 December 2020

Angiotensin II Type 1 Receptor Antagonism Mediates Uncoupling Protein 2-Driven Oxidative Stress and Ameliorates Pancreatic Islet β-Cell Function in Young Type 2 Diabetic Mice

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12 December 2020

Constitutive nitric oxide synthases in rat pancreatic islets: direct imaging of glucose-induced nitric oxide production in beta-cells

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12 December 2020

Protective mechanism of glucose against alloxan-induced pancreatic beta-cell damage.

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12 December 2020

Mitochondrial matrix phosphoproteome: effect of extra mitochondrial calcium

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12 December 2020

The effects of the sulfonylurea glyburide on glutathione peroxidase, superoxide dismutase and catalase activities in the heart tissue of streptozotocin-induced diabetic rat.

1 reference

12 December 2020

Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell

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12 December 2020

Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?

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12 December 2020

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

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12 December 2020

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

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12 December 2020

Glutathione peroxidase protein expression and activity in human islets isolated for transplantation

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12 December 2020

10.1007/S00424-010-0862-9

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

20652307