DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis (Q36405094)

14 August 2017

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title

DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis (English)

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14 August 2017

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Yang Xu

1

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14 August 2017

1 April 2006

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Nature Reviews Immunology

14 August 2017

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14 August 2017

6

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14 August 2017

4

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14 August 2017

261-270

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https://scigraph.springernature.com/pub.10.1038/nri1804

14 August 2017

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cites work

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

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21 January 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

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MRE11/RAD50/NBS1: complex activities

21 January 2018

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

21 January 2018

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

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Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

21 January 2018

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

21 January 2018

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

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ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

21 January 2018

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

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DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

21 January 2018

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Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression

21 January 2018

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

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NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

21 January 2018

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Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

21 January 2018

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DNA damage-induced activation of ATM and ATM-dependent signaling pathways

21 January 2018

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

21 January 2018

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

21 January 2018

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Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

21 January 2018

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Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

21 January 2018

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The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

21 January 2018

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DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.

21 January 2018

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The role of the non-homologous end-joining pathway in lymphocyte development

21 January 2018

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The DNA-dependent protein kinase: the director at the end.

21 January 2018

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Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

21 January 2018

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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

21 January 2018

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The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps

21 January 2018

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Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair

21 January 2018

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Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu

21 January 2018

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Nonhomologous end joining and V(D)J recombination require an additional factor

21 January 2018

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Retroviral DNA integration and the DNA damage response

21 January 2018

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A role for DNA-PK in retroviral DNA integration

21 January 2018

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Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.

21 January 2018

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Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair.

21 January 2018

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Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase

21 January 2018

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Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response

21 January 2018

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DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

21 January 2018

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Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex

21 January 2018

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Deletion of the E4 region of the genome produces adenovirus DNA concatemers

21 January 2018

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Innate immune responses to infection

21 January 2018

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Roles of the NKG2D immunoreceptor and its ligands

21 January 2018

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NKG2D function protects the host from tumor initiation

21 January 2018

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The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

21 January 2018

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53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

21 January 2018

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IRF family of transcription factors as regulators of host defense

21 January 2018

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Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway

21 January 2018

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On the role of IRF in host defense

21 January 2018

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Activation of interferon regulatory factor 3 in response to DNA-damaging agents

21 January 2018

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Interferon regulatory factor-3 is an in vivo target of DNA-PK.

21 January 2018

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The mechanism and regulation of chromosomal V(D)J recombination

21 January 2018

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21 January 2018

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V(D)J recombination: how to tame a transposase

21 January 2018

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V(D)J recombination: RAG proteins, repair factors, and regulation

21 January 2018

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RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.

21 January 2018

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Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

21 January 2018

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Sensing of intermediates in V(D)J recombination by ATM.

21 January 2018

1 reference

Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

1 reference

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

21 January 2018

1 reference

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

21 January 2018

1 reference

Rescue of defective T cell development and function in Atm-/- mice by a functional TCR alpha beta transgene

21 January 2018

1 reference

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

21 January 2018

1 reference

Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response

21 January 2018

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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

21 January 2018

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The cellular response to general and programmed DNA double strand breaks

21 January 2018

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Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation

21 January 2018

1 reference

Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis

21 January 2018

1 reference

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

21 January 2018

1 reference

Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

21 January 2018

1 reference

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

21 January 2018

1 reference

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

21 January 2018

1 reference

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

21 January 2018

1 reference

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

21 January 2018

1 reference

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations.

21 January 2018

1 reference

A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

21 January 2018

1 reference

Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro

21 January 2018

1 reference

Somatic hypermutation of immunoglobulin genes

21 January 2018

1 reference

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

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Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

21 January 2018

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

21 January 2018

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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

21 January 2018

1 reference

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

21 January 2018

1 reference

The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region

21 January 2018

1 reference

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

21 January 2018

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ATM is required for efficient recombination between immunoglobulin switch regions

21 January 2018

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Immunoglobulin class switch recombination is impaired in Atm-deficient mice

21 January 2018

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53BP1, a mediator of the DNA damage checkpoint

21 January 2018

1 reference

53BP1 is required for class switch recombination

21 January 2018

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53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

21 January 2018

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H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

21 January 2018

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Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.

21 January 2018

1 reference

Nibrin functions in Ig class-switch recombination

21 January 2018

1 reference

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

21 January 2018

1 reference

Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

21 January 2018

1 reference

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

21 January 2018

1 reference

AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation

21 January 2018

1 reference

DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

21 January 2018

1 reference

The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process

21 January 2018

1 reference

Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

21 January 2018

1 reference

The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

21 January 2018

1 reference

ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region

21 January 2018

1 reference

The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions

21 January 2018

1 reference

Perforin and the granule exocytosis cytotoxicity pathway

21 January 2018

1 reference

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

21 January 2018

1 reference

Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

21 January 2018

1 reference

Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks

21 January 2018

1 reference

Cell death induced by granzyme C.

21 January 2018

1 reference

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

21 January 2018

1 reference

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

21 January 2018

1 reference

A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle

31 March 2020

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Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

31 March 2020

1 reference

ATM in lymphoid development and tumorigenesis

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRI1804

1 reference

PubMed ID

16498454

Dimensions Publication ID

14 August 2017

0 references

1 reference

PubMed ID

16498454