Sirtuin 1 (SIRT1): the misunderstood HDAC. (Q37956584)

25 August 2017

title

Sirtuin 1 (SIRT1): the misunderstood HDAC. (English)

1 reference

25 August 2017

Walter Stünkel

1

1 reference

25 August 2017

Robert M Campbell

series ordinal

2

1 reference

25 August 2017

language of work or name

1 reference

15 November 2011

1 reference

Journal of Biomolecular Screening

25 August 2017

published in

1 reference

25 August 2017

volume

16

1 reference

25 August 2017

issue

10

1 reference

25 August 2017

page(s)

1153-1169

1 reference

Cellular and molecular effects of sirtuins in health and disease.

25 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Advances in characterization of human sirtuin isoforms: chemistries, targets and therapeutic applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Mammalian sirtuins: biological insights and disease relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Fluorescence in situ hybridization and chromosomal organization of the sirtuin 4 gene (Sirt4) in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Sirtuins: critical regulators at the crossroads between cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Histone H4 lysine 16 acetylation regulates cellular lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Mammalian SIRT1 represses forkhead transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

FoxO1 mediates an autofeedback loop regulating SIRT1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

PTEN acetylation modulates its interaction with PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 promotes DNA repair activity and deacetylation of Ku70

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Acetylation of tau inhibits its degradation and contributes to tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 deacetylates APE1 and regulates cellular base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 regulates HIV transcription via Tat deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Sirtuins: a conserved key unlocking AceCS activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 is regulated by a PPAR{γ}-SIRT1 negative feedback loop associated with senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Hormonal control of androgen receptor function through SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 deacetylates and positively regulates the nuclear receptor LXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 shows no substrate specificity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Roles of FoxO1 and Sirt1 in the central regulation of food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Mammalian circadian clock and metabolism - the epigenetic link

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 and endocrine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Roles of SIRT1 in the acute and restorative phases following induction of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Expression and prognostic significance of SIRT1 in ovarian epithelial tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SirT1 is an inhibitor of proliferation and tumor formation in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1: recent lessons from mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

A functional link between SIRT1 deacetylase and NBS1 in DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 negatively regulates the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Targeting the Akt/mTOR pathway in Brca1-deficient cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

The β-catenin/Tcf4/survivin signaling maintains a less differentiated phenotype and high proliferative capacity of human corneal epithelial progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

A c-Myc-SIRT1 feedback loop regulates cell growth and transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Tip60: connecting chromatin to DNA damage signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 controls endothelial angiogenic functions during vascular growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Improved fluorogenic histone deacetylase assay for high-throughput-screening applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Advances in label-free screening approaches for studying histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Identification of a small molecule inhibitor of Sir2p

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Quantitative assays for characterization of the Sir2 family of NAD(+)-dependent deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1 stimulation by polyphenols is affected by their stability and metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Mechanism of human SIRT1 activation by resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Substrate-specific activation of sirtuins by resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Inhibition of ATPase activity of Escherichia coli ATP synthase by polyphenols

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Identification of new p53 acetylation sites in COS-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Identification and characterization of novel sirtuin inhibitor scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Structure and autoregulation of the yeast Hst2 homolog of Sir2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Crystal structure of a SIR2 homolog-NAD complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Structural basis for the NAD-dependent deacetylase mechanism of Sir2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Structure of a Sir2 enzyme bound to an acetylated p53 peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Sirtuins--novel therapeutic targets to treat age-associated diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Structure of the histone deacetylase SIRT2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Crystal structures of human SIRT3 displaying substrate-induced conformational changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Inhibitors of Sir2: evaluation of splitomicin analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD+ and Acetylated Peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

The Structural Basis of Sirtuin Substrate Affinity†,‡

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins)

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057111422103

21 January 2018

Identifiers

DOI

10.1177/1087057111422103

1 reference

25 August 2017

1 reference