Genetic modelling of the PTEN/AKT pathway in cancer research (Q37305035)

19 August 2017

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title

Genetic modelling of the PTEN/AKT pathway in cancer research (English)

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19 August 2017

Oliver Renner

1

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Carmen Blanco-Aparicio

object named as

Carmen Blanco-Aparicio

series ordinal

2

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Amancio Carnero

object named as

Amancio Carnero

series ordinal

3

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publication date

1 October 2008

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Clinical and Translational Oncology

19 August 2017

published in

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19 August 2017

volume

10

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19 August 2017

issue

10

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19 August 2017

page(s)

618-627

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https://scigraph.springernature.com/pub.10.1007/s12094-008-0262-1

19 August 2017

exact match

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cites work

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

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https://api.crossref.org/works/10.1007%2FS12094-008-0262-1

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-008-0262-1

Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-008-0262-1

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-008-0262-1

Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-008-0262-1

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12094-008-0262-1

Oncogenic PI3K and its role in cancer

21 January 2018

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12 December 2020

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

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12 December 2020

Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice

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12 December 2020

Gatekeeper for endometrium: the PTEN tumor suppressor gene

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12 December 2020

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice

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12 December 2020

Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion

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12 December 2020

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

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12 December 2020

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

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12 December 2020

T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus

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12 December 2020

Mammary ductal and alveolar development: lesson learned from genetically manipulated mice

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12 December 2020

PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

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12 December 2020

Pten is essential for embryonic development and tumour suppression

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12 December 2020

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

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12 December 2020

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

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12 December 2020

Phosphoinositide 3-kinases and the regulation of vesicular trafficking

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12 December 2020

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

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12 December 2020

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

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12 December 2020

Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase

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12 December 2020

Pten haploinsufficiency accelerates formation of high-grade astrocytomas

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12 December 2020

Oncogenic mutations of PIK3CA in human cancers

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12 December 2020

Signalling by PI3K isoforms: insights from gene-targeted mice.

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12 December 2020

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

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12 December 2020

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

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12 December 2020

PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways

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12 December 2020

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

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12 December 2020

PTEN-deficient intestinal stem cells initiate intestinal polyposis

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12 December 2020

High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice

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12 December 2020

Class 1A PI3K regulates vessel integrity during development and tumorigenesis

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12 December 2020

Mouse modeling in oncologic preclinical and translational research

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12 December 2020

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

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12 December 2020

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

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12 December 2020

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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12 December 2020

Synthesis and function of 3-phosphorylated inositol lipids

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12 December 2020

Cancer-specific mutations in PIK3CA are oncogenic in vivo

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12 December 2020

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

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12 December 2020

Essential role of PDK1 in regulating cell size and development in mice

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12 December 2020

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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12 December 2020

PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.

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12 December 2020

Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.

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12 December 2020

PIK3CA is implicated as an oncogene in ovarian cancer.

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12 December 2020

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

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12 December 2020

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

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12 December 2020

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling

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12 December 2020

Knockout mouse models and mammary tumorigenesis

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12 December 2020

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

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12 December 2020

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

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12 December 2020

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

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12 December 2020

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

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12 December 2020

PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

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12 December 2020

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

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12 December 2020

Membrane localization of all class I PI 3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fibroblasts via Akt.

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12 December 2020

PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways

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12 December 2020

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

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12 December 2020

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

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12 December 2020

Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis

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12 December 2020

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

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12 December 2020

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12 December 2020

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

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12 December 2020

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

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12 December 2020

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.

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12 December 2020

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

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12 December 2020

Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production

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12 December 2020

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

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12 December 2020

Cellular survival: a play in three Akts

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12 December 2020

Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice

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12 December 2020

Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland

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12 December 2020

Rare cancer-specific mutations in PIK3CA show gain of function

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12 December 2020

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

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12 December 2020

The PTEN-PI3K pathway: of feedbacks and cross-talks

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12 December 2020

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

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12 December 2020

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

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12 December 2020

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

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12 December 2020

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

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12 December 2020

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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12 December 2020

Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor

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12 December 2020

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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12 December 2020

Physiological functions of Pten in mouse tissues

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12 December 2020

Direct control of the Forkhead transcription factor AFX by protein kinase B

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12 December 2020

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

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12 December 2020

Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit

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12 December 2020

Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer

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12 December 2020

Clinical and pathological features of breast disease in Cowden's syndrome: an underrecognized syndrome with an increased risk of breast cancer

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12 December 2020

Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice

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12 December 2020

Characterization of the p53 response to oncogene-induced senescence

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12 December 2020

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

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12 December 2020

Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas.

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12 December 2020

Colorectal cancer: mutations in a signalling pathway

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12 December 2020

The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey

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12 December 2020

High frequency of mutations of the PIK3CA gene in human cancers

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12 December 2020

The akt kinase: molecular determinants of oncogenicity

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12 December 2020

A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells

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12 December 2020

Targeting RAS signalling pathways in cancer therapy

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12 December 2020

Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer

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12 December 2020

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

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12 December 2020

Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling

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12 December 2020

Human cancer, PTEN and the PI-3 kinase pathway

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12 December 2020

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

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12 December 2020

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

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12 December 2020

p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control

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12 December 2020

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

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12 December 2020

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

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12 December 2020

Delayed mammary gland involution in MMTV-AKT1 transgenic mice

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12 December 2020

PTEN, more than the AKT pathway

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12 December 2020

Akt signaling and cancer: surviving but not moving on.

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12 December 2020

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

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12 December 2020

PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry

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12 December 2020

Phosphoinositide 3-kinases: a conserved family of signal transducers

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12 December 2020

Akt1 governs breast cancer progression in vivo

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12 December 2020

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas

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12 December 2020

Stem cells, cancer, and cancer stem cells

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12 December 2020

Phosphoinositide kinases

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12 December 2020

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

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12 December 2020

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

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12 December 2020

Mammary gland involution is delayed by activated Akt in transgenic mice.

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12 December 2020

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

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12 December 2020

A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression

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12 December 2020

Class I PI3K in oncogenic cellular transformation.

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12 December 2020

Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation

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12 December 2020

Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.

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12 December 2020

Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.

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12 December 2020

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

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12 December 2020

Genetic background controls tumor development in PTEN-deficient mice.

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12 December 2020

The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas

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12 December 2020

Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

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12 December 2020

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

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12 December 2020

The phosphoinositide 3-kinase pathway

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12 December 2020

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

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12 December 2020

Regulation of p53: intricate loops and delicate balances

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12 December 2020

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation

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12 December 2020

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

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12 December 2020

Functional analysis of PIK3CA gene mutations in human colorectal cancer

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12 December 2020

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate

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12 December 2020

Ten years of protein kinase B signalling: a hard Akt to follow

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12 December 2020

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

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12 December 2020

Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth

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12 December 2020

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

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12 December 2020

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

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12 December 2020

Akt1 in osteoblasts and osteoclasts controls bone remodeling

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12 December 2020

BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance.

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12 December 2020

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis

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12 December 2020

Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils

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12 December 2020

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

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12 December 2020

Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

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12 December 2020

p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity

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12 December 2020

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

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12 December 2020

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

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12 December 2020

Akt/protein kinase B promotes organ growth in transgenic mice

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12 December 2020

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

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12 December 2020

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

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12 December 2020

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

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12 December 2020

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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12 December 2020

RETRACTED: Regulation of p53: intricate loops and delicate balances

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3 January 2024

https://opencitations.net/index/api/v1/citations/10.1016/S0006-2952(02)01149-8

Identifiers

DOI

10.1007/S12094-008-0262-1

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19 August 2017

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