Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer. (Q38936250)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27557534%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

review article

1 reference

title

Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27557534%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27557534%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Costas A Lyssiotis

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27557534%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

author name string

Lewis C Cantley

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27557534%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

publication date

1 January 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27557534%20AND%20SRC:MED&resulttype=core&format=json

Recent Results in Cancer Research

21 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27557534%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

volume

207

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27557534%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

page(s)

39-72

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27557534%20AND%20SRC:MED&resulttype=core&format=json

Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines.

21 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Sequence analysis of mutations and translocations across breast cancer subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Regulation of mTORC1 by amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Hypoxia-inducible factor-1 and oncogenic signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

ATP citrate lyase is an important component of cell growth and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Activation of AKT kinases in cancer: implications for therapeutic targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

18F-FDG PET and PET/CT in the evaluation of cancer treatment response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

E17K substitution in AKT1 in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Genistein inhibits nonoxidative ribose synthesis in MIA pancreatic adenocarcinoma cells: a new mechanism of controlling tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Hypoxia signalling controls metabolic demand

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Targeting Akt3 signaling in triple-negative breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

A novel AKT3 mutation in melanoma tumours and cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

SUMOylation regulates AKT1 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Hypoxia, HIF1 and glucose metabolism in the solid tumour

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Akt stimulates aerobic glycolysis in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Regulation of sterol synthesis in eukaryotes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Idelalisib--a PI3Kδ inhibitor for B-cell cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

PI3K and cancer: lessons, challenges and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Glutamine and cancer: cell biology, physiology, and clinical opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The GLUT4 glucose transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Subcellular localization of hexokinases I and II directs the metabolic fate of glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1/SREBP1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Molecular Pathways: Targeting MYC-induced metabolic reprogramming and oncogenic stress in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Akt SUMOylation regulates cell proliferation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Molecular mechanisms of mTOR-mediated translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

PIK3CA as an oncogene in cervical cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

AKT/PKB signaling: navigating downstream

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Energy metabolism in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

TXNIP regulates peripheral glucose metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Colorectal cancer: mutations in a signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Antagonism between FOXO and MYC Regulates Cellular Powerhouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Expression analysis of genes at 3q26-q27 involved in frequent amplification in squamous cell lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The phosphogluconate pathway and synthesis of 5-phosphoribosyl-1-pyrophosphate in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Development of PI3K inhibitors: lessons learned from early clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

PIKfyve: Partners, significance, debates and paradoxes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The landscape of cancer genes and mutational processes in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Phosphoinositide 3-kinases-a historical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Signalling through the lipid products of phosphoinositide-3-OH kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Signaling by distinct classes of phosphoinositide 3-kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

On the Origin of Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Insulin-like growth factor-I stimulates amino acid transport in a glutamine-deprived human neuroblastoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The Warburg hypothesis fifty years later

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

The E3 ligase TRAF6 regulates Akt ubiquitination and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Mutation of the PIK3CA gene in ovarian and breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Hexose monophosphate shunt enzymes in lung tumors from normal and glucose-6-phosphate-dehydrogenase-deficient subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Promoter methylation of the PTEN gene is a common molecular change in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Hormonal regulation of amino acid transport system N in primary cultures of rat hepatocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Responses of glutamine transport in cultured rat skeletal muscle to osmotically induced changes in cell volume

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylat

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Glucose-6-phosphate dehydrogenase: a possible clinical indicator for prostatic carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-42118-6_3

10.1007/978-3-319-42118-6_3

31 March 2020

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27557534%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference