Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease. (Q38447132)

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22 February 2020

title

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease (English)

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22 February 2020

0 references

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22 February 2020

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Marcy E MacDonald

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22 February 2020

author name string

William M Pryor

1

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22 February 2020

Neelam Shahani

3

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22 February 2020

Supriya Swarnkar

4

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22 February 2020

Wen-Chin Huang

5

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22 February 2020

Damon T Page

6

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22 February 2020

Srinivasa Subramaniam

8

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22 February 2020

publication date

28 October 2014

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22 February 2020

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22 February 2020

volume

7

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22 February 2020

issue

349

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22 February 2020

page(s)

ra103

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

22 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

HEAT repeats in the Huntington's disease protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Attenuation of Rhes activity significantly delays the appearance of behavioral symptoms in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Golgi protein ACBD3 mediates neurotoxicity associated with Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Regulation of TORC1 by Rag GTPases in nutrient response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Regulation of the small GTPase Rheb by amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Mechanisms of amino acid sensing in mTOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Multiple phenotypes in Huntington disease mouse neural stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

mTOR phosphorylated at S2448 binds to raptor and rictor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Where is mTOR and what is it doing there?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Termination of autophagy and reformation of lysosomes regulated by mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Huntingtin localization in brains of normal and Huntington's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

The role of chaperone-mediated autophagy in huntingtin degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Regulation of mTORC1 signaling by pH

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Huntingtin facilitates dynein/dynactin-mediated vesicle transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Rheb binds and regulates the mTOR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

mTOR signaling in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Making new contacts: the mTOR network in metabolism and signalling crosstalk

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Huntingtin as an essential integrator of intracellular vesicular trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Regulation of mTORC1 by the Rab and Arf GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

mTOR is a key modulator of ageing and age-related disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Fighting neurodegeneration with rapamycin: mechanistic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Huntington's disease is a disorder of the corpus striatum: focus on Rhes (Ras homologue enriched in the striatum)

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Regulation of mTORC1 by amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Inactivation of the mouse Huntington's disease gene homolog Hdh

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633

Rheb GTPase regulates β-secretase levels and amyloid β generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005633