Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well? (Q26866054)

Laura C. Alonso

series ordinal

2

1 reference

language of work or name

1 reference

June 2014

1 reference

published in

Current diabetes report

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volume

14

1 reference

page(s)

492

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issue

6

1 reference

https://scigraph.springernature.com/pub.10.1007/s11892-014-0492-2

exact match

0 references

cites work

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The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage has impaired glucose tolerance independent of body weight

28 September 2017

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Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion

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Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity

28 September 2017

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Identification of ATP synthase as a lipid peroxide protein adduct in pancreatic islets from humans with and without type 2 diabetes mellitus

28 September 2017

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NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents

28 September 2017

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28 September 2017

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PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells

28 September 2017

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Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion

28 September 2017

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Neprilysin deficiency protects against fat-induced insulin secretory dysfunction by maintaining calcium influx

28 September 2017

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28 September 2017

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28 September 2017

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The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway

28 September 2017

1 reference

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Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate.

28 September 2017

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Overexpression of peroxisome proliferator-activated receptor α in pancreatic β-cells improves glucose tolerance in diet-induced obese mice

28 September 2017

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Pancreatic steatosis and its relationship to β-cell dysfunction in humans: racial and ethnic variations

28 September 2017

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Relationship between blood lipid profiles and pancreatic islet β cell function in Chinese men and women with normal glucose tolerance: a cross-sectional study

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in β-cell survival under endoplasmic reticulum stress: promoting ubiquitination and degradation of C/EBP homologous protein (CHOP)

28 September 2017

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Identification of direct forkhead box O1 targets involved in palmitate-induced apoptosis in clonal insulin-secreting cells using chromatin immunoprecipitation coupled to DNA selection and ligation

28 September 2017

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Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis

28 September 2017

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Statin use and the risk of incident diabetes mellitus: a review of the literature

28 September 2017

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Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling

28 September 2017

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Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction

28 September 2017

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A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death

28 September 2017

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Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines

28 September 2017

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GLP1-derived nonapeptide GLP1(28-36)amide protects pancreatic β-cells from glucolipotoxicity

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063119

HDLs protect pancreatic β-cells against ER stress by restoring protein folding and trafficking

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063119

Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18

28 September 2017

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Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis

28 September 2017

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Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass

28 September 2017

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Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes

28 September 2017

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Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice

28 September 2017

1 reference

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Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis

28 September 2017

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Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063119

UPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid

28 September 2017

1 reference

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Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids

28 September 2017

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Fatty acids suppress autophagic turnover in β-cells

28 September 2017

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Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport

28 September 2017

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Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets

28 September 2017

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Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes

28 September 2017

1 reference

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The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4063119

Glucagon-like peptide-1 and candesartan additively improve glucolipotoxicity in pancreatic β-cells

28 September 2017

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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass

28 September 2017

1 reference

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Novel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosis

28 September 2017

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Glucolipotoxicity: fuel excess and beta-cell dysfunction.

28 September 2017

1 reference

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Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.

28 September 2017

1 reference

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IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication

28 September 2017

1 reference

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Killing two birds with one stone, maybe: CETP inhibition increases both high-density lipoprotein levels and insulin secretion

28 September 2017

1 reference

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Metabolic consequences of adipose triglyceride lipase deficiency in humans: an in vivo study in patients with neutral lipid storage disease with myopathy

31 May 2018

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Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1.

31 May 2018

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G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.

31 May 2018

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Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors

31 May 2018

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Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression

31 May 2018

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The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization

31 May 2018

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Saturated free fatty acids: islet β cell "stressERs".

21 January 2018

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Susceptibility to fatty acid-induced β-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: a potential link between β-cell lipotoxicity and islet inflammation

21 January 2018

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Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1β in pancreatic rat β-cells via the IRE1α/XBP1s pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

TAK-875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β-cell dysfunction in Zucker diabetic fatty rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Multiple mechanisms of GW-9508, a selective G protein-coupled receptor 40 agonist, in the regulation of glucose homeostasis and insulin sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

β-cell metabolic alterations under chronic nutrient overload in rat and human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Quantitative imaging of electron transfer flavoprotein autofluorescence reveals the dynamics of lipid partitioning in living pancreatic islets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Changes in food intake, metabolic parameters and insulin resistance are induced by an isoenergetic, medium-chain fatty acid diet and are associated with modifications in insulin signalling in isolated rat pancreatic islets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Associations of ATP-binding cassette transporter A1 and G1 with insulin secretion in human insulinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Overexpression of glutathione peroxidase 4 prevents β-cell dysfunction induced by prolonged elevation of lipids in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Exendin-4 inhibits glucolipotoxic ER stress in pancreatic β cells via regulation of SREBP1c and C/EBPβ transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Adverse association between obesity and menopause in mice treated with bezafibrate, a pan peroxisome proliferator-activated receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Beneficial effects of lipids and prolactin on insulin secretion and beta-cell proliferation: a role for lipids in the adaptation of islets to pregnancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Higher fasting plasma free fatty acid levels are associated with lower insulin secretion in children and adults and a higher incidence of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Long-term high density lipoprotein infusion ameliorates metabolic phenotypes of diabetic db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Banting Memorial lecture 2012: reversing the twin cycles of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-014-0492-2

Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/24740729

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of pancreatic islet gene expression in mouse islets by pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24740729

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S11892-014-0492-2

1 reference

Dimensions Publication ID

1464394

1019142138

0 references

Fatcat ID

release_7ijl67r4ezemlhmzuiosctv42m

0 references

1464394

1 reference

1 reference

1 reference