T cell receptor signalling networks: branched, diversified and bounded (Q38092568)

28 August 2017

T cell receptor signalling networks: branched, diversified and bounded (English)

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28 August 2017

Rebecca J Brownlie

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Rose Zamoyska

object named as

Rose Zamoyska

series ordinal

2

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publication date

1 April 2013

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Nature Reviews Immunology

28 August 2017

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28 August 2017

13

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28 August 2017

4

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28 August 2017

257-269

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Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults.

28 August 2017

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Differential requirements for survival and proliferation of CD8 naïve or memory T cells

31 March 2020

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Homeostasis of naive and memory T cells

31 March 2020

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Regulation of peripheral T-cell homeostasis by receptor signalling

31 March 2020

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Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

31 March 2020

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Src family kinases, key regulators of signal transduction

31 March 2020

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T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

31 March 2020

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TCR signals mediated by Src family kinases are essential for the survival of naive T cells

31 March 2020

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Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

31 March 2020

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Tailoring T-cell receptor signals by proximal negative feedback mechanisms

31 March 2020

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

31 March 2020

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CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery

31 March 2020

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Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

31 March 2020

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TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling

31 March 2020

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The kinetic-segregation model: TCR triggering and beyond

31 March 2020

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Biophysical mechanism of T-cell receptor triggering in a reconstituted system

31 March 2020

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Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response

31 March 2020

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Structural basis for the inhibition of tyrosine kinase activity of ZAP-70

31 March 2020

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Structure and regulation of Src family kinases

31 March 2020

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Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

31 March 2020

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Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

31 March 2020

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Csk controls antigen receptor-mediated development and selection of T-lineage cells.

31 March 2020

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Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).

31 March 2020

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CD45: a critical regulator of signaling thresholds in immune cells

31 March 2020

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The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.

31 March 2020

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CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development

31 March 2020

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Requirement of the SH3 and SH2 domains for the inhibitory function of tyrosine protein kinase p50csk in T lymphocytes.

31 March 2020

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Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

31 March 2020

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Conformational states of the kinase Lck regulate clustering in early T cell signaling

31 March 2020

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Transmembrane adaptor proteins: organizers of immunoreceptor signalling

31 March 2020

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Differential polarization of C-terminal Src kinase between naive and antigen-experienced CD8+ T cells

31 March 2020

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Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling

31 March 2020

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Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

31 March 2020

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Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor

31 March 2020

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The ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and function

31 March 2020

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Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development

31 March 2020

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A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation

31 March 2020

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T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2

31 March 2020

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Dok-1 and Dok-2 are negative regulators of T cell receptor signaling

31 March 2020

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Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

31 March 2020

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Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

31 March 2020

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Ras signalling on the endoplasmic reticulum and the Golgi

31 March 2020

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Activation of the MAPK module from different spatial locations generates distinct system outputs

31 March 2020

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CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway

31 March 2020

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Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.

31 March 2020

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

31 March 2020

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The LAT story: a tale of cooperativity, coordination, and choreography

31 March 2020

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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

31 March 2020

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Essential role of LAT in T cell development

31 March 2020

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Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor

31 March 2020

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Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes

31 March 2020

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Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells

31 March 2020

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LAT signaling pathology: an "autoimmune" condition without T cell self-reactivity

31 March 2020

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LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.

31 March 2020

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SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond

31 March 2020

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Reciprocal signaling by integrin and nonintegrin receptors during collagen activation of platelets

31 March 2020

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The immunological synapse: a molecular machine controlling T cell activation

31 March 2020

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Three-dimensional segregation of supramolecular activation clusters in T cells

31 March 2020

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Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

31 March 2020

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

31 March 2020

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Signal initiation in T-cell receptor microclusters

31 March 2020

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New insights into the T cell synapse from single molecule techniques

31 March 2020

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TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

31 March 2020

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Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor

31 March 2020

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Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse

31 March 2020

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Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events

31 March 2020

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Cooperative interactions at the SLP-76 complex are critical for actin polymerization

31 March 2020

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Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

31 March 2020

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Spatiotemporal patterning during T cell activation is highly diverse

31 March 2020

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Itk controls the spatiotemporal organization of T cell activation

31 March 2020

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Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

31 March 2020

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Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response

31 March 2020

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The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

31 March 2020

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Tec family kinases in T lymphocyte development and function

31 March 2020

1 reference

T-cell receptor signaling to integrins

31 March 2020

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T-cell activation through immunological synapses and kinapses

31 March 2020

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Beta1 integrins: zip codes and signaling relay for blood cells

31 March 2020

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T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76

31 March 2020

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T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells

31 March 2020

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Regulating Rap small G-proteins in time and space

31 March 2020

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Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion.

31 March 2020

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Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

31 March 2020

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Regulation of beta 1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity

31 March 2020

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The insider's guide to leukocyte integrin signalling and function

31 March 2020

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T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes

31 March 2020

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A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

31 March 2020

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CD18 is required for optimal development and function of CD4+CD25+ T regulatory cells

31 March 2020

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Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo

31 March 2020

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T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

31 March 2020

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The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse

31 March 2020

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Continuous T cell receptor signaling required for synapse maintenance and full effector potential

31 March 2020

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Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase

31 March 2020

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Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.

31 March 2020

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PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

31 March 2020

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Role of PTPN22 in type 1 diabetes and other autoimmune diseases

31 March 2020

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A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

31 March 2020

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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

31 March 2020

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The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.

31 March 2020

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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

31 March 2020

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Foxp3 occupancy and regulation of key target genes during T-cell stimulation

31 March 2020

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Functional and quantitative proteomics using SILAC

31 March 2020

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A deep profiler's guide to cytometry

31 March 2020

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Cellular image analysis and imaging by flow cytometry

31 March 2020

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Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23524462

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI3403

1 reference

28 August 2017

1 reference

PubMed ID

23524462