Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms (Q33835683)

29 July 2017

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title

Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms (English)

1 reference

29 July 2017

0 references

Czech C

1

1 reference

PubMed ID

10670705

29 July 2017

Tremp G

series ordinal

2

1 reference

PubMed ID

10670705

29 July 2017

Pradier L

series ordinal

3

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29 July 2017

1 March 2000

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29 July 2017

Progress in Neurobiology

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29 July 2017

60

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29 July 2017

4

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29 July 2017

363-384

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beta-catenin is a target for the ubiquitin-proteasome pathway

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Identification of a novel mutation (Leu282Arg) of the human presenilin 1 gene in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Mitochondrial involvement in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Cloning and characterization of the Drosophila presenilin homologue.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Neuropathological stageing of Alzheimer-related changes

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Molecular cloning, sequencing, and brain expression of the presenilin 1 gene in Microcebus murinus

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Cloning of the presenilin 2 cDNA and its distribution in brain of the primate, Microcebus murinus: coexpression with betaAPP and Tau proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Mutations of the presenilin I gene in families with early-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

More missense in amyloid gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

The presenilin genes: a new gene family involved in Alzheimer disease pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Proteolytical processing of mutated human amyloid precursor protein in transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Gene expression of Alzheimer-associated presenilin-2 in the frontal cortex of Alzheimer and aged control brain

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Cell surface expression of the Alzheimer disease-related presenilin proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Protein topology of presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

De novo presenilin 1 mutations are rare in clinically sporadic, early onset Alzheimer's disease cases. French Alzheimer's Disease Study Group.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

A novel pathogenic mutation (Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Isolation and characterization of Drosophila presenilin homolog.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Maintenance of somite borders in mice requires the Delta homologue DII1.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

The clinical phenotype of two missense mutations in the presenilin I gene in Japanese patients.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Abeta42, presenilins, and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Mutation in codon 713 of the β amyloid precursor protein gene presenting with schizophrenia

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Familial Alzheimer's disease genes in Japanese.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Three different mutations of presenilin 1 gene in early-onset Alzheimer's disease families

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Editorial: The prevalence and malignancy of Alzheimer disease. A major killer

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Immunoreactivity of presenilin-1 in human, rat and mouse brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

A simple method for displaying the hydropathic character of a protein

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Light and electron microscopic localization of presenilin-1 in primate brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Evidence for a six-transmembrane domain structure of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Membrane topology of the C. elegans SEL-12 presenilin

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Abeta-42 deposition precedes other changes in PS-1 Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilins are processed by caspase-type proteases.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Alzheimer's disease genetics: home runs and strikeouts.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Immunohistochemical analysis of presenilin-1 expression in the mouse brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Direct association of presenilin-1 with beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Endoplasmicreticulum-induced signal transduction and gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

A repeating amino acid motif shared by proteins with diverse cellular roles

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Evidence for a physical interaction between presenilin and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

beta-Catenin--one player, two games.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Regulation of brain G-protein go by Alzheimer's disease gene presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Role of genetics in tests of genotype, status, and disease progression in early-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Regional and cellular presenilin 1 gene expression in human and rat tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Localization of Alzheimer-associated presenilin 1 in transfected COS-7 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Continuous network of endoplasmic reticulum in cerebellar Purkinje neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Cloning of Xenopus presenilin-alpha and -beta cDNAs and their differential expression in oogenesis and embryogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: double-labeling immunohistochemical study.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Identification of caspases that cleave presenilin-1 and presenilin-2

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Ueber eine im Gehirn und Rückenmark des Menschen aufgefundene Substanz mit der chemischen Reaction der Cellulose

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilin 1 binds to amyloid precursor protein directly.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Regulation of apoptosis by presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

A pedigree with a novel presenilin 1 mutation at a residue that is not conserved in presenilin 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1 reference

https://api.crossref.org/works/10.1016%2FS0301-0082%2899%2900033-7

7 January 2021

10.1016/S0301-0082(99)00033-7

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10670705