Role of ceramide in diabetes mellitus: evidence and mechanisms. (Q30351934)

13 November 2017

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13 March 2019

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4 February 2021

Role of ceramide in diabetes mellitus: evidence and mechanisms. (English)

1 reference

13 November 2017

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13 March 2019

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7 November 2019

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20 November 2019

7 references

30 June 2019

7 November 2019

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4 February 2021

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Faisal Thayyullathil

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13 November 2017

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Siraj Pallichankandy

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13 November 2017

Sehamuddin Galadari

1

1 reference

13 November 2017

Anees Rahman

series ordinal

2

1 reference

13 November 2017

Alaa Galadari

series ordinal

4

1 reference

13 November 2017

language of work or name

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8 July 2013

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Lipids in Health and Disease

13 November 2017

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30 June 2019

7 November 2019

17 November 2019

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20 November 2019

4 February 2021

11 references

13 November 2017

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14 March 2019

24 March 2019

30 June 2019

7 November 2019

17 November 2019

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Creative Commons Attribution 2.0 Generic

13 November 2017

10 references

13 March 2019

14 March 2019

24 March 2019

30 June 2019

7 November 2019

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19 November 2019

20 November 2019

on focus list of Wikimedia project

4 February 2021

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Ceramide formation as a target in beta-cell survival and function

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Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

3 June 2018

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Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance

3 June 2018

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A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.

3 June 2018

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Reactive oxygen species and insulin resistance: the good, the bad and the ugly

3 June 2018

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Palmitate induces apoptosis in Schwann cells via both ceramide-dependent and independent pathways

3 June 2018

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Glucose regulation of β‐cell stress in type 2 diabetes

3 June 2018

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Evaluation of sphingolipid metabolism in renal cortex of rats with streptozotocin-induced diabetes and the effects of rapamycin

3 June 2018

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3 June 2018

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Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors

3 June 2018

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Role of PUFAs, the precursors of endocannabinoids, in human obesity and type 2 diabetes

3 June 2018

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JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction

3 June 2018

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Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death

3 June 2018

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Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic beta-cells

3 June 2018

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Glycosphingolipids--nature, function, and pharmacological modulation.

3 June 2018

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Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function

3 June 2018

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Endoplasmic reticulum stress in beta-cells and development of diabetes

3 June 2018

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Disulfide formation in the ER and mitochondria: two solutions to a common process.

3 June 2018

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Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet beta-cells.

3 June 2018

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Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

3 June 2018

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Beta cell apoptosis in diabetes

3 June 2018

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Glycosphingolipids and insulin resistance.

3 June 2018

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Recent progress in research on beta-cell apoptosis by cytokines

3 June 2018

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Association of NAD(P)H oxidase with glucose-induced insulin secretion by pancreatic beta-cells.

3 June 2018

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Bioactive sphingolipids: metabolism and function

3 June 2018

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Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

3 June 2018

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Ceramide-enriched membrane domains--structure and function

3 June 2018

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Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression

3 June 2018

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The endocannabinoid system in obesity and type 2 diabetes.

3 June 2018

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Deregulation of sphingolipid metabolism in Alzheimer's disease

3 June 2018

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Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

3 June 2018

1 reference

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The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes

3 June 2018

1 reference

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Sphingolipid signalling in the cardiovascular system: good, bad or both?

3 June 2018

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Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited

3 June 2018

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Principles of bioactive lipid signalling: lessons from sphingolipids

3 June 2018

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Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells

3 June 2018

1 reference

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The sphingolipid salvage pathway in ceramide metabolism and signaling

3 June 2018

1 reference

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Apoptosis: controlled demolition at the cellular level

3 June 2018

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The role for endoplasmic reticulum stress in diabetes mellitus

3 June 2018

1 reference

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Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

3 June 2018

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Aging up-regulates expression of inflammatory mediators in mouse adipose tissue

3 June 2018

1 reference

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Diabetic cardiomyopathy revisited

3 June 2018

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Serum retinol-binding protein: a link between obesity, insulin resistance, and type 2 diabetes

3 June 2018

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Biological aspects of ceramide-enriched membrane domains

3 June 2018

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Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia

3 June 2018

1 reference

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

3 June 2018

1 reference

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

3 June 2018

1 reference

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Pioglitazone induces de novo ceramide synthesis in the rat heart

3 June 2018

1 reference

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Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy

3 June 2018

1 reference

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Exercise for type 2 diabetes mellitus

3 June 2018

1 reference

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Sphingolipid metabolism diseases

3 June 2018

1 reference

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Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations

3 June 2018

1 reference

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Ceramides in insulin resistance and lipotoxicity

3 June 2018

1 reference

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Insulin signaling and the regulation of glucose transport.

3 June 2018

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Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines

3 June 2018

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Apoptotic pathways: ten minutes to dead

3 June 2018

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Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis

3 June 2018

1 reference

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Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines

3 June 2018

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Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.

3 June 2018

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Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice

3 June 2018

1 reference

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Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

3 June 2018

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A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome

3 June 2018

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Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

3 June 2018

1 reference

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Molecular mechanisms of caspase regulation during apoptosis

3 June 2018

1 reference

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A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.

3 June 2018

1 reference

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The complex life of simple sphingolipids

3 June 2018

1 reference

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Serum tumor necrosis factor-alpha levels and components of the metabolic syndrome in obese adolescents

3 June 2018

1 reference

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Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

3 June 2018

1 reference

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Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

3 June 2018

1 reference

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Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells

3 June 2018

1 reference

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NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase

3 June 2018

1 reference

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Caspase-12 and ER-stress-mediated apoptosis: the story so far.

3 June 2018

1 reference

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The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase

3 June 2018

1 reference

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Inflammation: the link between insulin resistance, obesity and diabetes

3 June 2018

1 reference

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Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

3 June 2018

1 reference

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A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Lipoapoptosis: its mechanism and its diseases

3 June 2018

1 reference

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Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3.

3 June 2018

1 reference

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Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

3 June 2018

1 reference

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A central role for JNK in obesity and insulin resistance

3 June 2018

1 reference

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IRS proteins and the common path to diabetes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Mitochondria and ceramide: intertwined roles in regulation of apoptosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

The mode of action of thiazolidinediones

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Sphingolipids in mammalian cell signalling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

beta-Cell death during progression to diabetes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide enables fas to cap and kill.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Tumor necrosis factor alpha signaling pathway and apoptosis in pancreatic beta cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sen

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Activation of the sphingomyelinase/ceramide signal transduction pathway in insulin-secreting beta-cells: role in cytokine-induced beta-cell death

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Reactive oxygen species enhances the induction of inducible nitric oxide synthase by sphingomyelinase in RAW264.7 cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Bcl-2 expression causes redistribution of glutathione to the nucleus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Fatty acid-induced insulin resistance in adipocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

The insulin signaling system

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Effects of pioglitazone and high-fat diet on ceramide metabolism in rat skeletal muscles.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Positively charged ceramide is a potent inducer of mitochondrial permeabilization.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

a-Series gangliosides mediate the effects of advanced glycation end products on pericyte and mesangial cell proliferation: a common mediator for retinal and renal microangiopathy?

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Endostatin uncouples NO and Ca2+ response to bradykinin through enhanced O2*- production in the intact coronary endothelium

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Effect of endurance training on the sphingomyelin-signalling pathway activity in the skeletal muscles of the rat.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Exercise and training effects on ceramide metabolism in human skeletal muscle.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

The role of endoplasmic reticulum stress in nonimmune diabetes: NOD.k iHEL, a novel model of beta cell death.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Lipotoxicity in human pancreatic islets and the protective effect of metformin

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3716967

A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis

26 November 2018

1 reference

12 December 2020

Key role for ceramides in mediating insulin resistance in human muscle cells

1 reference

12 December 2020

Cell-permeable ceramides increase basal glucose incorporation into triacylglycerols but decrease the stimulation by insulin in 3T3-L1 adipocytes

1 reference

12 December 2020

Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide

1 reference

12 December 2020

Secretory Zn2+-dependent sphingomyelinase activity in the serum of patients with type 2 diabetes is elevated

1 reference

12 December 2020

Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance

1 reference

12 December 2020

Ceramide Interaction with the Respiratory Chain of Heart Mitochondria†

1 reference

12 December 2020

Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but does not prevent autoimmune destruction

1 reference

12 December 2020

Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models

1 reference

12 December 2020

Role of apoptosis in pancreatic beta-cell death in diabetes

1 reference

12 December 2020

Ceramide inhibits pancreatic β‐cell insulin production and mitogenesis and mimics the actions of interleukin‐1β

1 reference

12 December 2020

Insulin signalling: the role of insulin receptor substrate 1

1 reference

12 December 2020

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

12 December 2020

Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1

1 reference

12 December 2020

Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes

1 reference

12 December 2020

Identifiers

DOI

10.1186/1476-511X-12-98

1 reference

Dimensions Publication ID

13 November 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1476-511x-12-98

1 reference

13 November 2017

PubMed publication ID

23835113

1 reference