Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells (Q37277467)

19 August 2017

1 reference

title

Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells (English)

1 reference

ubiquitin-proteasome system

19 August 2017

0 references

0 references

author name string

Taila Hartley

series ordinal

1

1 reference

PubMed ID

18812463

19 August 2017

John Brumell

series ordinal

2

1 reference

PubMed ID

18812463

19 August 2017

Allen Volchuk

series ordinal

3

1 reference

19 August 2017

23 September 2008

1 reference

American Journal of Physiology - Endocrinology and Metabolism

19 August 2017

1 reference

19 August 2017

296

1 reference

19 August 2017

E1-10

1 reference

19 August 2017

1

1 reference

Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1.

19 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Glucoreceptor mechanisms and the control of insulin release and biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

ER-phagy: selective autophagy of the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

IRS proteins and beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Autophagy is a prosurvival mechanism in cells expressing an autosomal dominant familial neurohypophyseal diabetes insipidus mutant vasopressin transgene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Localisation of islet amyloid peptide in lipofuscin bodies and secretory granules of human B-cells and in islets of type-2 diabetic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Autophagy and signaling: their role in cell survival and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Structure and functions of the 20S and 26S proteasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

The role of assembly in insulin's biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

The role of gut hormones in glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

The role for endoplasmic reticulum stress in diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Role of LAMP-2 in lysosome biogenesis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Endoplasmic reticulum stress signaling in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Ubiquitination system and autoimmunity: the bridge towards the modulation of the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic beta cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

U-box proteins as a new family of ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Inflammation and metabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

A ubiquitin-like system mediates protein lipidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

ERADicate ER stress or die trying

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Autophagy: from phenomenology to molecular understanding in less than a decade

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Aggresomes, inclusion bodies and protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Development by self-digestion: molecular mechanisms and biological functions of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Protein quality control: chaperones culling corrupt conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Regulation of insulin gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

ERAD: the long road to destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Insulin secretion and differential gene expression in glucose-responsive and -unresponsive MIN6 sublines

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

How the ubiquitin-proteasome system controls transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Ubiquitin ligases: cell-cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

The Ubi brothers reunited

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Fatty acid signaling in the beta-cell and insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Autophagy is activated for cell survival after endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Insulin, not C-peptide (proinsulin), is present in crinophagic bodies of the pancreatic B-cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

The role of autophagy in alpha-1-antitrypsin deficiency: a specific cellular response in genetic diseases associated with aggregation-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

1. Membrane origin for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Insulin granule dynamics in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

21 January 2018

All roads lead to ATF4

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Mapping of possible prion protein self-interaction domains using peptide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Stress, protein (mis)folding, and signaling: the redox connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

A ubiquitin-like protein involved in membrane fusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Critical nodes in signalling pathways: insights into insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Glucose regulation of gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Ubiquitin and ubiquitin-like proteins as multifunctional signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

A new pharmacology--drugging stressed folding pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Endoplasmic reticulum stress triggers autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90538.2008

10.1152/AJPENDO.90538.2008

21 January 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

18812463