Manipulation of autophagy in cancer cells: an innovative strategy to fight drug resistance (Q39407829)

11 September 2017

Manipulation of autophagy in cancer cells: an innovative strategy to fight drug resistance (English)

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11 September 2017

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2

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11 September 2017

Francesca Aredia

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11 September 2017

1 June 2013

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Future Medicinal Chemistry

11 September 2017

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11 September 2017

5

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11 September 2017

1009-1021

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11 September 2017

9

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Targeted manipulation of apoptosis in cancer treatment

11 September 2017

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Apoptosis: a way to maintain healthy individuals

21 January 2018

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Killing of tumor cells: a drama in two acts

21 January 2018

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Conversation between apoptosis and autophagy: "Is it your turn or mine?".

21 January 2018

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Autophagy in mammalian development and differentiation

21 January 2018

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Autophagy: principles and significance in health and disease

21 January 2018

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Autophagy: from phenomenology to molecular understanding in less than a decade

21 January 2018

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Autophagy fights disease through cellular self-digestion

21 January 2018

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Eaten alive: a history of macroautophagy

21 January 2018

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Autophagy--alias self-eating--appetite and ageing

21 January 2018

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Janus-faced autophagy: a dual role of cellular self-eating in neurodegeneration?

21 January 2018

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Life, death and burial: multifaceted impact of autophagy

21 January 2018

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Autophagic cell death: Loch Ness monster or endangered species?

21 January 2018

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Hypoxia-induced autophagy: cell death or cell survival?

21 January 2018

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Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

21 January 2018

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Modulation of autophagic activity by extracellular pH.

21 January 2018

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The dynamic nature of autophagy in cancer

21 January 2018

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Autophagy and tumorigenesis

21 January 2018

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Autophagy and disease: always two sides to a problem

21 January 2018

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To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation

21 January 2018

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Autophagy mediates the mitotic senescence transition

21 January 2018

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The interplay between autophagy and ROS in tumorigenesis

21 January 2018

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The cell biology of cell-in-cell structures

21 January 2018

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Type 2 transglutaminase in neurodegenerative diseases: the mitochondrial connection

21 January 2018

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Survival features of EBV-stabilized cells from centenarians: morpho-functional and transcriptomic analyses

21 January 2018

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Autophagy and phagocytosis-like cell cannibalism exert opposing effects on cellular survival during metabolic stress.

21 January 2018

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Mechanisms of ploidy increase in human cancers: a new role for cell cannibalism

21 January 2018

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Autophagosome formation: core machinery and adaptations

21 January 2018

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The regulation of autophagy - unanswered questions

21 January 2018

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TOR-dependent control of autophagy: biting the hand that feeds

21 January 2018

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The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

21 January 2018

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Unleashing the Ambra1-Beclin 1 complex from dynein chains: Ulk1 sets Ambra1 free to induce autophagy

21 January 2018

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Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life

21 January 2018

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Regulation mechanisms and signaling pathways of autophagy

21 January 2018

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

21 January 2018

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Network organization of the human autophagy system

21 January 2018

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Autophagy suppresses tumor progression by limiting chromosomal instability

21 January 2018

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A dual role for UVRAG in maintaining chromosomal stability independent of autophagy

21 January 2018

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The autophagic paradox in cancer therapy

21 January 2018

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Molecular machinery of macroautophagy and its deregulation in diseases.

21 January 2018

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Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors

21 January 2018

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Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde?

21 January 2018

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Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability

21 January 2018

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Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability

21 January 2018

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Decreased expression of light chain 3 (LC3) increased the risk of distant metastasis in triple-negative breast cancer

21 January 2018

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Autophagy-deficient mice develop multiple liver tumors

21 January 2018

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Autophagy suppresses tumorigenesis through elimination of p62

21 January 2018

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A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

21 January 2018

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Therapeutic targets in cancer cell metabolism and autophagy

21 January 2018

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Bcl-2 family members: dual regulators of apoptosis and autophagy

21 January 2018

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Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells

21 January 2018

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Molecular aspects of cancer cell resistance to chemotherapy

21 January 2018

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Bif-1/endophilin B1: a candidate for crescent driving force in autophagy

21 January 2018

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Autophagy: a targetable linchpin of cancer cell metabolism

21 January 2018

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Autophagy as a target for anticancer therapy

21 January 2018

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Autophagy and ionizing radiation in tumors: the "survive or not survive" dilemma

21 January 2018

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Multi-timescale dynamics study of FKBP12 along the rapamycin-mTOR binding coordinate.

21 January 2018

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Emerging roles for mammalian target of rapamycin inhibitors in the treatment of solid tumors and hematological malignancies

21 January 2018

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Targeting mTOR pathways in human malignancies

21 January 2018

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Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia

21 January 2018

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A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

21 January 2018

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Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.

21 January 2018

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Akt and autophagy cooperate to promote survival of drug-resistant glioma

21 January 2018

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NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

21 January 2018

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Studies of NVP-BEZ235 in melanoma

21 January 2018

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The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk

21 January 2018

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Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'?

21 January 2018

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Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer

21 January 2018

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Targeting cancer cells through autophagy for anticancer therapy

21 January 2018

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Recent clinical trials of mTOR-targeted cancer therapies

21 January 2018

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mTOR inhibitors in cancer therapy.

21 January 2018

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Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells

21 January 2018

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Principles and current strategies for targeting autophagy for cancer treatment

21 January 2018

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Fighting neurodegeneration with rapamycin: mechanistic insights

21 January 2018

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21 January 2018

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Autophagy for tissue homeostasis and neuroprotection

21 January 2018

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Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Sträussler-Scheinker disease

21 January 2018

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Autophagy and polyglutamine diseases

21 January 2018

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Ubiquitin-dependent mitochondrial protein degradation

21 January 2018

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21 January 2018

Mechanisms of mitophagy

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PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity

21 January 2018

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A role for ubiquitin in selective autophagy

21 January 2018

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Ubiquitin: same molecule, different degradation pathways

21 January 2018

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Molecular crosstalk between the proteasome, aggresomes and autophagy: translational potential and clinical implications

21 January 2018

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Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy

21 January 2018

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Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives

21 January 2018

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Autophagy-independent enhancing effects of Beclin 1 on cytotoxicity of ovarian cancer cells mediated by proteasome inhibitors

21 January 2018

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Beclin 1 enhances proteasome inhibition-mediated cytotoxicity of thyroid cancer cells in macroautophagy-independent manner

21 January 2018

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Angiogenesis: an organizing principle for drug discovery?

21 January 2018

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Cancer prevention by targeting angiogenesis

21 January 2018

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Resveratrol, a phytochemical inducer of multiple cell death pathways: apoptosis, autophagy and mitotic catastrophe

21 January 2018

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3,4-Dimethoxystilbene, a resveratrol derivative with anti-angiogenic effect, induces both macroautophagy and apoptosis in endothelial cells

21 January 2018

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Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells

21 January 2018

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Hypoxia-induced tumor cell autophagy mediates resistance to anti-angiogenic therapy

21 January 2018

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Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies

21 January 2018

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p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation.

21 January 2018

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p53 post-translational modification: deregulated in tumorigenesis

21 January 2018

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p53 and autophagy in cancer: guardian of the genome meets guardian of the proteome

21 January 2018

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p53 signaling and autophagy in cancer: a revolutionary strategy could be developed for cancer treatment

21 January 2018

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Autophagy, senescence, and apoptosis

21 January 2018

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Directing p53 to induce autophagy

21 January 2018

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DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

21 January 2018

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Regulation of autophagy by cytoplasmic p53

21 January 2018

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Mitochondrial liaisons of p53.

21 January 2018

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Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis.

21 January 2018

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The impact of acetylation and deacetylation on the p53 pathway

21 January 2018

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HDAC inhibitor modulation of proteotoxicity as a therapeutic approach in cancer

21 January 2018

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Curbing autophagy and histone deacetylases to kill cancer cells

21 January 2018

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Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors

21 January 2018

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HDACs link the DNA damage response, processing of double-strand breaks and autophagy

21 January 2018

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Acetylation: a novel link between double-strand break repair and autophagy

21 January 2018

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Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy

21 January 2018

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The p53-induced gene Ei24 is an essential component of the basal autophagy pathway

21 January 2018

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Autophagy and tumor cell invasion

21 January 2018

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Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

21 January 2018

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Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance

21 January 2018

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Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

21 January 2018

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The double-edged sword of autophagy modulation in cancer

21 January 2018

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Pancreatic cancers require autophagy for tumor growth

21 January 2018

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Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent

21 January 2018

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Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?

21 January 2018

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MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

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MicroRNAs: a new class of gene regulators.

21 January 2018

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Context effect: microRNA-10b in cancer cell proliferation, spread and death

21 January 2018

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Autophagy regulation by miRNAs: when cleaning goes out of service

21 January 2018

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21 January 2018

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MicroRNA regulation of autophagy

21 January 2018

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MicroRNA-modulated autophagic signaling networks in cancer

21 January 2018

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MicroRNA: a third dimension in autophagy

21 January 2018

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The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy.

21 January 2018

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Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell

21 January 2018

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Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells.

21 January 2018

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microRNA-101 is a potent inhibitor of autophagy

21 January 2018

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Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells

21 January 2018

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miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1.

21 January 2018

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miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells

21 January 2018

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miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions

21 January 2018

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Selective autophagy degrades DICER and AGO2 and regulates miRNA activity

21 January 2018

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Degradation of the antiviral component ARGONAUTE1 by the autophagy pathway

21 January 2018

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Subcellular fate and off-target effects of siRNA, shRNA, and miRNA.

21 January 2018

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Formulation approaches to short interfering RNA and MicroRNA: challenges and implications.

21 January 2018

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Cell death by autophagy: facts and apparent artefacts

21 January 2018

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Autophagy in immunity and inflammation

21 January 2018

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21 January 2018

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Cell death pathology: cross-talk with autophagy and its clinical implications

21 January 2018

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Autophagy modulation as a potential therapeutic target for diverse diseases

21 January 2018

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Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity

21 January 2018

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Regulation of autophagy in mammals and its interplay with apoptosis.

21 January 2018

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Systems biology analysis of programmed cell death

21 January 2018

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A systems biology viewpoint on autophagy in health and disease

21 January 2018

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Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

21 January 2018

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Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

21 January 2018

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Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

21 January 2018

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Molecular mechanisms of necroptosis: an ordered cellular explosion

21 January 2018

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Killing a cancer: what are the alternatives?

21 January 2018

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Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.13.85

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11 September 2017

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PubMed ID

23734684