Type 2 diabetes: genetic data sharing to advance complex disease research (Q30390388)

21 June 2017

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title

Type 2 diabetes: genetic data sharing to advance complex disease research (English)

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21 June 2017

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1 reference

Jason Flannick

1

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PubMed ID

27402621

21 June 2017

Jose C Florez

series ordinal

2

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21 June 2017

11 July 2016

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21 June 2017

Nature Reviews Genetics

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21 June 2017

17

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21 June 2017

535-549

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21 June 2017

9

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Familial risks for type 2 diabetes in Sweden

21 June 2017

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Excess Mortality among Persons with Type 2 Diabetes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genetic mapping in human disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genomics, type 2 diabetes, and obesity

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genetic heterogeneity in human disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Common genetic variation and human traits

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

The future of genetic studies of complex human diseases

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

On the allelic spectrum of human disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

A haplotype map of the human genome

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

A genome-wide association study identifies novel risk loci for type 2 diabetes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Practical aspects of imputation-driven meta-analysis of genome-wide association studies

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

METAL: fast and efficient meta-analysis of genomewide association scans

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Biological, clinical and population relevance of 95 loci for blood lipids

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Finding the missing heritability of complex diseases

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genomewide association studies--illuminating biologic pathways

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Rare variants create synthetic genome-wide associations

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Common and rare variants in multifactorial susceptibility to common diseases

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Are rare variants responsible for susceptibility to complex diseases?

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

The importance of synthetic associations will only be resolved empirically

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Synthetic associations are unlikely to account for many common disease genome-wide association signals

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Synthetic associations created by rare variants do not explain most GWAS results

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Evaluating empirical bounds on complex disease genetic architecture

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRG.2016.56

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Think zinc: New roles for zinc in the control of insulin secretion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

The genetic architecture of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Searching for missing heritability: designing rare variant association studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

A central role for GRB10 in regulation of islet function in man.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Bilirubin as a potential causal factor in type 2 diabetes risk: a Mendelian randomization study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

HDL Cholesterol and Risk of Type 2 Diabetes: A Mendelian Randomization Study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

PTEN deletion in pancreatic α-cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Identification of type 2 diabetes subgroups through topological analysis of patient similarity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

A metagenome-wide association study of gut microbiota in type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Metabolite traits and genetic risk provide complementary information for the prediction of future type 2 diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Circulating metabolite predictors of glycemia in middle-aged men and women

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Sixty-five common genetic variants and prediction of type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Polygenic type 2 diabetes prediction at the limit of common variant detection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Bayesian refinement of association signals for 14 loci in 3 common diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Validating therapeutic targets through human genetics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

An integrated encyclopedia of DNA elements in the human genome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Systematic localization of common disease-associated variation in regulatory DNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Chromatin marks identify critical cell types for fine mapping complex trait variants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

A map of open chromatin in human pancreatic islets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

ADCY5 couples glucose to insulin secretion in human islets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Targeted Allelic Expression Profiling in Human Islets Identifiescis-Regulatory Effects for Multiple Variants Identified by Type 2 Diabetes Genome-Wide Association Studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Obesity-associated variants within FTO form long-range functional connections with IRX3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Erratum: Corrigendum: Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Allele-specific transcriptional activity at type 2 diabetes-associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Insights into the molecular mechanism for type 2 diabetes susceptibility at the KCNQ1 locus from temporal changes in imprinting status in human islets.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Rfx6 directs islet formation and insulin production in mice and humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

The Lin28/let-7 axis regulates glucose metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

ClinVar: public archive of interpretations of clinically relevant variants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Human Gene Mutation Database (HGMD): 2003 update.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Human genotype-phenotype databases: aims, challenges and opportunities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

An integrated map of genetic variation from 1,092 human genomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

The UCSC Genome Browser database: 2015 update

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Analysis of protein-coding genetic variation in 60,706 humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Pharma firms join NIH on drug development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Using human genetics to make new medicines.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

The innovative medicines initiative: a European response to the innovation challenge

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Consent for genetics studies among clinical trial participants: findings from Action for Health in Diabetes (Look AHEAD).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

KCNQ1 long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.56

All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care through the Global Alliance for Genomics and Health

31 March 2020

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12 December 2020

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

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12 December 2020

Integrative analysis of 111 reference human epigenomes

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12 December 2020

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

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12 December 2020

Analysis of protein-coding genetic variation in 60,706 humans

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12 December 2020

A reference panel of 64,976 haplotypes for genotype imputation

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Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans

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Identifiers

DOI

10.1038/NRG.2016.56

1 reference

PubMed ID

27402621

Dimensions Publication ID

21 June 2017

0 references

1 reference

PubMed ID

27402621