Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review) (Q28081170)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

review article

2 references

8 February 2021

Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review) (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json

transforming growth factor-beta.

27 February 2020

main subject

1 reference

20 November 2019

1 reference

inferred from abstract

tumor microenvironment

1 reference

8 September 2020

1 reference

14 September 2020

1 reference

13 November 2020

1 reference

8 February 2021

Panagiotis Papageorgis

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json

Triantafyllos Stylianopoulos

27 February 2020

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

author name string

Panagiotis Papageorgis

series ordinal

1

1 reference

Crossref

language of work or name

1 reference

7 January 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 March 2015

4 references

8 September 2020

14 September 2020

13 November 2020

8 February 2021

11

1 reference

International Journal of Oncology

inferred from page(s)

published in

9 references

3 April 2019

25 June 2019

20 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

8 September 2020

14 September 2020

13 November 2020

8 February 2021

46

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

issue

3

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

page(s)

933-943

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

27 February 2020

copyright license

7 references

3 April 2019

25 June 2019

20 November 2019

8 September 2020

14 September 2020

13 November 2020

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

0 references

ScienceSource

0 references

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

20 March 2017

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Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

20 March 2017

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The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

20 March 2017

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SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

20 March 2017

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TGF-beta signal transduction

20 March 2017

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Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

20 March 2017

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TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

20 March 2017

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The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition

20 March 2017

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Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta

20 March 2017

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Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

20 March 2017

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MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

20 March 2017

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20 March 2017

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

20 March 2017

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

20 March 2017

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Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

20 March 2017

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Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

20 March 2017

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

20 March 2017

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

20 March 2017

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Making sense of latent TGFbeta activation

20 March 2017

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E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

20 March 2017

1 reference

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Myofibroblasts and mechano-regulation of connective tissue remodelling

20 March 2017

1 reference

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The Smad transcriptional corepressor TGIF recruits mSin3

20 March 2017

1 reference

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The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling

20 March 2017

1 reference

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BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6

20 March 2017

1 reference

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c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

20 March 2017

1 reference

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Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines

20 March 2017

1 reference

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Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling

20 March 2017

1 reference

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Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

20 March 2017

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TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

20 March 2017

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Smad transcription factors

20 March 2017

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DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells

20 March 2017

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Smads: transcriptional activators of TGF-beta responses

20 March 2017

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Transforming growth factor beta1 induces nuclear export of inhibitory Smad7

20 March 2017

1 reference

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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

20 March 2017

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Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

20 March 2017

1 reference

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20 March 2017

1 reference

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Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

20 March 2017

1 reference

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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

20 March 2017

1 reference

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Mechanism of activation of the TGF-beta receptor

20 March 2017

1 reference

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Processing of transforming growth factor beta 1 precursor by human furin convertase

20 March 2017

1 reference

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TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA

20 March 2017

1 reference

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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

20 March 2017

1 reference

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SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling

20 March 2017

1 reference

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Thrombospondin-1 is a major activator of TGF-beta1 in vivo

20 March 2017

1 reference

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Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts

20 March 2017

1 reference

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Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells

20 March 2017

1 reference

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A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure

20 March 2017

1 reference

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The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

20 March 2017

1 reference

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EMT and dissemination precede pancreatic tumor formation

7 April 2017

1 reference

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Targeting hypoxia in cancer therapy

7 April 2017

1 reference

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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

7 April 2017

1 reference

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TGF-beta signaling in tumor suppression and cancer progression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGF-beta-induced epithelial to mesenchymal transition

7 April 2017

1 reference

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Non-Smad pathways in TGF-beta signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

7 April 2017

Cutaneous wound healing

1 reference

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The role of mechanical forces in tumor growth and therapy

7 April 2017

1 reference

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Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Combining two strategies to improve perfusion and drug delivery in solid tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Strategies for advancing cancer nanomedicine

29 September 2017

1 reference

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The roles of TGFβ in the tumour microenvironment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Tumor stromal architecture can define the intrinsic tumor response to VEGF-targeted therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Beyond TGFβ: roles of other TGFβ superfamily members in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Targeting the TGFβ signalling pathway in disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGFβ signaling plays a critical role in promoting alternative macrophage activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Mechanical compression drives cancer cells toward invasive phenotype

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Smad4 inactivation promotes malignancy and drug resistance of colon cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

A nanoparticle size series for in vivo fluorescence imaging

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Delivering nanomedicine to solid tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Dynamic interplay between the collagen scaffold and tumor evolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

The polarization of immune cells in the tumour environment by TGFbeta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Gene expression profiles in 3D tumor analogs indicate compressive strain differentially enhances metastatic potential

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Smad signaling is required to maintain epigenetic silencing during breast cancer progression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Myofibroblasts work best under stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Tranilast inhibits the growth and metastasis of mammary carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Molecular biology of bone metastasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Transforming growth factor-beta and the immune response: implications for anticancer therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGFbeta signalling in control of T-cell-mediated self-reactivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Prohibitin and cofilin are intracellular effectors of transforming growth factor beta signaling in human prostate cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Epithelial-mesenchymal transitions: twist in development and metastasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

The two faces of transforming growth factor beta in carcinogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGF-beta signaling: positive and negative effects on tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

29 September 2017

TGF-beta and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-beta receptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGFbeta regulation of mitogen-activated protein kinases in human breast cancer cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Frequency of Smad gene mutations in human cancers.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Role of transforming growth factor-beta in tissue injury and repair

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Differentiation plasticity regulated by TGF-beta family proteins in development and disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

The involvement of p38 MAPK in transforming growth factor beta1-induced apoptosis in murine hepatocytes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Latent TGF-beta binding protein LTBP-1 contains three potential extracellular matrix interacting domains.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306018

Phase I trial of gemcitabine and candesartan combination therapy in normotensive patients with advanced pancreatic cancer: GECA1

27 November 2018

1 reference

12 December 2020

The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta

1 reference

12 December 2020

Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma

1 reference

12 December 2020

Transforming growth factor-beta1 induces apoptosis in vascular endothelial cells by activation of mitogen-activated protein kinase

1 reference

12 December 2020

Integration of Smad and MAPK pathways: a link and a linker revisited

1 reference

12 December 2020

Normal embryo fibroblasts release transforming growth factors in a latent form

1 reference

12 December 2020

Impact of angiotensin I converting enzyme inhibitors and angiotensin II type 1 receptor blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapy

1 reference

12 December 2020

Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells

1 reference

12 December 2020

Homozygous deletion map at 18q21.1 in pancreatic cancer

1 reference

12 December 2020

DPC4 gene in various tumor types

1 reference

12 December 2020

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1 reference

12 December 2020

Contrasting effects of TGF-beta 1 and TNF-alpha on the development of dendritic cells from progenitors in mouse bone marrow

1 reference

12 December 2020

Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation

1 reference

12 December 2020

Identifiers

DOI

10.3892/IJO.2015.2816

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

PubMed publication ID

25573346

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25573346%20AND%20SRC:MED&resulttype=core&format=json