New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms (Q37921910)

25 August 2017

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title

New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms (English)

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25 August 2017

0 references

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4

Hans-Ulrich Häring

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25 August 2017

3

Andreas Fritsche

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25 August 2017

2

Fausto Machicao

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25 August 2017

Konstantinos Kantartzis

series ordinal

5

object named as

Konstantinos Kantartzis

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25 August 2017

Silke A Herzberg-Schäfer

series ordinal

1

object named as

Silke A Schäfer

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25 August 2017

publication date

1 August 2011

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Diabetes Research and Clinical Practice

25 August 2017

published in

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25 August 2017

volume

93 Suppl 1

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25 August 2017

page(s)

S9-24

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Global and societal implications of the diabetes epidemic

25 August 2017

cites work

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The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

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Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study

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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

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Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses

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7 January 2021

Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: Studies in 6018 whites

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7 January 2021

The K121Q Polymorphism of the ENPP1/PC-1 Gene Is Associated With Insulin Resistance/Atherogenic Phenotypes, Including Earlier Onset of Type 2 Diabetes and Myocardial Infarction

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7 January 2021

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects

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Effect of ENPP1/PC-1-K121Q and PPARgamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population

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7 January 2021

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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7 January 2021

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

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Clinical risk factors, DNA variants, and the development of type 2 diabetes

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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

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7 January 2021

Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

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7 January 2021

Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity

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7 January 2021

Common Adiponectin Gene Variants Show Different Effects on Risk of Cardiovascular Disease and Type 2 Diabetes in European Subjects

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7 January 2021

Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy

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7 January 2021

Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes.

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Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects

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7 January 2021

Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes

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7 January 2021

Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial

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7 January 2021

Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes

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AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects

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7 January 2021

A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians

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7 January 2021

Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes

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7 January 2021

A SNP haplotype of the forkhead transcription factor FOXO1A gene may have a protective effect against type 2 diabetes in German Caucasians.

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7 January 2021

Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies

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7 January 2021

Association of SGK 1 Gene polymorphisms with type 2 diabetes

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7 January 2021

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

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7 January 2021

Sex hormone-binding globulin and risk of type 2 diabetes in women and men

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7 January 2021

Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns

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7 January 2021

Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

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7 January 2021

Common variants in WFS1 confer risk of type 2 diabetes

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7 January 2021

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

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7 January 2021

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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7 January 2021

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

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7 January 2021

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

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7 January 2021

Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent

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7 January 2021

Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening

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7 January 2021

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

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7 January 2021

Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.

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7 January 2021

Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians

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7 January 2021

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies

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7 January 2021

Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.

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7 January 2021

Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.

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7 January 2021

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

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7 January 2021

Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals

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7 January 2021

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study

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7 January 2021

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

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7 January 2021

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

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7 January 2021

Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion

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7 January 2021

A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion

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7 January 2021

Variants in MTNR1B influence fasting glucose levels

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7 January 2021

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

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7 January 2021

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

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7 January 2021

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

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7 January 2021

Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response

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7 January 2021

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function

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Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians

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7 January 2021

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals

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7 January 2021

Genome-wide association studies provide new insights into type 2 diabetes aetiology

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7 January 2021

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

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7 January 2021

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk

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7 January 2021

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels

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7 January 2021

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

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7 January 2021

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

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7 January 2021

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

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7 January 2021

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

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7 January 2021

Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?

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7 January 2021

Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals.

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7 January 2021

The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects

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7 January 2021

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

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7 January 2021

Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes

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7 January 2021

The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population

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7 January 2021

Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance.

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7 January 2021

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia

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7 January 2021

ENPP1 gene, insulin resistance and related clinical outcomes

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7 January 2021

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study

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7 January 2021

The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention

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7 January 2021

Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes

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7 January 2021

The glucose clamp reveals an association between adiponectin gene polymorphisms and insulin sensitivity in obese subjects

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7 January 2021

The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects

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7 January 2021

Genetic Variations inPPARDandPPARGC1ADetermine Mitochondrial Function and Change in Aerobic Physical Fitness and Insulin Sensitivity during Lifestyle Intervention

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7 January 2021

alpha2-Heremans-Schmid glycoprotein gene polymorphisms are associated with adipocyte insulin action

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7 January 2021

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

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7 January 2021

Targeted suppression of calpain-10 expression impairs insulin-stimulated glucose uptake in cultured primary human skeletal muscle cells

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7 January 2021

Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes

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7 January 2021

Coordinated control of both insulin secretion and insulin action through calpain-10-mediated regulation of exocytosis?

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7 January 2021

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function

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7 January 2021

Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D

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7 January 2021

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

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7 January 2021

Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes

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7 January 2021

Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH.

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7 January 2021

Increased insulin clearance in peroxisome proliferator-activated receptor gamma2 Pro12Ala

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7 January 2021

Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit

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7 January 2021

Multigenic control of serum adiponectin levels: evidence for a role of the APM1 gene and a locus on 14q13.

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7 January 2021

The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Interactions Between Noncontiguous Haplotypes in the Adiponectin Gene ACDC Are Associated With Plasma Adiponectin

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Adipose tissue-derived factors: impact on health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Adiponectin and adiponectin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

The Relationships of Plasma Adiponectin with a Favorable Lipid Profile, Decreased Inflammation, and Less Ectopic Fat Accumulation Depend on Adiposity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Adiponectin oligomers and ectopic fat in liver and skeletal muscle in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Causes and metabolic consequences of Fatty liver

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Role of mitochondrial dysfunction in insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Mitochondrial dysfunction in type 2 diabetes and obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

AHSG gene variation is not associated with regional body fat distribution--a magnetic resonance study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Plasma fetuin-A levels and the risk of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Fetuin-A and incident diabetes mellitus in older persons

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Association of AHSG Gene Polymorphisms With Fetuin-A Plasma Levels and Cardiovascular Diseases in the EPIC-Potsdam Study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Variation in FTO contributes to childhood obesity and severe adult obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Variation in the FTO gene influences food intake but not energy expenditure

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Obesity associated genetic variation in FTO is associated with diminished satiety

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

An obesity-associated FTO gene variant and increased energy intake in children

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Common variants near MC4R are associated with fat mass, weight and risk of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Glucose-stimulated signaling pathways in biphasic insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Regulation of insulin secretion: a matter of phase control and amplitude modulation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Cellular and molecular biology of the beta cell

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

The importance of the beta-cell in the pathogenesis of type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Type 2 diabetes, insulin secretion and beta-cell mass

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Mechanisms linking obesity to insulin resistance and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Insulin granule biogenesis, trafficking and exocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

K(ATP) channelopathies in the pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Mechanisms of action of glucagon-like peptide 1 in the pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

The contribution of incretin hormones to the pathogenesis of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Functional significance of the UCSNP-43 polymorphism in the CAPN10 gene for proinsulin processing and insulin secretion in nondiabetic Germans

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Calpain facilitates actin reorganization during glucose-stimulated insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Selective versus total insulin resistance: a pathogenic paradox

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Diabetes: outfoxing insulin resistance?

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Targeting SGK1 in diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates glucocorticoid-induced inhibition of insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Characterisation of beta-cell dysfunction of impaired glucose tolerance: evidence for impairment of incretin-induced insulin secretion.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Melatonin inhibits insulin secretion and decreases PKA levels without interfering with glucose metabolism in rat pancreatic islets.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Parallel signaling pathways of melatonin in the pancreatic beta-cell

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Function and expression of melatonin receptors on human pancreatic islets

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Wnt signaling regulates pancreatic beta cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Wolfram (DIDMOAD) syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Molecular biology and the prolonged QT syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

KCNQ1-dependent transport in renal and gastrointestinal epithelia

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Whole-grain consumption and transcription factor-7-like 2 ( TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Predictive genetic testing for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

The importance of TCF7L2.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Revisiting the clinical validity of multiplex genetic testing in complex diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene–gene interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

How many genes underlie the occurrence of common complex diseases in the population?

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8227%2811%2970008-0

7 January 2021

10.1016/S0168-8227(11)70008-0

Identifiers

DOI

1 reference

25 August 2017

1 reference