FOXOs: signalling integrators for homeostasis maintenance (Q38074598)

28 August 2017

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title

FOXOs: signalling integrators for homeostasis maintenance (English)

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28 August 2017

Astrid Eijkelenboom

1

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PubMed ID

23325358

28 August 2017

Boudewijn M T Burgering

series ordinal

2

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28 August 2017

17 January 2013

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Nature Reviews Molecular Cell Biology

28 August 2017

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28 August 2017

14

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28 August 2017

83-97

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28 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrm3507

28 August 2017

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cites work

Stressing the role of FoxO proteins in lifespan and disease

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Unravelling the tumor-suppressive functions of FOXO proteins

31 March 2020

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31 March 2020

The genetics of ageing

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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

31 March 2020

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FoxO and stress responses in the cnidarian Hydra vulgaris

31 March 2020

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Integrating opposing signals toward Forkhead box O.

31 March 2020

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31 March 2020

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

31 March 2020

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The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

31 March 2020

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An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

31 March 2020

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Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

31 March 2020

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CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage

31 March 2020

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Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons

31 March 2020

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CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor

31 March 2020

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Dual role of CDKs in DNA repair: to be, or not to be.

31 March 2020

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

31 March 2020

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Functional interaction between FOXO3a and ATM regulates DNA damage response

31 March 2020

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Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.

31 March 2020

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The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

31 March 2020

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Novel repressor regulates insulin sensitivity through interaction with Foxo1

31 March 2020

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Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

31 March 2020

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Evolutionarily conserved protein arginine methyltransferases in non-mammalian animal systems

31 March 2020

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Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

31 March 2020

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Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.

31 March 2020

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Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death

31 March 2020

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O-GlcNAc regulates FoxO activation in response to glucose

31 March 2020

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O-GlcNAc modification of FoxO1 increases its transcriptional activity: a role in the glucotoxicity phenomenon?

31 March 2020

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Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

31 March 2020

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A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose

31 March 2020

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Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation

31 March 2020

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Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

31 March 2020

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The peroxide dilemma: opposing and mediating insulin action

31 March 2020

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Intrinsically unstructured proteins and their functions

31 March 2020

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p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

31 March 2020

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Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21

31 March 2020

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Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor

31 March 2020

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D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.

31 March 2020

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The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

31 March 2020

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The interaction between FOXO and SIRT1: tipping the balance towards survival

31 March 2020

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

31 March 2020

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Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice

31 March 2020

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FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

31 March 2020

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Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin

31 March 2020

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Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.

31 March 2020

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Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells

31 March 2020

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Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer

31 March 2020

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miR-139 impacts FoxO1 action by decreasing FoxO1 protein in mouse hepatocytes.

31 March 2020

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Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486

31 March 2020

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miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg

31 March 2020

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MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer

31 March 2020

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MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4

31 March 2020

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Foxo3a regulates apoptosis by negatively targeting miR-21

31 March 2020

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FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis

31 March 2020

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The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation

31 March 2020

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Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren's syndrome.

31 March 2020

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Identification of a common lupus disease-associated microRNA expression pattern in three different murine models of lupus

31 March 2020

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Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1

31 March 2020

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Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis

31 March 2020

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A hormone-dependent module regulating energy balance

31 March 2020

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FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

31 March 2020

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The transcriptional role of PML and the nuclear body

31 March 2020

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Mdm2 induces mono-ubiquitination of FOXO4

31 March 2020

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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

31 March 2020

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MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.

31 March 2020

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Phosphorylation of HDM2 by Akt.

31 March 2020

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

31 March 2020

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

31 March 2020

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

31 March 2020

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PML regulates p53 stability by sequestering Mdm2 to the nucleolus

31 March 2020

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Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization

31 March 2020

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Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells

31 March 2020

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A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles

31 March 2020

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Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins

31 March 2020

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Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

31 March 2020

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Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

31 March 2020

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14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

31 March 2020

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The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy

31 March 2020

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The E3 ligase TRAF6 regulates Akt ubiquitination and activation

31 March 2020

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The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

31 March 2020

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FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

31 March 2020

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Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

31 March 2020

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A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion

31 March 2020

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Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

31 March 2020

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Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

31 March 2020

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A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

31 March 2020

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Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma

31 March 2020

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Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty

31 March 2020

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Multiple modes of chromatin remodeling by Forkhead box proteins

31 March 2020

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Chromatin opening and stable perturbation of core histone:DNA contacts by FoxO1.

31 March 2020

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Acetylation curtails nucleosome binding, not stable nucleosome remodeling, by FoxO1.

31 March 2020

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FOXO-binding partners: it takes two to tango

31 March 2020

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p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

31 March 2020

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The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor.

31 March 2020

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FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.

31 March 2020

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Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a

31 March 2020

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The PKB/FOXO switch in aging and cancer

31 March 2020

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FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

31 March 2020

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FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function

31 March 2020

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Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression

31 March 2020

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Functional interaction between beta-catenin and FOXO in oxidative stress signaling

31 March 2020

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Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity

31 March 2020

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Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.

31 March 2020

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Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis

31 March 2020

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Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes

31 March 2020

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

31 March 2020

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LRP6 mutation in a family with early coronary disease and metabolic risk factors

31 March 2020

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The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression

31 March 2020

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SREBPs suppress IRS-2-mediated insulin signalling in the liver.

31 March 2020

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Transcriptional feedback control of insulin receptor by dFOXO/FOXO1.

31 March 2020

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FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

31 March 2020

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FoxO1, the transcriptional chief of staff of energy metabolism

31 March 2020

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FoxO1 target Gpr17 activates AgRP neurons to regulate food intake

31 March 2020

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Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

31 March 2020

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Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

31 March 2020

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Folding proteins in fatal ways

31 March 2020

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The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

31 March 2020

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Opposing activities protect against age-onset proteotoxicity

31 March 2020

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Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

31 March 2020

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RPN-6 determines C. elegans longevity under proteotoxic stress conditions

31 March 2020

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FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

31 March 2020

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FoxO3 controls autophagy in skeletal muscle in vivo

31 March 2020

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FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation

31 March 2020

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

31 March 2020

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Identification of ubiquitin ligases required for skeletal muscle atrophy

31 March 2020

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Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin

31 March 2020

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FoxO transcription factors promote autophagy in cardiomyocytes

31 March 2020

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Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

31 March 2020

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The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

31 March 2020

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Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway

31 March 2020

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FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle

31 March 2020

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Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans

31 March 2020

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FoxO is a critical regulator of stem cell maintenance in immortal Hydra

31 March 2020

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Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

31 March 2020

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FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

31 March 2020

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FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

31 March 2020

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FoxO3 regulates neural stem cell homeostasis

31 March 2020

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Nanog and transcriptional networks in embryonic stem cell pluripotency

31 March 2020

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FOXO1 is an essential regulator of pluripotency in human embryonic stem cells

31 March 2020

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FOXO-dependent regulation of innate immune homeostasis

31 March 2020

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FOXO transcription factors throughout T cell biology

31 March 2020

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Highly specialized role of Forkhead box O transcription factors in the immune system.

31 March 2020

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Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

31 March 2020

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Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

31 March 2020

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Foxo1 directly regulates the transcription of recombination-activating genes during B cell development

31 March 2020

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Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

31 March 2020

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Foxo transcription factors control regulatory T cell development and function

31 March 2020

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Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

31 March 2020

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Novel Foxo1-dependent transcriptional programs control T(reg) cell function

31 March 2020

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A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses

31 March 2020

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Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

31 March 2020

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Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.

31 March 2020

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TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

31 March 2020

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AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

31 March 2020

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Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors

31 March 2020

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

31 March 2020

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FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.

31 March 2020

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β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

31 March 2020

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The extending network of FOXO transcriptional target genes

31 March 2020

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Wnt signaling regulates hepatic metabolism

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23325358

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Should I stay or should I go: beta-catenin decides under stress

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23325358

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM3507

1 reference

PubMed ID

23325358

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23325358