Regulation of mTORC1 by PI3K signaling (Q26995791)

title

Regulation of mTORC1 by PI3K signaling (English)

0 references

author

Christian C. Dibble

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26159692%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Lewis C. Cantley

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26159692%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

author name string

Lewis C. Cantley

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

September 2015

1 reference

published in

Trends in Cell Biology

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26159692%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

volume

25

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26159692%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

page(s)

545-555

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26159692%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

issue

9

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26159692%20AND%20SRC:MED&resulttype=core&format=json

Rab1A is an mTORC1 activator and a colorectal oncogene

14 June 2020

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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

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21 March 2017

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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

21 March 2017

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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

21 March 2017

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Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes

21 March 2017

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 March 2017

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21 March 2017

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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

21 March 2017

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Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway

21 March 2017

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 March 2017

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mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

21 March 2017

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 March 2017

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The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

21 March 2017

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Functional dissection of Rab GTPases involved in primary cilium formation

21 March 2017

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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

21 March 2017

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 March 2017

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

21 March 2017

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Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B

21 March 2017

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 March 2017

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Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

21 March 2017

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PDK1, the master regulator of AGC kinase signal transduction

21 March 2017

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The GTPase-activating protein Rap1GAP uses a catalytic asparagine

21 March 2017

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 March 2017

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Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

21 March 2017

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 March 2017

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The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

21 March 2017

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Modulation of Akt kinase activity by binding to Hsp90

21 March 2017

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Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles

21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis

21 March 2017

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Molecular Basis of the Acceleration of the GDP-GTP Exchange of Human Ras Homolog Enriched in Brain by Human Translationally Controlled Tumor Protein

21 March 2017

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Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

21 March 2017

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21 March 2017

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 March 2017

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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

21 March 2017

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 March 2017

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 March 2017

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Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

21 March 2017

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Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin

21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

21 March 2017

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

21 March 2017

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21 March 2017

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21 March 2017

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 March 2017

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21 March 2017

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21 March 2017

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Rheb binds and regulates the mTOR kinase

21 March 2017

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The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

21 March 2017

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21 March 2017

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PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways

21 March 2017

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

21 March 2017

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Structural basis for the unique biological function of small GTPase RHEB

21 March 2017

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 March 2017

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Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

21 March 2017

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21 March 2017

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Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

21 March 2017

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Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice

21 March 2017

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The nuts and bolts of AGC protein kinases

21 March 2017

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Regulation of TORC1 by Rag GTPases in nutrient response

7 April 2017

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

7 April 2017

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Akt regulates growth by directly phosphorylating Tsc2

7 April 2017

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25 May 2017

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28 September 2017

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mTOR and autophagy: a dynamic relationship governed by nutrients and energy.

28 September 2017

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Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR)

28 September 2017

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Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).

28 September 2017

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Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

28 September 2017

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Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

28 September 2017

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Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts

28 September 2017

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A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.

28 September 2017

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A growing role for mTOR in promoting anabolic metabolism

28 September 2017

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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

28 September 2017

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The multifaceted role of mTORC1 in the control of lipid metabolism

28 September 2017

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Amino acid signalling upstream of mTOR

28 September 2017

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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

28 September 2017

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Rab proteins of the endoplasmic reticulum: functions and interactors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Target of rapamycin (TOR) in nutrient signaling and growth control

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

mTOR complex 2 signaling and functions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Rheb is essential for murine development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Rheb1 is required for mTORC1 and myelination in postnatal brain development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

mTOR phosphorylated at S2448 binds to raptor and rictor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

RalA functions as an indispensable signal mediator for the nutrient-sensing system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Phospholipase D1 is an effector of Rheb in the mTOR pathway.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

A role for Phospholipase D in Drosophila embryonic cellularization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Drosophila target of rapamycin kinase functions as a multimer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Regulation of the small GTPase Rheb by amino acids.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Tsc2 is not a critical target of Akt during normal Drosophila development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Drosophila Rheb GTPase is required for cell cycle progression and cell growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Rheb promotes cell growth as a component of the insulin/TOR signalling network

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

PI3K regulation of the SKP-2/p27 axis through mTORC2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc{gamma}-receptor-stimulated ROS production in neutrophils

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

The switch I region of Rheb is critical for its interaction with FKBP38.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Cell biology. Making sense of amino acid sensing.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

PI3K signalling: the path to discovery and understanding.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Tissue-specific coupling between insulin/IGF and TORC1 signaling via PRAS40 in Drosophila.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4734635

Redundant functions of phospholipases D1 and D2 in platelet α-granule release

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/26159692

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Post-prenylation-processing enzymes as new targets in oncogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26159692

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.TCB.2015.06.002

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26159692%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26159692%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

2 references