Deubiquitinases in cancer: new functions and therapeutic options. (Q37945451)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Deubiquitinases in cancer: new functions and therapeutic options (English)

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14 February 2020

2

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14 February 2020

Carlos López Otín

5

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14 February 2020

David Rodríguez

3

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14 February 2020

Jose M Freije

4

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14 February 2020

author name string

J M Fraile

1

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14 February 2020

language of work or name

English

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publication date

26 September 2011

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14 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

volume

31

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14 February 2020

issue

19

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14 February 2020

page(s)

2373-2388

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https://scigraph.springernature.com/pub.10.1038/onc.2011.443

14 February 2020

exact match

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FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

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31 March 2020

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USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation.

31 March 2020

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Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome

31 March 2020

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Deubiquitinating enzymes are IN/(trinsic to proteasome function).

31 March 2020

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Frequent mutation of BAP1 in metastasizing uveal melanomas

31 March 2020

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Deubiquitinases in the regulation of NF-κB signaling

31 March 2020

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The p53 pathway: positive and negative feedback loops

31 March 2020

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Integrating genetic approaches into the discovery of anticancer drugs

31 March 2020

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Reduced expression of CYLD in human colon and hepatocellular carcinomas

31 March 2020

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Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening

31 March 2020

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TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

31 March 2020

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Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

31 March 2020

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Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

31 March 2020

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The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2011.443

The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling

31 March 2020

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DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

31 March 2020

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A20: from ubiquitin editing to tumour suppression

31 March 2020

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Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling

31 March 2020

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UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction

31 March 2020

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Analysis of cis-acting sequences and trans-acting factors regulating the interleukin-3 response element of the DUB-1 gene

31 March 2020

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Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

31 March 2020

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BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

31 March 2020

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Regulation of cell cycle progression and gene expression by H2A deubiquitination

31 March 2020

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The concept of synthetic lethality in the context of anticancer therapy

31 March 2020

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Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis.

31 March 2020

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PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications

31 March 2020

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Deubiquitinating enzyme USP36 contains the PEST motif and is polyubiquitinated

31 March 2020

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Wnt signalling and its impact on development and cancer

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Breaking the chains: structure and function of the deubiquitinases

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The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

31 March 2020

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Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

31 March 2020

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Inactivation of HAUSP in vivo modulates p53 function

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Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

31 March 2020

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The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2011.443

GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma

31 March 2020

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Enhancement of proteasome activity by a small-molecule inhibitor of USP14

31 March 2020

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HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated, polyneddylated, and dimerized

31 March 2020

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The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation

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Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein

31 March 2020

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VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha

31 March 2020

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Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor

31 March 2020

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MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling

31 March 2020

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Regulation of ErbB2 receptor status by the proteasomal DUB POH1.

31 March 2020

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JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress

31 March 2020

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Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2011.443

Proteases: multifunctional enzymes in life and disease

31 March 2020

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The regulatory crosstalk between kinases and proteases in cancer

31 March 2020

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Protease degradomics: a new challenge for proteomics

31 March 2020

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Mechanisms, biology and inhibitors of deubiquitinating enzymes

31 March 2020

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USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1

31 March 2020

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Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells

31 March 2020

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The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling

31 March 2020

1 reference

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An atlas of altered expression of deubiquitinating enzymes in human cancer

31 March 2020

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Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain

31 March 2020

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Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain

31 March 2020

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Proteolytic networks in cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2011.443

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2011.443

Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ataxin-3 is subject to autolytic cleavage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

AMSH is an endosome-associated ubiquitin isopeptidase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

An RNAi screen identifies USP2 as a factor required for TNF-α-induced NF-κB signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Derailed endocytosis: an emerging feature of cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Pharmacophore model for novel inhibitors of ubiquitin isopeptidases that induce p53-independent cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The USP1/UAF1 complex promotes double-strand break repair through homologous recombination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The 26 S proteasome: from basic mechanisms to drug targeting

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The ubiquitin-specific protease USP28 is required for MYC stability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

NF-kappaB and cancer: how intimate is this relationship

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The isopeptidase USP2a protects human prostate cancer from apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A genomic analysis of rat proteases and protease inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Human and mouse proteases: a comparative genomic approach

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The Degradome database: mammalian proteases and diseases of proteolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Dysregulated TRK signalling is a therapeutic target in CYLD defective tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The role of deubiquitinating enzymes in apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Synthetic lethal approaches to breast cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Negative regulation of JNK signaling by the tumor suppressor CYLD.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

CYLD mutations in familial skin appendage tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Suppression of cancer cell growth by promoting cyclin D1 degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Non-oncogene addiction and the stress phenotype of cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Defining the human deubiquitinating enzyme interaction landscape

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The tumor suppressor CYLD regulates entry into mitosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Targeting proteases: successes, failures and future prospects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Protein partners of deubiquitinating enzymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Cancer genes and the pathways they control

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Regulation of ubiquitin-dependent processes by deubiquitinating enzymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

CSN5/Jab1 controls multiple events in the mammalian cell cycle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP10 regulates p53 localization and stability by deubiquitinating p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Synergistic antitumor activity of gemcitabine and ABT-737 in vitro and in vivo through disrupting the interaction of USP9X and Mcl-1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Transcriptional regulation by histone ubiquitination and deubiquitination.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

High incidence of ubiquitin-like domains in human ubiquitin-specific proteases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.443

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference