On the role of IRS2 in the regulation of functional beta-cell mass (Q36576524)

15 August 2017

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title

On the role of IRS2 in the regulation of functional beta-cell mass (English)

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15 August 2017

Markus Niessen

1

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15 August 2017

1 April 2006

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Archives of Physiology and Biochemistry

15 August 2017

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15 August 2017

112

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15 August 2017

2

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15 August 2017

65-73

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The metabolisable hexoses D-glucose and D-mannose enhance the expression of IRS-2 but not of IRS-1 in pancreatic beta-cells

15 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Life and death of the pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

beta-cell turnover: its assessment and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600711409

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600711409

A transplantable insulinoma in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600711409

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600711409

Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600711409

Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600711409

Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600711409

cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600711409

Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600711409

The mechanism of insulin-induced signal transduction mediated by the insulin receptor substrate family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix: Modulation of B-Cell Function by Chronic Exposure to High Glucose*

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

The unfolded protein response in nutrient sensing and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Insulin receptor substrate 3 is not essential for growth or glucose homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600711409

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Modulation of insulin action.

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600711409

IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Type 2 diabetes-a matter of beta-cell life and death?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

ER stress and the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Genetic control of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

The insulin signalling system and the IRS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Protein kinase B alpha/Akt1 regulates placental development and fetal growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

Physiological functions of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600711409

10.1080/13813450600711409

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

16931448