Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides (Q34750587)

4 August 2017

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title

Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides (English)

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4 August 2017

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Geneviève Evin

1

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PubMed ID

12128085

4 August 2017

Andreas Weidemann

series ordinal

2

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4 August 2017

1 July 2002

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4 August 2017

13

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inferred from page(s)

published in

Peptides

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4 August 2017

23

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4 August 2017

7

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4 August 2017

1285-1297

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Platelets and DAMI megakaryocytes possess beta-secretase-like activity.

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Regulation of APP expression, biogenesis and metabolism by extracellular matrix and cytokines.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Expression of active secreted forms of human amyloid beta-protein precursor by recombinant baculovirus-infected insect cells

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The multiple paradoxes of presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

What the evolution of the amyloid protein precursor supergene family tells us about its function

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Expression of the amyloid precursor protein of Alzheimer's disease on the surface of transfected HeLa cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Candidate gamma-secretases in the generation of the carboxyl terminus of the Alzheimer's disease beta A4 amyloid: possible involvement of cathepsin D.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Presenilin I expression in yeast lowers secretion of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Intraneuronal compartments of the amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Amyloid-beta interactions with chondroitin sulfate-derived monosaccharides and disaccharides. implications for drug development

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The beta A4 amyloid precursor protein binding to copper.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Metabolic regulation of brain Abeta by neprilysin.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Statins and the risk of dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Elevated abeta42 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of AbetaPP metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gamma-secretase products.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Cell-free assays for gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Regulation of amyloid precursor protein cleavage.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Characterization of the high affinity heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP) and its enhancement by zinc(II)

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Proteolysis of A beta peptide from Alzheimer disease brain by gelatinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Protease nexin-2/amyloid beta protein precursor. A tight-binding inhibitor of coagulation factor IXa.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The role of presenilins in gamma-secretase activity: catalyst or cofactor?

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Plaque busters: strategies to inhibit amyloid formation in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Generation of Alzheimer amyloid beta peptide through nonspecific proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end?

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

Mice deficient for the amyloid precursor protein gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0196-9781%2802%2900063-3

7 January 2021

10.1016/S0196-9781(02)00063-3

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12128085