Regulating the stability of TGFbeta receptors and Smads (Q37333694)

19 August 2017

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title

Regulating the stability of TGFbeta receptors and Smads (English)

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19 August 2017

5

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19 August 2017

Peter Lönn

1

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19 August 2017

Anita Morén

series ordinal

2

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19 August 2017

Erna Raja

series ordinal

3

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19 August 2017

Markus Dahl

series ordinal

4

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19 August 2017

1 January 2009

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19 August 2017

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19 August 2017

19

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19 August 2017

1

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19 August 2017

21-35

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https://scigraph.springernature.com/pub.10.1038/cr.2008.308

19 August 2017

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cites work

Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

New insights into TGF-beta-Smad signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Specificity and versatility in tgf-beta signaling through Smads

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Non-Smad TGF-beta signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

How the Smads regulate transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Negative regulation of TGF-beta receptor/Smad signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Transforming growth factor-beta signaling and ubiquitinators in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Ubiquitin-dependent regulation of TGFbeta signaling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Ubiquitin and ubiquitin-like proteins as multifunctional signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Protein regulation by monoubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Concepts in sumoylation: a decade on

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Role of transforming growth factor-beta superfamily signaling pathways in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Transforming growth factor beta1 induces nuclear export of inhibitory Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Critical regulation of TGFbeta signaling by Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

TGFbeta induces SIK to negatively regulate type I receptor kinase signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

The type I TGF-beta receptor is covalently modified and regulated by sumoylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome pathway to transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-beta signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Lysine conservation and context in TGFbeta and Wnt signaling suggest new targets and general themes for posttranslational modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Transforming Growth Factor-β-mediated Signaling via the p38 MAP Kinase Pathway Activates Smad-dependent Transcription through SUMO-1 Modification of Smad4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Repression of Smad4 transcriptional activity by SUMO modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Control of Smad7 stability by competition between acetylation and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

The balance between acetylation and deacetylation controls Smad7 stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Methylation of Smad6 by protein arginine N-methyltransferase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

The 26S proteasome system in the signaling pathways of TGF-beta superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

The amplified WWP1 gene is a potential molecular target in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

The Nedd4-like family of E3 ubiquitin ligases and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Oncogenic serine-threonine kinase receptor-associated protein modulates the function of Ewing sarcoma protein through a novel mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Smurf2 up-regulation activates telomere-dependent senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Dual role of SnoN in mammalian tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

7 January 2021

Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

7 January 2021

SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

7 January 2021

Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

7 January 2021

A new twist in Smad signaling

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

7 January 2021

Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

7 January 2021

Evidence for a role of Smad3 and Smad2 in stabilization of the tumor-derived mutant Smad2.Q407R

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

7 January 2021

Smad7: a new key player in TGF-beta-associated disease

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

7 January 2021

Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

7 January 2021

Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

7 January 2021

Abnormal expression of Smurf2 during the process of rat liver fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.308

7 January 2021

Identifiers

DOI

10.1038/CR.2008.308

1 reference

19 August 2017

1 reference