IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. (Q38539817)

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18 February 2020

review article

1 reference

title

IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases (English)

1 reference

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18 February 2020

0 references

Jean-Laurent Casanova

5

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18 February 2020

Andrea M. Cooper

6

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18 February 2020

Mark J. Smyth

4

1 reference

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18 February 2020

Michele W.L. Teng

1

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18 February 2020

author name string

Edward P Bowman

2

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18 February 2020

Joshua J McElwee

3

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18 February 2020

Daniel J Cua

7

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18 February 2020

language of work or name

English

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publication date

29 June 2015

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18 February 2020

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18 February 2020

volume

21

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18 February 2020

issue

7

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18 February 2020

page(s)

719-729

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https://scigraph.springernature.com/pub.10.1038/nm.3895

18 February 2020

exact match

0 references

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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

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Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

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Clinical significance of circulating interleukin-23 as a prognostic factor in breast cancer patients

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Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

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Efficacy and safety of briakinumab vs. etanercept and placebo in patients with moderate to severe chronic plaque psoriasis

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Secukinumab in plaque psoriasis--results of two phase 3 trials.

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Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

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The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases

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STATs in cancer inflammation and immunity: a leading role for STAT3

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

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Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q

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Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses

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Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency

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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

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12 December 2020

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

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12 December 2020

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

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12 December 2020

Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar Typhimurium

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12 December 2020

Interleukin-12 in anti-tumor immunity and immunotherapy.

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12 December 2020

Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

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12 December 2020

Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: a meta-analysis.

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Ustekinumab induction and maintenance therapy in refractory Crohn's disease

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Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans

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A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors

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Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

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Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

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12 December 2020

IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung

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12 December 2020

Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

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12 December 2020

Essentials of Th17 cell commitment and plasticity

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12 December 2020

Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present

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12 December 2020

Polymorphism of interleukin-23 receptor gene but not of NOD2/CARD15 is associated with graft-versus-host disease after hematopoietic stem cell transplantation in children

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12 December 2020

A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci

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12 December 2020

Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (III).

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Stat3 regulates genes common to both wound healing and cancer

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Role of IL-23 in the pathogenesis of psoriasis: a novel potential therapeutic target?

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Interleukin-12 receptor beta1 deficiency in a patient with abdominal tuberculosis

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12 December 2020

A balance of interleukin-12 and -23 in cancer

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12 December 2020

Fate mapping of IL-17-producing T cells in inflammatory responses

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Genetics of rheumatoid arthritis contributes to biology and drug discovery

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

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12 December 2020

Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells

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12 December 2020

Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice

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12 December 2020

Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells

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12 December 2020

Inherited IL-12p40 deficiency: genetic, immunologic, and clinical features of 49 patients from 30 kindreds

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12 December 2020

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).

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12 December 2020

Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis

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12 December 2020

Development, cytokine profile and function of human interleukin 17-producing helper T cells

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12 December 2020

Safety results from a pooled analysis of randomized, controlled phase II and III clinical trials and interim data from an open-label extension trial of the interleukin-12/23 monoclonal antibody, briakinumab, in moderate to severe psoriasis.

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12 December 2020

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling

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12 December 2020

Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

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12 December 2020

IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46.

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12 December 2020

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses

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12 December 2020

IL-23 is pro-proliferative, epigenetically regulated and modulated by chemotherapy in non-small cell lung cancer.

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12 December 2020

Elevated serum level of IL-23 correlates with expression of VEGF in human colorectal carcinoma.

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12 December 2020

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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12 December 2020

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

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12 December 2020

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

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12 December 2020

IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway

1 reference

12 December 2020

Genetic Variants of the IL-23R Pathway: Association with Psoriatic Arthritis and Psoriasis Vulgaris, but No Specific Risk Factor for Arthritis

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12 December 2020

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

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12 December 2020

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study

1 reference

12 December 2020

Investigation of association of the IL12B and IL23R genes with psoriatic arthritis

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12 December 2020

Tuberculosis in children and adults: two distinct genetic diseases

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12 December 2020

Interleukin 23 regulates proliferation of lung cancer cells in a concentration-dependent way in association with the interleukin-23 receptor

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12 December 2020

Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells

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12 December 2020

IL-12Rβ1 deficiency in two of fifty children with severe tuberculosis from Iran, Morocco, and Turkey

1 reference

12 December 2020

The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.

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12 December 2020

Interleukin-23 promotes the epithelial-mesenchymal transition of oesophageal carcinoma cells via the Wnt/β-catenin pathway

1 reference

12 December 2020

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

1 reference

12 December 2020

Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation

1 reference

12 December 2020

Efficacy and safety results from a phase III, randomized controlled trial comparing the safety and efficacy of briakinumab with etanercept and placebo in patients with moderate to severe chronic plaque psoriasis

1 reference

12 December 2020

Distribution and clinical significance of Th17 cells in the tumor microenvironment and peripheral blood of pancreatic cancer patients

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12 December 2020

A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis

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12 December 2020

IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available

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12 December 2020

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

1 reference

12 December 2020

Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine

1 reference

12 December 2020

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

1 reference

12 December 2020

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

1 reference

12 December 2020

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

1 reference

12 December 2020

Long-term efficacy of ustekinumab in patients with moderate-to-severe psoriasis treated for up to 5 years in the PHOENIX 1 study

1 reference

12 December 2020

Late developmental plasticity in the T helper 17 lineage

1 reference

12 December 2020

A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection

1 reference

12 December 2020

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.

1 reference

12 December 2020

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

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12 December 2020

Interpreting noncoding genetic variation in complex traits and human disease

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12 December 2020

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

1 reference

12 December 2020

Genetic dissection of immunity to mycobacteria: the human model

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12 December 2020

Genetic variations of interleukin-23R (1143A>G) and BPI (A645G), but not of NOD2, are associated with acute graft-versus-host disease after allogeneic transplantation

1 reference

12 December 2020

1 reference

12 December 2020

Opposing roles for IL-23 and IL-12 in maintaining occult cancer in an equilibrium state

1 reference

12 December 2020

Prognostic significance of genetic variants in the IL-23/Th17 pathway for the outcome of T cell-depleted allogeneic stem cell transplantation

1 reference

12 December 2020

An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis

1 reference

12 December 2020

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection

1 reference

12 December 2020

Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

1 reference

12 December 2020

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

1 reference

12 December 2020

Therapeutic opportunities of the IL-22-IL-22R1 system

1 reference

12 December 2020

A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300

1 reference

12 December 2020

A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci

1 reference

12 December 2020

Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries

1 reference

12 December 2020

Cutting edge: A critical functional role for IL-23 in psoriasis.

1 reference

12 December 2020

Immunology taught by human genetics

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12 December 2020

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

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12 December 2020

Clinical features of Candidiasis in patients with inherited interleukin 12 receptor β1 deficiency

1 reference

12 December 2020

Expression of interleukin-23 and its receptors in human squamous cell carcinoma of the oral cavity

1 reference

12 December 2020

Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression

1 reference

12 December 2020

Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis

1 reference

12 December 2020

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study

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12 December 2020

Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model

1 reference

12 December 2020

Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

1 reference

12 December 2020

Anti-IL-23 monoclonal antibody synergizes in combination with targeted therapies or IL-2 to suppress tumor growth and metastases

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12 December 2020

1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data

1 reference

12 December 2020

A phase III, randomized, controlled trial of the fully human IL-12/23 mAb briakinumab in moderate-to-severe psoriasis

1 reference

12 December 2020

The multifaceted role of Th17 lymphocytes and their associated cytokines in cancer

1 reference

12 December 2020

Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category

1 reference

12 December 2020

Anti-interleukin-12 antibody for active Crohn's disease

1 reference

12 December 2020

Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.

1 reference

12 December 2020

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans

1 reference

12 December 2020

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

1 reference

12 December 2020

Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17.

1 reference

12 December 2020

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

1 reference

12 December 2020

Suppression of lymphoma and epithelial malignancies effected by interferon gamma

1 reference

12 December 2020

Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial

1 reference

12 December 2020

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations

1 reference

12 December 2020

Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung

1 reference

12 December 2020

The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway.

1 reference

12 December 2020

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci

1 reference

12 December 2020

A phase 2, 24-week, randomized, placebo-controlled, double-blind study examining the efficacy and safety of an anti-interleukin-12 and -23 monoclonal antibody in patients with relapsing-remitting or secondary progressive multiple sclerosis

1 reference

12 December 2020

Interleukin-12 receptor beta 1 chain deficiency in a child with disseminated tuberculosis.

1 reference

12 December 2020

Clinical disease caused by Klebsiella in 2 unrelated patients with interleukin 12 receptor beta1 deficiency

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12 December 2020

IL-1RL2 and its ligands contribute to the cytokine network in psoriasis.

1 reference

12 December 2020

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

1 reference

12 December 2020

Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis

1 reference

12 December 2020

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

1 reference

12 December 2020

Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study

1 reference

12 December 2020

Does IL-17 suppress tumor growth?

1 reference

12 December 2020

Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features

1 reference

12 December 2020

Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial.

1 reference

12 December 2020

Distinct roles for interleukin-12p40 and tumour necrosis factor in resistance to oral candidiasis defined by gene-targeting.

1 reference

12 December 2020

A protective and agonistic function of IL-12p40 in mycobacterial infection.

1 reference

12 December 2020

IL-17 and IL-22: siblings, not twins.

1 reference

12 December 2020

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3895

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.3895

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26121196%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26121196%20AND%20SRC:MED&resulttype=core&format=json