Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation. (Q36089357)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15810902%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

review article

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title

Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15810902%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

0 references

1

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10 January 2020

author name string

Robakis NK

series ordinal

2

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10 January 2020

language of work or name

English

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publication date

1 April 2005

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Genes, Brain and Behavior

10 January 2020

published in

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10 January 2020

volume

4

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10 January 2020

issue

3

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10 January 2020

page(s)

134-146

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Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology

10 January 2020

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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TCF transcription factors: molecular switches in carcinogenesis

21 January 2018

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Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

21 January 2018

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

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Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

21 January 2018

1 reference

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The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

21 January 2018

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Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

21 January 2018

1 reference

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Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Molecular genetics of Alzheimer's disease.

21 January 2018

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Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

21 January 2018

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Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

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Localization of Alzheimer-associated presenilin 1 in transfected COS-7 cells.

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1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

New frontiers in Alzheimer's disease genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Cadherins in embryonic and neural morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Some morphometric aspects of the brain in senile dementia of the alzheimer type

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Distinct presenilin‐dependent and presenilin‐independent γ‐secretases are responsible for total cellular Aβ production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

c-fos protein-like immunoreactivity: distribution in the human brain and over-expression in the hippocampus of patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-183X.2005.00086.X

10.1111/J.1601-183X.2005.00086.X

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15810902%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference