Revisiting STAT3 signalling in cancer: new and unexpected biological functions (Q38262473)

1 September 2017

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title

Revisiting STAT3 signalling in cancer: new and unexpected biological functions (English)

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1 September 2017

Hua Yu

1

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1 September 2017

Heehyoung Lee

2

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1 September 2017

Andreas Herrmann

3

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1 September 2017

Ralf Buettner

4

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1 September 2017

Richard Jove

5

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1 September 2017

language of work or name

English

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publication date

1 November 2014

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1 September 2017

Nature Reviews Cancer

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1 September 2017

14

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1 September 2017

736-746

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1 September 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrc3818

1 September 2017

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Let-7 expression is a significant determinant of response to chemotherapy through the regulation of IL-6/STAT3 pathway in esophageal squamous cell carcinoma

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Inflammation and cancer: IL-6 and STAT3 complete the link.

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STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

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IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development

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31 March 2020

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Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells

31 March 2020

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S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.

31 March 2020

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31 March 2020

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Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

31 March 2020

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The outs and the ins of sphingosine-1-phosphate in immunity

31 March 2020

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Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients

31 March 2020

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Effect of a novel anatomically shaped endotracheal tube on intubation-related injury

31 March 2020

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Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells.

31 March 2020

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Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

1 reference

MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin-6-Stat3 pathway

31 March 2020

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Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression

31 March 2020

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MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

31 March 2020

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Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.

31 March 2020

1 reference

Myeloid clusters are associated with a pro-metastatic environment and poor prognosis in smoking-related early stage non-small cell lung cancer

31 March 2020

1 reference

Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis

31 March 2020

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Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review

31 March 2020

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Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

31 March 2020

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Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers

31 March 2020

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Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

31 March 2020

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Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

31 March 2020

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31 March 2020

Stem cells: bad seeds

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

31 March 2020

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

31 March 2020

1 reference

Cancer stem cells: impact, heterogeneity, and uncertainty

31 March 2020

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Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

31 March 2020

1 reference

Stem Cells and Cancer: Two Faces of Eve

31 March 2020

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STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells

31 March 2020

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Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

31 March 2020

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Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

31 March 2020

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The genes for leukemia inhibitory factor and interleukin-6 are expressed in mouse blastocysts prior to the onset of hemopoiesis

31 March 2020

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LIF receptor signaling modulates neural stem cell renewal.

31 March 2020

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Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.

31 March 2020

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Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth

31 March 2020

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JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells

31 March 2020

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Interleukin 6 mediated recruitment of mesenchymal stem cells to the hypoxic tumor milieu

31 March 2020

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Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway

31 March 2020

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Differential regulation of myeloid leukemias by the bone marrow microenvironment

31 March 2020

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Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

31 March 2020

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Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal

31 March 2020

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Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells

31 March 2020

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Direct reprogramming of stem cell properties in colon cancer cells by CD44

31 March 2020

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Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

31 March 2020

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Stat3 dimerization regulated by reversible acetylation of a single lysine residue

31 March 2020

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Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA.

31 March 2020

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Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation

31 March 2020

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NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells

31 March 2020

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STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer

31 March 2020

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Histone deacetylase 3 as a novel therapeutic target in multiple myeloma.

31 March 2020

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JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

31 March 2020

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LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease

31 March 2020

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Function of mitochondrial Stat3 in cellular respiration

31 March 2020

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Toward a new STATe: the role of STATs in mitochondrial function

31 March 2020

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Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

31 March 2020

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Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727

31 March 2020

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Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice

31 March 2020

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Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

31 March 2020

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Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway

31 March 2020

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In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

31 March 2020

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TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo

31 March 2020

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Intestinal epithelial cells: regulators of barrier function and immune homeostasis

31 March 2020

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Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

31 March 2020

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STAT3 and its activators in intestinal defense and mucosal homeostasis.

31 March 2020

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Fine-tuning of GPCR activity by receptor-interacting proteins

31 March 2020

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Toll-like receptors and cancer

31 March 2020

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A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.

31 March 2020

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Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

31 March 2020

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Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation

31 March 2020

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Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells

31 March 2020

1 reference

MiR-135a targets JAK2 and inhibits gastric cancer cell proliferation

31 March 2020

1 reference

An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis

31 March 2020

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Serum interleukin 6 as a prognostic factor in patients with prostate cancer

31 March 2020

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12 December 2020

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

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12 December 2020

Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention

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12 December 2020

Adipokine regulation of colon cancer: adiponectin attenuates interleukin-6-induced colon carcinoma cell proliferation via STAT-3

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12 December 2020

Toll-like Receptors in Regulatory T Cells of Patients With Head and Neck Cancer

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12 December 2020

Identifiers

DOI

10.1038/NRC3818

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Dimensions Publication ID

1 September 2017

1014076105

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Fatcat ID

release_omqfobof6fh6ndquaqecosqhpm

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Fatcat

https://api.fatcat.wiki/v0/release/omqfobof6fh6ndquaqecosqhpm

24 November 2022

mapped directly with Wikidata item

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