Enhancing the delivery of resveratrol in humans: if low bioavailability is the problem, what is the solution? (Q38262965)

1 September 2017

2 references

8 April 2021

Enhancing the delivery of resveratrol in humans: if low bioavailability is the problem, what is the solution? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270951&resulttype=core&format=json

13 May 2020

1 reference

8 April 2021

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270951&resulttype=core&format=json

13 May 2020

author name string

Otis Blanchard

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270951&resulttype=core&format=json

13 May 2020

language of work or name

English

0 references

publication date

24 October 2014

2 references

1 September 2017

8 April 2021

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270951&resulttype=core&format=json

13 May 2020

8 April 2021

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270951&resulttype=core&format=json

13 May 2020

page(s)

17154-17172

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270951&resulttype=core&format=json

13 May 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270951&resulttype=core&format=json

Creative Commons Attribution

13 May 2020

copyright license

1 reference

8 April 2021

0 references

Therapeutic potential of resveratrol: the in vivo evidence

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Aging is not programmed: genetic pseudo-program is a shadow of developmental growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol improves health and survival of mice on a high-calorie diet

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

High absorption but very low bioavailability of oral resveratrol in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Evidence for a common mechanism of SIRT1 regulation by allosteric activators

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Are sirtuins viable targets for improving healthspan and lifespan?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Metabolism and bioavailability of trans-resveratrol.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Bioavailability of trans-resveratrol from red wine in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol and health--a comprehensive review of human clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus--systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Erroneous analyses of interactions in neuroscience: a problem of significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Dose-dependent effect of resveratrol on bladder cancer cells: chemoprevention and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol exerts dosage and duration dependent effect on human mesenchymal stem cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

The bioavailability and distribution of trans-resveratrol are constrained by ABC transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Sulfation of resveratrol in human liver: evidence of a major role for the sulfotransferases SULT1A1 and SULT1E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Optimization of trans-Resveratrol bioavailability for human therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Chemistry, stability and bioavailability of resveratrol.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Administration of resveratrol: What formulation solutions to bioavailability limitations?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol metabolites do not elicit early pro-apoptotic mechanisms in neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Absorption of three wine-related polyphenols in three different matrices by healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Enhancing the bioavailability of resveratrol by combining it with piperine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol and piperine enhance radiosensitivity of tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Piperine potentiates the antidepressant-like effect of trans-resveratrol: involvement of monoaminergic system

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Prodrugs of quercetin and resveratrol: a strategy under development

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Pharmacokinetics, tissue distribution and excretion study of resveratrol and its prodrug 3,5,4'-tri-O-acetylresveratrol in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol induces acute endothelium-dependent renal vasodilation mediated through nitric oxide and reactive oxygen species scavenging

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

The effects of resveratrol on vasospasm after experimental subarachnoidal hemorrhage in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Cyclodextrin-based nanosponges for delivery of resveratrol: in vitro characterisation, stability, cytotoxicity and permeation study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: proof of concept

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Orotransmucosal drug delivery systems: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Oral mucosal drug delivery: clinical pharmacokinetics and therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Oral transmucosal etomidate in volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Pharmacokinetics of pterostilbene in Sprague-Dawley rats: the impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Novel nanocomposite stent coating releasing resveratrol and quercetin reduces neointimal hyperplasia and promotes re-endothelialization.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Characterization of trans-resveratrol-loaded lipid-core nanocapsules and tissue distribution studies in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Anticancer activity and molecular mechanism of resveratrol-bovine serum albumin nanoparticles on subcutaneously implanted human primary ovarian carcinoma cells in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum cuspidatum extract (PCE).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Recent advances of resveratrol in nanostructured based delivery systems and in the management of HIV/AIDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol: review on therapeutic potential and recent advances in drug delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Pleiotropic mechanisms facilitated by resveratrol and its metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Delipidating effect of resveratrol metabolites in 3T3-L1 adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol metabolites modify adipokine expression and secretion in 3T3-L1 pre-adipocytes and mature adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Influence of glucuronidation and reduction modifications of resveratrol on its biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Expression of sulfotransferases and sulfatases in human breast cancer: impact on resveratrol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Small-molecule allosteric activators of sirtuins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Arterial pharmacokinetics of red wine polyphenols: implications for novel endovascular therapies targeting restenosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Endothelial nitric oxide synthase in vascular disease: from marvel to menace

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Determination of quercetin and resveratrol in whole blood--implications for bioavailability studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Pharmacokinetics of trans-resveratrol following repeated administration in healthy elderly and young subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Resveratrol Is Absorbed in the Small Intestine as Resveratrol Glucuronide

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191117154

Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures

21 January 2018

1 reference

12 December 2020

Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids

1 reference

12 December 2020

Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver

1 reference

12 December 2020

Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum

1 reference

12 December 2020

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

1 reference

12 December 2020

Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention: studies in bioengineered human tissue

1 reference

12 December 2020

'Miracle stents'--a future without restenosis

1 reference

12 December 2020

Effect of food on the pharmacokinetic profile of trans-resveratrol

1 reference

12 December 2020

Essential role of ER-alpha-dependent NO production in resveratrol-mediated inhibition of restenosis.

1 reference

12 December 2020

Dose-dependent antioxidant function of resveratrol demonstrated via modulation of reactive oxygen species in normal human skin fibroblasts in vitro

1 reference

12 December 2020

Population Pharmacokinetic Modeling of trans-Resveratrol and Its Glucuronide and Sulfate Conjugates After Oral and Intravenous Administration in Rats

1 reference

12 December 2020

Challenges of translating basic research into therapeutics: resveratrol as an example

1 reference

12 December 2020

Evaluation of the Stability and Antioxidant Activity of Nanoencapsulated Resveratrol during in Vitro Digestion

1 reference

12 December 2020

Distribution of Resveratrol Metabolites in Liver, Adipose Tissue, and Skeletal Muscle in Rats Fed Different Doses of This Polyphenol

1 reference

12 December 2020

On the proper use of the crossover design in clinical trials: part 18 of a series on evaluation of scientific publications

1 reference

12 December 2020

A healthier approach to clinical trials evaluating resveratrol for primary prevention of age‐related diseases in healthy populations

1 reference

12 December 2020

Recent data do not provide evidence that resveratrol causes 'mainly negative' or 'adverse' effects on exercise training in humans

1 reference

12 December 2020

Epigenetic aging: insights from network biology

1 reference

12 December 2020

Resveratrol promotes endothelial cell wound healing under laminar shear stress through an estrogen receptor-α-dependent pathway.

1 reference

12 December 2020

Simultaneous quantification of trans-resveratrol and its sulfate and glucuronide metabolites in rat tissues by stable isotope-dilution UPLC-MS/MS analysis

1 reference

12 December 2020

Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function

1 reference

12 December 2020

Aging and DNA damage in humans: a meta‐analysis study.

1 reference

12 December 2020

Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations

1 reference

12 December 2020

10.3390/MOLECULES191117154

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270951&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270951&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6270951&resulttype=core&format=json