X-linked inhibitor of apoptosis protein - a critical death resistance regulator and therapeutic target for personalized cancer therapy. (Q38239689)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120954%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

X-linked inhibitor of apoptosis protein - a critical death resistance regulator and therapeutic target for personalized cancer therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120954%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

Michael J Ausserlechner

series ordinal

2

1 reference

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12 March 2020

author name string

Petra Obexer

series ordinal

1

1 reference

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12 March 2020

publication date

28 July 2014

1 reference

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12 March 2020

published in

Frontiers in Oncology

1 reference

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12 March 2020

volume

4

1 reference

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12 March 2020

page(s)

197

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Many players in BCL-2 family affairs

12 March 2020

cites work

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The structure of XIAP BIR2: understanding the selectivity of the BIR domains

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IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation

6 September 2017

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Linear ubiquitination prevents inflammation and regulates immune signalling

6 September 2017

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XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38− cells in a phase 1/2 study of patients with relapsed/refractory AML

6 September 2017

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IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

6 September 2017

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Asymmetric recruitment of cIAPs by TRAF2

6 September 2017

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Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

6 September 2017

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X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists

6 September 2017

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Ubiquitin-binding domains - from structures to functions

6 September 2017

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Overexpression of X-linked inhibitor of apoptosis protein (XIAP) is an independent unfavorable prognostic factor in childhood de novo acute myeloid leukemia

6 September 2017

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XIAP discriminates between type I and type II FAS-induced apoptosis

6 September 2017

1 reference

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Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists

6 September 2017

1 reference

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SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

6 September 2017

1 reference

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Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) †

6 September 2017

1 reference

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Regulation of apoptosis by XIAP ubiquitin-ligase activity

6 September 2017

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Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence

6 September 2017

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c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

6 September 2017

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

6 September 2017

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

6 September 2017

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

6 September 2017

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Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

6 September 2017

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XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization

6 September 2017

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Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP

6 September 2017

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Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites

6 September 2017

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

6 September 2017

1 reference

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TAK1-binding protein 1 is a pseudophosphatase.

6 September 2017

1 reference

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

6 September 2017

1 reference

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PIDD mediates NF-kappaB activation in response to DNA damage

6 September 2017

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Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases

6 September 2017

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Expression of the inhibitors of apoptosis proteins in cisplatin-resistant prostate cancer cells.

6 September 2017

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Disturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomas

6 September 2017

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Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

6 September 2017

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Cisplatin Resistance in an Ovarian Carcinoma Is Associated With a Defect in Programmed Cell Death Control Through XIAP Regulation

6 September 2017

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The role of the Bcl-2 protein family in cancer

6 September 2017

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Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer

6 September 2017

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Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

6 September 2017

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Characterization of XIAP-deficient mice

6 September 2017

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

6 September 2017

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Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias

6 September 2017

1 reference

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The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

6 September 2017

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Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis.

6 September 2017

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Two CD95 (APO-1/Fas) signaling pathways

6 September 2017

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

6 September 2017

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Smac mimetic LBW242 sensitizes XIAP-overexpressing neuroblastoma cells for TNF-α-independent apoptosis

6 September 2017

1 reference

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Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.

6 September 2017

1 reference

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c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

6 September 2017

1 reference

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Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis

14 September 2017

1 reference

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IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

14 September 2017

1 reference

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XIAP is highly expressed in esophageal cancer and its downregulation by RNAi sensitizes esophageal carcinoma cell lines to chemotherapeutics

14 September 2017

1 reference

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Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin and Hodgkin lymphomas

14 September 2017

1 reference

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14 September 2017

1 reference

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Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

Tissue microarray analysis of X-linked inhibitor of apoptosis (XIAP) expression in breast cancer patients

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

XIAP expression is post-transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing

31 August 2018

1 reference

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Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

XIAP expression is an independent prognostic marker in clear-cell renal carcinomas.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112792

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.3389%2FFONC.2014.00197

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.3389%2FFONC.2014.00197

Clinical and prognostic importance of XIAP and USP8 in advanced stages of non-small cell lung cancer

21 January 2018

1 reference

12 December 2020

Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

1 reference

12 December 2020

XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis

1 reference

12 December 2020

Overexpression of XIAP expression in renal cell carcinoma predicts a worse prognosis

1 reference

12 December 2020

Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

1 reference

12 December 2020

Identifiers

DOI

10.3389/FONC.2014.00197

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120954%20AND%20SRC:MED&resulttype=core&format=json

release_fyivfusxa5gq5oou4vomdlocw4

12 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fyivfusxa5gq5oou4vomdlocw4

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120954%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

25120954

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25120954%20AND%20SRC:MED&resulttype=core&format=json