Ubiquitination involved enzymes and cancer (Q38229325)

31 August 2017

title

Ubiquitination involved enzymes and cancer (English)

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31 August 2017

main subject

protein ubiquitination

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Mei-juan Zhou

1

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31 August 2017

Fang-zhi Chen

series ordinal

2

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31 August 2017

Han-chun Chen

series ordinal

3

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31 August 2017

publication date

15 July 2014

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31 August 2017

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31 August 2017

volume

31

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31 August 2017

issue

8

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31 August 2017

page(s)

93

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Ubiquitin: structures, functions, mechanisms

31 August 2017

cites work

1 reference

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21 January 2018

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Back to the future with ubiquitin

21 January 2018

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Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease

21 January 2018

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Protein ubiquitylation in pancreatic cancer.

21 January 2018

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Ubiquitin-dependent proteolysis: its role in human diseases and the design of therapeutic strategies

21 January 2018

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Therapeutic anti-cancer targets upstream of the proteasome.

21 January 2018

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Polyubiquitin chains: polymeric protein signals

21 January 2018

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Mechanisms underlying ubiquitination

21 January 2018

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A field guide to ubiquitylation

21 January 2018

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RING domain E3 ubiquitin ligases

21 January 2018

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A bimolecular affinity purification method under denaturing conditions for rapid isolation of a ubiquitinated protein for mass spectrometry analysis.

21 January 2018

1 reference

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Narrative review: protein degradation and human diseases: the ubiquitin connection

21 January 2018

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Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

UBE1L2, a novel E1 enzyme specific for ubiquitin

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

In vitro assembly and recognition of Lys-63 polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Anatomy of the E2 ligase fold: implications for enzymology and evolution of ubiquitin/Ub-like protein conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

The ubiquitin-conjugating enzyme E2-EPF is overexpressed in primary breast cancer and modulates sensitivity to topoisomerase II inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Rad6B is a positive regulator of beta-catenin stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Wnt signaling in breast cancer: have we come full circle?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Drug discovery in the ubiquitin-proteasome system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Physiological functions of the HECT family of ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

New targeted approaches against the ubiquitin-proteasome system in gastrointestinal malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

E3 ubiquitin ligases as cancer targets and biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

A census of human cancer genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Radiosensitization of Cancer Cells by Inactivation of Cullin-RING E3 Ubiquitin Ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

SCF and Cullin/Ring H2-based ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Regulation of Skp2 expression and activity and its role in cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

The SCF ubiquitin ligase: insights into a molecular machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Mechanisms of tumor suppression by the SCF(Fbw7).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Cell cycle regulatory E3 ubiquitin ligases as anticancer targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Regulating the p53 system through ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Shaping genetic alterations in human cancer: the p53 mutation paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Ubiquitination regulates PTEN nuclear import and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

A central role for the ring finger protein RNF11 in ubiquitin-mediated proteolysis via interactions with E2s and E3s.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Signal transduction by the TGF-beta superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Overexpression of WWP1 is associated with the estrogen receptor and insulin-like growth factor receptor 1 in breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Role of VHL gene mutation in human renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

von Hippel-Lindau disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Targeting the ubiquitin system in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

The contribution of BRCA1 and BRCA2 to ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

The ubiquitin E3 ligase activity of BRCA1 and its biological functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Targeting the ubiquitin-proteasome system for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Modification of proteins by ubiquitin and ubiquitin-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS12032-014-0093-6

21 January 2018

12 December 2020

UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme

1 reference

12 December 2020

Targeting E3 ubiquitin ligases for cancer therapy.

1 reference

12 December 2020

Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue

1 reference

12 December 2020

Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer

1 reference

12 December 2020

Ubiquitin-mediated protein degradation.

1 reference

12 December 2020

High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma

1 reference

12 December 2020

The ubiquitin-proteasomal system is critical for multiple myeloma: implications in drug discovery

1 reference

12 December 2020

Emerging roles for Lys11-linked polyubiquitin in cellular regulation.

1 reference

12 December 2020

Pathways of ubiquitin conjugation.

1 reference

12 December 2020

The protein substrate binding site of the ubiquitin-protein ligase system.

1 reference

12 December 2020

10.1007/S12032-014-0093-6

Identifiers

DOI

1 reference

Dimensions Publication ID

31 August 2017

1051757490

0 references

1 reference