The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target (Q38852028)

7 September 2017

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title

The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target (English)

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7 September 2017

Xiao Zhen Zhou

1

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7 September 2017

Kun Ping Lu

series ordinal

2

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7 September 2017

language of work or name

English

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publication date

3 June 2016

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7 September 2017

Nature Reviews Cancer

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7 September 2017

16

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7 September 2017

7

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7 September 2017

463-478

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https://scigraph.springernature.com/pub.10.1038/nrc.2016.49

7 September 2017

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cites work

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Mechanisms of specificity in protein phosphorylation

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Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

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Cyclin-dependent kinases: engines, clocks, and microprocessors

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The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

21 January 2018

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Prolyl cis-trans isomerization as a molecular timer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.49

Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.49

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase Pin1 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.49

Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pinning down proline-directed phosphorylation signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pinning down cell signaling, cancer and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The rs2233678 polymorphism in PIN1 promoter region reduced cancer risk: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

A Pin1/mutant p53 axis promotes aggressiveness in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1: a molecular orchestrator in the heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl cis/trans isomerase signalling pathways in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

A human peptidyl-prolyl isomerase essential for regulation of mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Function of WW domains as phosphoserine- or phosphothreonine-binding modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Evidence that the substrate backbone conformation is critical to phosphorylation by p42 MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

PIN1, the cell cycle and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 allows for differential Tau dephosphorylation in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prevalent overexpression of prolyl isomerase Pin1 in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

PIN1 promoter polymorphisms are associated with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Regulation of the microRNA 200b (miRNA-200b) by transcriptional regulators PEA3 and ELK-1 protein affects expression of Pin1 protein to control anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

TPA-induced cell transformation provokes a complex formation between Pin1 and 90 kDa ribosomal protein S6 kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The death-associated protein kinases: structure, function, and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Polo-like kinases and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 expression contributes to lung cancer: Prognosis and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

PIN1 expression contributes to hepatic carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Induction of cells with cancer stem cell properties from nontumorigenic human mammary epithelial cells by defined reprogramming factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Acute promyelocytic leukaemia: novel insights into the mechanisms of cure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Positive and negative regulation of granulopoiesis by endogenous RARalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

PML targeting eradicates quiescent leukaemia-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Phosphorylation stabilizes Nanog by promoting its interaction with Pin1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

A distinct role for Pin1 in the induction and maintenance of pluripotency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Induced pluripotency: history, mechanisms, and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Phosphorylation-specific prolyl isomerization: is there an underlying theme?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Androgen receptor serine 81 mediates Pin1 interaction and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Regulation of Raf-1 by direct feedback phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The prolyl isomerase Pin1 interacts with a ribosomal protein S6 kinase to enhance insulin-induced AP-1 activity and cellular transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Steroid receptor phosphorylation: a key modulator of multiple receptor functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Dual function of Pin1 in NR4A nuclear receptor activation: enhanced activity of NR4As and increased Nur77 protein stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The peptidyl-prolyl isomerase Pin1 regulates phospho-Ser77 retinoic acid receptor alpha stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase Pin1 downregulates tumor suppressor RUNX3 in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase Pin1 negatively regulates the stability of SUV39H1 to promote tumorigenesis in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Destabilization of KLF10, a tumor suppressor, relies on thr93 phosphorylation and isomerase association

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Control of cell cycle transcription during G1 and S phases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Targets of the cyclin-dependent kinase Cdk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(betatrcp).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 acts catalytically to promote a conformational change in Cdc25.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 modulates the dephosphorylation of the RNA polymerase II C-terminal domain by yeast Fcp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 modulates RNA polymerase II activity during the transcription cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The prolyl isomerase Pin1 functions in mitotic chromosome condensation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 modulates p63α protein stability in regulation of cell survival, proliferation and tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

21 January 2018

Hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The cellular peptidyl-prolyl cis/trans isomerase Pin1 regulates reactivation of Kaposi's sarcoma-associated herpesvirus from latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

SCP phosphatases suppress renal cell carcinoma by stabilizing PML and inhibiting mTOR/HIF signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Principles of cancer therapy: oncogene and non-oncogene addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Acquired resistance to tyrosine kinase inhibitors during cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Cancer genomics: one cell at a time

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial-mesenchymal transition phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 regulates the timing of mammalian primordial germ cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Spermatogonial depletion in adult Pin1-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 inhibitors: Pitfalls, progress and cellular pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Epigallocatechin-gallate Suppresses Tumorigenesis by Directly Targeting Pin1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Structure-based design of novel human Pin1 inhibitors (I)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Structure-guided design of alpha-amino acid-derived Pin1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Conformationally locked isostere of phosphoSer-cis-Pro inhibits Pin1 23-fold better than phosphoSer-trans-Pro isostere

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 as an anticancer drug target

21 January 2018

2 references

https://api.crossref.org/works/10.1038%2FNRC.2016.49

21 January 2018

12 December 2020

Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Structural Basis for High-Affinity Peptide Inhibition of Human Pin1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Membrane permeable cyclic peptidyl inhibitors against human Peptidylprolyl Isomerase Pin1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Structure-based design of novel human Pin1 inhibitors (II)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Randomized phase II trial of All-trans-retinoic acid with chemotherapy based on paclitaxel and cisplatin as first-line treatment in patients with advanced non-small-cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Randomized phase III trial comparing bexarotene (L1069-49)/cisplatin/vinorelbine with cisplatin/vinorelbine in chemotherapy-naive patients with advanced or metastatic non-small-cell lung cancer: SPIRIT I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Randomized double-blind 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in high-risk premenopausal women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Molecular pathways: current role and future directions of the retinoic acid pathway in cancer prevention and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Acute promyelocytic leukemia: from highly fatal to highly curable

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Single-agent liposomal all-trans-retinoic Acid as initial therapy for acute promyelocytic leukemia: 13-year follow-up data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

mTOR kinase structure, mechanism and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pleiotropic roles in cancer biology for multifaceted proteins FKBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl isomerase cyclophilin A regulation of Janus-activated kinase 2 and the progression of human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Cyclophilin B expression is associated with in vitro radioresistance and clinical outcome after radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

A critical step for JNK activation: isomerization by the prolyl isomerase Pin1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Dipeptidyl peptidase 4 promotes epithelial cell transformation and breast tumourigenesis via induction of PIN1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Pin1 is required for the Ser727 phosphorylation-dependent Stat3 activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Linking calcineurin activity to leukemogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The cleavage fragment of retinoid X receptor-alpha ligand binding domain inhibits radiosensitization by retinoic acid.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

Incidence of de-novo breast cancer in women chronically immunosuppressed after organ transplantation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.49

The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer.

31 March 2020

1 reference

12 December 2020

Cyclosporin A and sanglifehrin A enhance chemotherapeutic effect of cisplatin in C6 glioma cells.

1 reference

12 December 2020

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

1 reference

12 December 2020

Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia

1 reference

12 December 2020

Phase I/II trial of all-trans retinoic acid and tamoxifen in patients with advanced breast cancer

1 reference

12 December 2020

The prolyl isomerase Pin1 interacts with and downregulates the activity of AMPK leading to induction of tumorigenicity of hepatocarcinoma cells

1 reference

12 December 2020

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1 reference

12 December 2020

Retinoic acid modulates a bimodal effect on cell cycle progression in human adult T-cell leukemia cells

1 reference

12 December 2020

Activation of retinoic acid receptor alpha is sufficient for full induction of retinoid responses in SK-BR-3 and T47D human breast cancer cells.

1 reference

12 December 2020

Prolyl isomerase PIN1 negatively regulates SGK1 stability to mediate tamoxifen resistance in breast cancer cells

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC.2016.49

1 reference

Dimensions Publication ID

7 September 2017

0 references

1 reference