A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage. (Q37339272)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19433585%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage (English)

1 reference

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27 January 2020

0 references

4

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27 January 2020

Anton M. Jetten

5

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27 January 2020

author name string

Jun Yan

1

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27 January 2020

Daniel Menendez

2

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27 January 2020

Xiao-Ping Yang

3

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27 January 2020

language of work or name

English

0 references

publication date

11 May 2009

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Journal of Biological Chemistry

27 January 2020

published in

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27 January 2020

volume

284

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27 January 2020

issue

29

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27 January 2020

page(s)

19280-19289

1 reference

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Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

27 January 2020

cites work

1 reference

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RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites

6 September 2017

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Transcriptional control of human p53-regulated genes

6 September 2017

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Functional evolution of the p53 regulatory network through its target response elements

6 September 2017

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NUMB controls p53 tumour suppressor activity

6 September 2017

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The DNA damage response pathways: at the crossroad of protein modifications

6 September 2017

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The DNA damage response: ten years after

6 September 2017

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

6 September 2017

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

6 September 2017

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

6 September 2017

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

6 September 2017

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Two faces of p53: aging and tumor suppression

6 September 2017

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The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

6 September 2017

1 reference

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DNA strand break repair and human genetic disease

6 September 2017

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How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?

6 September 2017

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The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response

6 September 2017

1 reference

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RAP80/UIMC1 as cancer-associated antigen: alternative splice variants and their immunogenicity.

6 September 2017

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Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

6 September 2017

1 reference

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RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

6 September 2017

1 reference

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Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

6 September 2017

1 reference

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Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson

6 September 2017

1 reference

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Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha.

6 September 2017

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

6 September 2017

1 reference

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DNA damage checkpoints: from initiation to recovery or adaptation

6 September 2017

1 reference

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A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1.

6 September 2017

1 reference

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The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes

6 September 2017

1 reference

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p53 ubiquitination: Mdm2 and beyond

6 September 2017

1 reference

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A global map of p53 transcription-factor binding sites in the human genome

6 September 2017

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The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

6 September 2017

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Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.

6 September 2017

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Cell-cycle checkpoints and cancer

6 September 2017

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Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

6 September 2017

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6 September 2017

1 reference

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Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.

6 September 2017

1 reference

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Genome maintenance mechanisms for preventing cancer

6 September 2017

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

6 September 2017

1 reference

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The DNA damage response: putting checkpoints in perspective

6 September 2017

1 reference

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

6 September 2017

1 reference

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740553

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740553

p53, the cellular gatekeeper for growth and division

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740553

The p53-mdm-2 autoregulatory feedback loop

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740553

Definition of a consensus binding site for p53

6 September 2017

1 reference

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Yin Yang 1 is a negative regulator of p53.

6 September 2017

1 reference

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A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740553

Evaluation of the BRCA1 interacting genes RAP80 and CCDC98 in familial breast cancer susceptibility.

14 September 2017

1 reference

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Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.

2 September 2018

1 reference

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Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

2 September 2018

1 reference

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Germline RAP80 mutations and susceptibility to breast cancer

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19433585

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.013102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19433585%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19433585%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference