Mechanisms of signalling and biased agonism in G protein-coupled receptors (Q90929094)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

17 April 2020

title

Mechanisms of signalling and biased agonism in G protein-coupled receptors (English)

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17 April 2020

3

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17 April 2020

Mohan Madan Babu

4

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17 April 2020

Patrick M. Sexton

5

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17 April 2020

author name string

Denise Wootten

1

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17 April 2020

Arthur Christopoulos

2

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17 April 2020

publication date

1 October 2018

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Nature Reviews Molecular Cell Biology

17 April 2020

published in

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17 April 2020

volume

19

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17 April 2020

issue

10

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17 April 2020

page(s)

638-653

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Structured and disordered facets of the GPCR fold

17 April 2020

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Calcimimetic and calcilytic therapies for inherited disorders of the calcium-sensing receptor signalling pathway

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Convergent evidence for mGluR5 in synaptic and neuroinflammatory pathways implicated in ASD.

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7 January 2021

Recent advances in biophysical studies of rhodopsins - Oligomerization, folding, and structure.

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7 January 2021

Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes.

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7 January 2021

A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation

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7 January 2021

Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context

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7 January 2021

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.

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The dynamic process of β(2)-adrenergic receptor activation

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Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

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Priming GPCR signaling through the synergistic effect of two G proteins.

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Universal allosteric mechanism for Gα activation by GPCRs

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SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins

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5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

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Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.

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Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

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Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs.

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Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.

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7 January 2021

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Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

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7 January 2021

Structure of the human glucagon class B G-protein-coupled receptor

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7 January 2021

Extra-helical binding site of a glucagon receptor antagonist

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7 January 2021

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

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7 January 2021

Molecular basis for negative regulation of the glucagon receptor

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7 January 2021

Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

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7 January 2021

Structure of the full-length glucagon class B G-protein-coupled receptor

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7 January 2021

Structure of the glucagon receptor in complex with a glucagon analogue

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7 January 2021

Crystal structure of the GLP-1 receptor bound to a peptide agonist.

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7 January 2021

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

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7 January 2021

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

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7 January 2021

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.

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7 January 2021

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

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7 January 2021

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

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7 January 2021

Extending the Structural View of Class B GPCRs.

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7 January 2021

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.

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7 January 2021

Coexpressed Class B G Protein-Coupled Secretin and GLP-1 Receptors Self- and Cross-Associate: Impact on Pancreatic Islets.

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7 January 2021

Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation

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7 January 2021

Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation

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7 January 2021

Class C G protein-coupled receptors: reviving old couples with new partners

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7 January 2021

Structural mechanism of ligand activation in human calcium-sensing receptor.

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7 January 2021

Structural mechanism of ligand activation in human GABAB receptor

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7 January 2021

Structural biology of GABAB receptor

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7 January 2021

Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.

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7 January 2021

Molecular insights into allosteric modulation of Class C G protein-coupled receptors.

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7 January 2021

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

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7 January 2021

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

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7 January 2021

Cholecystokinin responsiveness varies across the population dependent on metabolic phenotype.

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Beneficial effects of β-sitosterol on type 1 cholecystokinin receptor dysfunction induced by elevated membrane cholesterol

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7 January 2021

Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor.

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Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid

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Newly synthesized cAMP is integrated at a membrane protein complex signalosome to ensure receptor response specificity.

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7 January 2021

Understanding the diversity of membrane lipid composition.

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7 January 2021

Caveolae as plasma membrane sensors, protectors and organizers.

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7 January 2021

Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells.

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7 January 2021

Barcoding of GPCR trafficking and signaling through the various trafficking roadmaps by compartmentalized signaling networks

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Effects of endocytosis on receptor-mediated signaling

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7 January 2021

An update on the physiological and therapeutic relevance of GPCR oligomers

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7 January 2021

Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

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7 January 2021

G Protein-Coupled Receptor Heteromers.

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7 January 2021

Assembly and architecture of the Wnt/β-catenin signalosome at the membrane.

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7 January 2021

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

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7 January 2021

Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation.

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7 January 2021

Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure

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7 January 2021

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

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7 January 2021

Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu.

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7 January 2021

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex

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7 January 2021

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

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7 January 2021

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.

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7 January 2021

Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complex

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7 January 2021

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.

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7 January 2021

Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion

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7 January 2021

Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors.

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7 January 2021

G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Endosomal generation of cAMP in GPCR signaling

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

A kinetic view of GPCR allostery and biased agonism.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Analyzing biased responses of GPCR ligands

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

The use of chemogenetic approaches to study the physiological roles of muscarinic acetylcholine receptors in the central nervous system

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

DREADDs for Neuroscientists

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

New Technologies for Elucidating Opioid Receptor Function

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Optogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuits

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Structure-based discovery of opioid analgesics with reduced side effects

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Changes in the plasma membrane in metabolic disease: impact of the membrane environment on G protein-coupled receptor structure and function

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Hypoxia sensing through β-adrenergic receptors

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Amino acid metabolites that regulate G protein signaling during osmotic stress.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Oxidation inhibits PTH receptor signaling and trafficking.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Membrane potentials regulating GPCRs: insights from experiments and molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Sodium ion binding pocket mutations and adenosine A2A receptor function.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Pharmacogenetics of the G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Biased agonism in drug discovery - is it too soon to choose a path?

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

Structural insights into G-protein-coupled receptor allostery

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

1 reference

https://api.crossref.org/works/10.1038%2FS41580-018-0049-3

7 January 2021

10.1038/S41580-018-0049-3

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30104700%20AND%20SRC:MED&resulttype=core&format=json

17 April 2020

1 reference