Therapeutic strategies in Parkinson's disease: what we have learned from animal models (Q38290759)

1 September 2017

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title

Therapeutic strategies in Parkinson's disease: what we have learned from animal models (English)

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1 September 2017

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3

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1 September 2017

Jorge S Valadas

1

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author name string

Melissa Vos

series ordinal

2

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1 September 2017

language of work or name

English

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publication date

16 December 2014

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Annals of the New York Academy of Sciences

1 September 2017

published in

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1 September 2017

volume

1338

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1 September 2017

issue

1

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25 June 2019

page(s)

16-37

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Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.

1 September 2017

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Parkinson's disease: from genetics to treatments

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A review of Parkinson's disease

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Epidemiology of Parkinson's disease

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Rotenone, paraquat, and Parkinson's disease

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What genetics tells us about the causes and mechanisms of Parkinson's disease

21 January 2018

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α-synuclein, LRRK2 and their interplay in Parkinson's disease.

21 January 2018

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Chronic parkinsonism secondary to intravenous injection of meperidine analogues

21 January 2018

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Parkinson's disease: from monogenic forms to genetic susceptibility factors

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

Pars compacta of the substantia nigra modulates motor activity but is not involved importantly in regulating food and water intake

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

The role of α-synuclein in neurotransmission and synaptic plasticity

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

Synaptic dysfunction in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The synaptic function of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

Alpha-synuclein: from secretion to dysfunction and death

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

Genetics of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12577

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Neural activity controls the synaptic accumulation of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Binding of alpha-synuclein affects the lipid packing in bilayers of small vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Yeast cells provide insight into alpha-synuclein biology and pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Modulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

A Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Animal models of Parkinson's disease: limits and relevance to neuroprotection studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

In vitro aggregation assays for the characterization of α-synuclein prion-like properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Use of viral vectors to create animal models for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Α-synuclein misfolding and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

LRRK2 low-penetrance mutations (Gly2019Ser) and risk alleles (Gly2385Arg)-linking familial and sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The structural era of endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The dardarin G 2019 S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Biochemical and pathological characterization of Lrrk2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Lrrk2 and Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Spread of neuronal degeneration in a dopaminergic, Lrrk-G2019S model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Generation of high curvature membranes mediated by direct endophilin bilayer interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Interplay of LRRK2 with chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Failure of the ubiquitin-proteasome system in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Chaperone-mediated autophagy: roles in disease and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Defective autophagy in Parkinson's disease: role of oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Immunotherapy for neurodegenerative diseases: focus on α-synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The role of mitochondrial function and cellular bioenergetics in ageing and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Role of mitochondria in neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The formation of reactive intermediates in the MAO-catalyzed oxidation of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and methamphetamine in several strains of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Protocol for the MPTP mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Chronic intraventricular administration of 1-methyl-4-phenylpyridinium as a progressive model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Modeling Parkinson's disease in primates: The MPTP model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Selective loss of subpopulations of ventral mesencephalic dopaminergic neurons in the monkey following exposure to MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parkinsonian rotenone mouse model: reevaluation of long-term administration of rotenone in C57BL/6 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Rotenone induces degeneration of photoreceptors and impairs the dopaminergic system in the rat retina.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Early-onset Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parkin and PINK1: much more than mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parkin and mitochondrial quality control: toward assembling the puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Dopamine covalently modifies and functionally inactivates parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parkin-deficient mice are not a robust model of parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Loss of locus coeruleus neurons and reduced startle in parkin null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Aconitase causes iron toxicity in Drosophila pink1 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Recent advances in the genetics of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Functional recovery in parkinsonian monkeys treated with GDNF

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The ubiquitin pathway in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Analysis of alpha-synuclein-associated proteins by quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The mitochondrial serine protease HtrA2/Omi: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Essential role of phosphoinositide metabolism in synaptic vesicle recycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Mutations in synaptojanin disrupt synaptic vesicle recycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Dopaminergic neuronal dysfunction associated with parkinsonism in both a Gaucher disease patient and a carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Modeling dyskinesia in animal models of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

Motor function in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12577

21 January 2018

Identifiers

DOI

10.1111/NYAS.12577

1 reference

1 September 2017

1 reference