The expanding universe of p53 targets (Q37602507)

21 August 2017

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title

The expanding universe of p53 targets (English)

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21 August 2017

Daniel Menendez

1

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21 August 2017

Alberto Inga

series ordinal

2

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21 August 2017

Michael A Resnick

series ordinal

3

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21 August 2017

language of work or name

English

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publication date

1 October 2009

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21 August 2017

Nature Reviews Cancer

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21 August 2017

9

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21 August 2017

10

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21 August 2017

724-737

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https://scigraph.springernature.com/pub.10.1038/nrc2730

21 August 2017

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cites work

Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression

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p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints.

31 March 2020

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MicroRNA-125b is a novel negative regulator of p53.

31 March 2020

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Polypyrimidine tract binding protein regulates IRES-mediated translation of p53 isoforms.

31 March 2020

1 reference

Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.

31 March 2020

1 reference

Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26

31 March 2020

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P53 mRNA controls p53 activity by managing Mdm2 functions

31 March 2020

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Negative feedback regulation of wild-type p53 biosynthesis.

31 March 2020

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Post-translational modification of p53 in tumorigenesis

31 March 2020

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p53 regulates maternal reproduction through LIF

31 March 2020

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p53 modulation of the DNA damage response

31 March 2020

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Transcriptional control of human p53-regulated genes

31 March 2020

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Blinded by the Light: The Growing Complexity of p53

31 March 2020

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Outcomes of p53 activation--spoilt for choice

31 March 2020

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

31 March 2020

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Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis.

31 March 2020

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p53 regulates mitochondrial respiration

31 March 2020

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p53 and metabolism: Inside the TIGAR.

31 March 2020

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p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase

31 March 2020

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A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network

31 March 2020

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p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines

31 March 2020

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Control of cell migration: a tumour suppressor function for p53?

31 March 2020

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p53 target gene SMAR1 is dysregulated in breast cancer: its role in cancer cell migration and invasion

31 March 2020

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A novel function for p53: regulation of growth cone motility through interaction with Rho kinase

31 March 2020

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p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner

31 March 2020

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The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon

31 March 2020

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The regulation of exosome secretion: a novel function of the p53 protein

31 March 2020

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microRNAs join the p53 network--another piece in the tumour-suppression puzzle

31 March 2020

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p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest

31 March 2020

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Dissecting microregulation of a master regulatory network

31 March 2020

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miR-34a repression of SIRT1 regulates apoptosis

31 March 2020

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When mutants gain new powers: news from the mutant p53 field.

31 March 2020

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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

31 March 2020

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The oncogenic roles of p53 mutants in mouse models

31 March 2020

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Modeling the therapeutic efficacy of p53 restoration in tumors

31 March 2020

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Crippling p53 activities via knock-in mutations in mouse models

31 March 2020

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High metastatic potential in mice inheriting a targeted p53 missense mutation

31 March 2020

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Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

31 March 2020

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Transcriptional functionality of germ line p53 mutants influences cancer phenotype.

31 March 2020

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TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

31 March 2020

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Definition of a consensus binding site for p53

31 March 2020

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A transcriptionally active DNA-binding site for human p53 protein complexes

31 March 2020

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Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.

31 March 2020

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Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

31 March 2020

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Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor.

31 March 2020

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Live or let die: the cell's response to p53

31 March 2020

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Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

31 March 2020

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A global map of p53 transcription-factor binding sites in the human genome

31 March 2020

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Mdm2 promotes the rapid degradation of p53

31 March 2020

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p53 ubiquitination: Mdm2 and beyond

31 March 2020

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P53 promoter selection: choosing between life and death

31 March 2020

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Mechanisms of regulatory diversity within the p53 transcriptional network

31 March 2020

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A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation

31 March 2020

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MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription

31 March 2020

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SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription

31 March 2020

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Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53

31 March 2020

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Recruitment of p300/CBP in p53-dependent signal pathways

31 March 2020

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p300/CBP/p53 interaction and regulation of the p53 response

31 March 2020

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Binding and modulation of p53 by p300/CBP coactivators

31 March 2020

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Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes

31 March 2020

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Histone modifications in transcriptional regulation

31 March 2020

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Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators

31 March 2020

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The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

31 March 2020

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iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

31 March 2020

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ASPP proteins specifically stimulate the apoptotic function of p53

31 March 2020

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hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes

31 March 2020

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A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis

31 March 2020

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Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

31 March 2020

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

31 March 2020

2 references

31 March 2020

12 December 2020

p53 isoforms can regulate p53 transcriptional activity.

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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

31 March 2020

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Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

31 March 2020

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Y-box factor YB1 controls p53 apoptotic function

31 March 2020

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Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response

31 March 2020

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Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

31 March 2020

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Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate.

31 March 2020

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

31 March 2020

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p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

31 March 2020

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Chromatin immunoprecipitation-based screen to identify functional genomic binding sites for sequence-specific transactivators

31 March 2020

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Kinetics of p53 binding to promoter sites in vivo

31 March 2020

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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

31 March 2020

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Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

31 March 2020

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p53 function and dysfunction

31 March 2020

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Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains

31 March 2020

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Structure of the p53 core domain dimer bound to DNA.

31 March 2020

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Structural basis of DNA recognition by p53 tetramers.

31 March 2020

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Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex

31 March 2020

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p53 domains: identification and characterization of two autonomous DNA-binding regions.

31 March 2020

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Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain

31 March 2020

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The versatile interactions of p53 with DNA: when flexibility serves specificity

31 March 2020

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Interactions of mutant p53 with DNA: guilt by association

31 March 2020

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Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

31 March 2020

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Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.

31 March 2020

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Structural biology of the p53 tumour suppressor

31 March 2020

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Structural biology of the tumor suppressor p53.

31 March 2020

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Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.

31 March 2020

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A polymorphic microsatellite that mediates induction of PIG3 by p53.

31 March 2020

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Divergent evolution of human p53 binding sites: cell cycle versus apoptosis

31 March 2020

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Functional evolution of the p53 regulatory network through its target response elements

31 March 2020

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Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity

31 March 2020

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Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.

31 March 2020

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p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines

31 March 2020

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Comparative binding of p53 to its promoter and DNA recognition elements.

31 March 2020

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Mutation of conserved domain II alters the sequence specificity of DNA binding by the p53 protein.

31 March 2020

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Noncanonical DNA motifs as transactivation targets by wild type and mutant p53

31 March 2020

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DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53.

31 March 2020

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Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

31 March 2020

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Acetylation of the p53 DNA-binding domain regulates apoptosis induction

31 March 2020

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Chromatin immunoprecipitation-on-chip reveals stress-dependent p53 occupancy in primary normal cells but not in established cell lines.

31 March 2020

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Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts

31 March 2020

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Transcriptional repression mediated by the p53 tumour suppressor

31 March 2020

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Repression of CDK1 and other genes with CDE and CHR promoter elements during DNA damage-induced G(2)/M arrest in human cells

31 March 2020

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Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction.

31 March 2020

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Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

31 March 2020

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Repression of RNA polymerase I transcription by the tumor suppressor p53

31 March 2020

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Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

31 March 2020

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p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest

31 March 2020

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p53 represses c-Myc through induction of the tumor suppressor miR-145

31 March 2020

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Transcriptional repression by p53 through direct binding to a novel DNA element

31 March 2020

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

31 March 2020

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LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma

31 March 2020

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Redefining the p53 response element

31 March 2020

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p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor

31 March 2020

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Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1

31 March 2020

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Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage

31 March 2020

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Transcriptional repression of protein kinase Calpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation

31 March 2020

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Role of protein kinase C and the Sp1-p53 complex in activation of p21(WAF-1) expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells

31 March 2020

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p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter

31 March 2020

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p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcription

31 March 2020

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p73 is a p53-independent, Sp1-dependent repressor of cyclin B1 transcription.

31 March 2020

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The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism

31 March 2020

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Characterization of genome-wide p53-binding sites upon stress response.

31 March 2020

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An integrated map of p53-binding sites and histone modification in the human ENCODE regions

31 March 2020

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A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage.

31 March 2020

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How p53 binds DNA as a tetramer

31 March 2020

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Role of tumor suppressor p53 domains in selective binding to supercoiled DNA.

31 March 2020

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Mechanistic insights into maintenance of high p53 acetylation by PTEN.

31 March 2020

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Functional four-base A/T gap core sequence CATTAG of P53 response elements specifically bound tetrameric P53 differently than two-base A/T gap core sequence CATG bound both dimeric and tetrameric P53

31 March 2020

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

31 March 2020

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Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors

31 March 2020

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Role of NF-κB in p53-mediated programmed cell death

31 March 2020

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Transcriptional cross talk between NF-kappaB and p53.

31 March 2020

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A balance between NF-Y and p53 governs the pro- and anti-apoptotic transcriptional response.

31 March 2020

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Upregulation of annexin A1 expression by butyrate in human colon adenocarcinoma cells: role of p53, NF-Y, and p38 mitogen-activated protein kinase.

31 March 2020

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Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y.

31 March 2020

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Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53

31 March 2020

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Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

31 March 2020

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Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function

31 March 2020

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Contribution of estrogen receptor alpha to oncogenic K-Ras-mediated NIH3T3 cell transformation and its implication for escape from senescence by modulating the p53 pathway.

31 March 2020

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Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads.

31 March 2020

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Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression

31 March 2020

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p53 leans on its siblings

31 March 2020

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p63 consensus DNA-binding site: identification, analysis and application into a p63MH algorithm.

31 March 2020

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p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.

31 March 2020

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A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

31 March 2020

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MDM2 SNP309 accelerates colorectal tumour formation in women.

31 March 2020

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A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1.

31 March 2020

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The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells

31 March 2020

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Regulation and function of the p53 tumor suppressor protein

31 March 2020

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Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression

31 March 2020

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Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

31 March 2020

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Transcription regulation by mutant p53.

31 March 2020

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Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

31 March 2020

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A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

31 March 2020

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p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

31 March 2020

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

31 March 2020

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An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma

31 March 2020

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Increased apoptosis induction by 121F mutant p53

31 March 2020

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The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes

31 March 2020

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The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

31 March 2020

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Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study.

31 March 2020

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Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation

31 March 2020

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p53--a key player in tumoral and evolutionary adaptation: a lesson from the Israeli blind subterranean mole rat.

31 March 2020

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

31 March 2020

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

31 March 2020

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

31 March 2020

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Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

31 March 2020

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Functional analysis of p53 binding under differential stresses

31 March 2020

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Mammalian p53 can function as a transcription factor in yeast

31 March 2020

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Screening patients for heterozygous p53 mutations using a functional assay in yeast

31 March 2020

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Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson

31 March 2020

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WebLogo: A Sequence Logo Generator

31 March 2020

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Mouse models with modified p53 sequences to study cancer and ageing.

31 March 2020

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p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice.

31 March 2020

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Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53.

31 March 2020

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Functional characterization of global genomic DNA repair and its implications for cancer.

31 March 2020

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MDM2 and MDM4: p53 regulators as targets in anticancer therapy

31 March 2020

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Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation

31 March 2020

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

31 March 2020

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

31 March 2020

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E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.

31 March 2020

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31 March 2020

Why is p53 acetylated?

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RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells.

31 March 2020

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Differential recognition of response elements determines target gene specificity for p53 and p63

31 March 2020

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Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

31 March 2020

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12 December 2020

Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma

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12 December 2020

CA/TG sequence at the 5' end of oligo(A)-tracts strongly modulates DNA curvature

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12 December 2020

TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution.

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12 December 2020

Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression

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12 December 2020

Estrogen receptor protects p53 from deactivation by human double minute-2

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12 December 2020

A promoter that acquired p53 responsiveness during primate evolution

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12 December 2020

PAX4 has the potential to function as a tumor suppressor in human melanoma.

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12 December 2020

Identifiers

DOI

10.1038/NRC2730

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Dimensions Publication ID

21 August 2017

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