A simple matter of life and death-the trials of postnatal Beta-cell mass regulation (Q35942505)

11 August 2017

A simple matter of life and death-the trials of postnatal Beta-cell mass regulation (English)

1 reference

11 August 2017

Elena Tarabra

1

1 reference

PMCID

3346985

11 August 2017

Stella Pelengaris

series ordinal

2

1 reference

PMCID

3346985

11 August 2017

Michael Khan

series ordinal

3

1 reference

11 August 2017

22 April 2012

1 reference

International journal of endocrinology

11 August 2017

1 reference

11 August 2017

2012

1 reference

11 August 2017

516718

1 reference

Creative Commons Attribution 3.0 Unported

11 August 2017

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.

2 October 2017

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Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

2 October 2017

1 reference

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PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

2 October 2017

1 reference

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The functions of animal microRNAs

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Distinctive roles for prolactin and growth hormone in the activation of signal transducer and activator of transcription 5 in pancreatic islets of langerhans

2 October 2017

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Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets

2 October 2017

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2 October 2017

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2 October 2017

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Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells

2 October 2017

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MicroRNAs: genomics, biogenesis, mechanism, and function

2 October 2017

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Parathyroid hormone-related protein induces insulin expression through activation of MAP kinase-specific phosphatase-1 that dephosphorylates c-Jun NH2-terminal kinase in pancreatic beta-cells.

21 January 2018

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Transcriptional regulation by calcium, calcineurin, and NFAT

2 October 2017

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Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase.

2 October 2017

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Of mice and MEN1: Insulinomas in a conditional mouse knockout

2 October 2017

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2 October 2017

The many faces of c-MYC.

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Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids

2 October 2017

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Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway

2 October 2017

1 reference

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Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

2 October 2017

1 reference

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Glucotoxicity and beta-cell failure in type 2 diabetes mellitus

2 October 2017

1 reference

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Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor

2 October 2017

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

2 October 2017

1 reference

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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

2 October 2017

1 reference

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Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

2 October 2017

1 reference

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Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes

2 October 2017

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Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

2 October 2017

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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

2 October 2017

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Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

2 October 2017

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A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

2 October 2017

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Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells

2 October 2017

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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

2 October 2017

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Beta cell expression of IGF-I leads to recovery from type 1 diabetes.

2 October 2017

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Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation

2 October 2017

1 reference

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Insulin signalling and the regulation of glucose and lipid metabolism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

beta-Cell death during progression to diabetes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Oncogenic co-operation in beta-cell tumorigenesis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

The INK4a/ARF network in tumour suppression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

SOCS proteins: negative regulators of cytokine signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

High glucose stimulates early response gene c-Myc expression in rat pancreatic beta cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Evidence for a circulating islet cell growth factor in insulin-resistant states

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Regulation of beta-cell mass by hormones and growth factors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Islet growth and development in the adult

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Cell cycle control of pancreatic beta cell proliferation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Identification of CDK4 as a target of c-MYC.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Intracellular signalling: PDK1--a kinase at the hub of things

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Ras signalling and apoptosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Disruption of IRS-2 causes type 2 diabetes in mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Rat insulinoma-derived pancreatic beta-cells express a functional leptin receptor that mediates a proliferative response.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Signal transduction mechanism of insulin and insulin-like growth factor-1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

IGF-I: a mitogen also involved in differentiation processes in mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Raf meets Ras: completing the framework of a signal transduction pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Effects of transplantation and resection of a radiation-induced rat insulinoma on glucose homeostasis and the endocrine pancreas

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Role of prolactin versus growth hormone on islet B-cell proliferation in vitro: implications for pregnancy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Pancreatic beta-cell growth and diabetes mellitus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Mild chronic watery diarrhea-hypokalemia syndrome associated with pancreatic islet cell hyperplasia. Elevated plasma and tissue levels of gastric inhibitory polypeptide and successful management with nicotinic acid

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

A morphological study of the endocrine pancreas in human pregnancy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Leptin increases the viability of isolated rat pancreatic islets by suppressing apoptosis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Neogenesis vs. apoptosis As main components of pancreatic beta cell ass changes in glucose-infused normal and mildly diabetic adult rats

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the Belfast Diet Study.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Beta-cell mass depletion precedes the onset of hyperglycaemia in the GK rat, a genetic model of non-insulin-dependent diabetes mellitus.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Pancreatic beta-cell function and islet-cell proliferation: effect of hyperinsulinaemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Effect of genetic background on the capacity for islet cell replication in mice.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Growth hormone regulation of somatomedin C/insulin-like growth factor I production and DNA replication in fetal rat islets in tissue culture

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Type 2 diabetes-a matter of beta-cell life and death?

11 July 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Pancreatic duodenal homeobox-1 and islet neogenesis-associated protein: a possible combined marker of activateable pancreatic cell precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Specific and Combined Effects of Insulin and Glucose on Functional Pancreatic β-Cell Mass in Vivo in Adult Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Metabolic adaptations to chronic glucose infusion in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Control of pancreatic β cell regeneration by glucose metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Overstimulation and beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Gastric bypass and nesidioblastosis--too much of a good thing for islets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

GLP-1 C-terminal structures affect its blood glucose lowering-function

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]m

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Progressive pancreatic islet hyperplasia in the islet-targeted, parathyroid hormone-related protein-overexpressing mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Unacylated as well as acylated ghrelin promotes cell survival and inhibit apoptosis in HIT-T15 pancreatic beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Beta cell proliferation and growth factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Sex differences in newborn myocardial metabolism and response to ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

BMP4 regulates pancreatic progenitor cell expansion through Id2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Overexpression of cyclin D1 in pancreatic beta-cells in vivo results in islet hyperplasia without hypoglycemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Overexpression of FoxO1 causes proliferation of cultured pancreatic beta cells exposed to low nutrition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Regulation of pancreatic beta-cell mass and proliferation by SOCS-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

p57(KIP2) expression in normal islet cells and in hyperinsulinism of infancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

p27 Regulates the transition of beta-cells from quiescence to proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F516718

Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Improved beta-cell function after standardized weight reduction in severely obese subjects

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Number and size of islets of Langerhans in pregnant, human growth hormone-expressing transgenic, and pituitary dwarf mice: effect of lactogenic hormones

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346985

Compensatory Growth of Pancreatic -Cells in Adult Rats After Short-Term Glucose Infusion

24 September 2018

1 reference

12 December 2020

GLP-1/exendin-4 facilitates β-cell neogenesis in rat and human pancreatic ducts

1 reference

12 December 2020

Prolactin regulation of islet-derived INS-1 cells: characteristics and immunocytochemical analysis of STAT5 translocation

1 reference

12 December 2020

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans

1 reference

12 December 2020

Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery

1 reference

12 December 2020

Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes

1 reference

12 December 2020

Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus

1 reference

12 December 2020

Connexin implication in the control of the murine beta-cell mass

1 reference

12 December 2020

Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

1 reference

12 December 2020

Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement

1 reference

12 December 2020

Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release

1 reference

12 December 2020

Cx36 preferentially connects beta-cells within pancreatic islets

1 reference

12 December 2020

Parathyroid hormone-related peptide stimulates DNA synthesis and insulin secretion in pancreatic islets

1 reference

12 December 2020

The influence of hyperglycaemia, hyperinsulinaemia and genetic background on the fate of intrasplenically implanted mouse islets

1 reference

12 December 2020

Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy

1 reference

12 December 2020

Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas

1 reference

12 December 2020

Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models

1 reference

12 December 2020

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo

1 reference

12 December 2020

The role of glucose in the in vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic B-cells

1 reference

12 December 2020

Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl

1 reference

12 December 2020

Fetal pancreatic islets express functional leptin receptors and leptin stimulates proliferation of fetal islet cells

1 reference

12 December 2020

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

1 reference

12 December 2020

Growth hormone is a growth factor for the differentiated pancreatic beta-cell

1 reference

12 December 2020

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

1 reference

12 December 2020

Altered gap junctional communication, intercellular signaling, and growth in cultured astrocytes deficient in connexin43

1 reference

12 December 2020

Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass

1 reference

12 December 2020

Expression of dominant-negative STAT5 inhibits growth hormone- and prolactin-induced proliferation of insulin-producing cells

1 reference

12 December 2020

Leptin and adiponectin regulate compensatory beta cell growth in accordance to overweight

1 reference

12 December 2020

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

1 reference

12 December 2020

Stimulatory effect of insulin-like growth factor-I on [3H]thymidine incorporation, DNA content and insulin biosynthesis and secretion of isolated pancreatic rat islets

1 reference

12 December 2020

Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery

1 reference

12 December 2020

Interactions of nutrients, insulin-like growth factors (IGFs) and IGF-binding proteins in the regulation of DNA synthesis by isolated fetal rat islets of Langerhans

1 reference

12 December 2020

Evaluation of beta-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21cip

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/516718

1 reference

11 August 2017

1 reference

11 August 2017

1 reference

PMCID

3346985